Present Status of Retroviral Mediated Gene Transfer into the Hematopoietic Tissue In Vivo: Possible Applications in Man

  • P. M. Lehn
Conference paper
Part of the Experimental Hematology Today—1989 book series (HEMATOLOGY, volume 1989)


Although the use of recombinant retroviruses for transferring specific genes (growth factors genes, oncogenes…) into hematopoietic cells has already noticeably contributed to our understanding of hematopoiesis, the aim of this review is to outline some current concepts relating to the use of retroviral vectors for gene therapy by bone marrow transplantation (BMT). Previous reviews have already described the basic features of the retroviral technology and reported the initial scientific data obtained. (1, 2, 3, 4). Therefore, the specific goal of this review is to summarize the most recent research data, to explain the remaining problems associated with the use of recombinant retroviruses for gene therapy and to indicate some possible future directions.


Globin Gene Packaging Cell Bone Marrow Transplantation Recipient Human Gene Therapy Somatic Gene Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag New York Inc. 1990

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  • P. M. Lehn

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