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Assessment of Posterior Segment Transport by Vitreous Fluorophotometry

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Noninvasive Diagnostic Techniques in Ophthalmology

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Abstract

The intraocular structures and fluids are separated from the blood by two barriers: the blood-aqueous barrier and the blood-retina barrier.1 The blood-aqueous barrier regulates the exchange between the blood and the aqueous humor and is dominated by an inward movement. The blood-retina barrier, responsible for the microenvironment of the retina, is divided into two components: an inner barrier and an outer barrier. The inner barrier is constituted by the cells in the walls of the retinal vessels that behave like a “nonleaky” epithelium. The outer barrier is located mainly in the retinal pigment epithelium, where the cells are united by junctional structures that firmly close the intercellular spaces, establishing an efficient barrier to diffusional movement and thus forcing transport through the highly selective transcellular route. There are indications that some of this transport is active.2

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  1. Ran C. Zeimer
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  1. Georgia Institute of Technology, Atlanta, Georgia, 30332-0250, USA

    Barry R. Masters Ph.D.

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Zeimer, R.C. (1990). Assessment of Posterior Segment Transport by Vitreous Fluorophotometry. In: Masters, B.R. (eds) Noninvasive Diagnostic Techniques in Ophthalmology. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8896-8_19

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  • DOI: https://doi.org/10.1007/978-1-4613-8896-8_19

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