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Genetic and Familial Aspects of Limb Defects with Emphasis on the Lower Extremities

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Congenital Lower Limb Deficiencies

Abstract

Limb malformations in human populations are common, with severe birth defects occurring in about 1 in every 200 (0.5%) newborn infants.1 Environmental agents such as teratogens are often invoked as a cause whenever a child presents with limb deficiencies or malformations. Although it is certainly true that it may be very difficult at times to determine whether or not a defect is hereditary, it is important to realize that genetic factors increasingly are being recognized in this group of conditions. As parents become more knowledgeable about genetics and environmental agents, they want to know the cause of their child’s problems and if there is risk of recurrence in subsequent pregnancies.

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Authors
  1. Charles I. Scott Jr.
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Editors and Affiliations

  1. Limestone Medical Center, Suite 209, 19808, Wilmington, DE, USA

    Ali Kalamchi M.D., F.A.C.S., F.R.C.S.

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© 1989 Springer-Verlag New York Inc.

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Scott, C.I. (1989). Genetic and Familial Aspects of Limb Defects with Emphasis on the Lower Extremities. In: Kalamchi, A. (eds) Congenital Lower Limb Deficiencies. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8882-1_2

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  • DOI: https://doi.org/10.1007/978-1-4613-8882-1_2

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-8884-5

  • Online ISBN: 978-1-4613-8882-1

  • eBook Packages: Springer Book Archive

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