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The Role of Hematopoietic Growth Factors in Nuclear and Radiation Accidents

  • Conference paper
Book cover Experimental Hematology Today—1988

Part of the book series: Experimental Hematology Today—1988 ((HEMATOLOGY,volume 1988))

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Abstract

Exposure to total body radiation results in dose dependent suppression of hematopoiesis (reviewed in 1–3). Variables influencing the extent of bone marrow suppression include total dose, dose rate, schedule, shielding, dose uniformity, as well as source-term parameters. Single-dose total body radiation at doses ≥ 1 Gy and dose rates ≥ 1 cGy per minute produce granulocytopenia and thrombocytopenia. Doses > 2 Gy can cause death from infection and bleeding. The 50% lethal dose (LD50) in humans is presumed to be 4–5 Gy based on data in animals. Higher radiation doses carry an increasing risk of death from bone marrow suppression; survival is unlikely after doses > 8–10 Gy. Doses > 15–20 Gy results in death from toxicity to other tissues such as the gastrointestinal tract or central nervous system.

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References

  1. UNSCEAR 1982. Ionizing radiation: sources and biologic effects. Report to the General Assembly, Vienna and New York.

    Google Scholar 

  2. Medical Research Council Committee on Effects of Ionizing Radiation. A forum on lethality from acute and protracted radiation exposure in man. Intl J Radiat Biol 1984; 46: 209–17.

    Article  Google Scholar 

  3. Mettler FA Jr, Moseley RD Jr: Medical Effects of Ionizing Radiation. New York Grune and Stratton. 1985.

    Google Scholar 

  4. Gale RP. Immediate medical consequences of nuclear accidents: Lessons from Chernobyl. JAMA 1987; 258: 625–8.

    Article  PubMed  CAS  Google Scholar 

  5. Gale RP. The role of bone marrow transplantation following nuclear accidents. Bone Marrow Transplantation 1987; 2: 1–6.

    PubMed  CAS  Google Scholar 

  6. Gale RP. The medical response to radiation and nuclear accidents: Lessons for the future. J Natl Cancer Inst Submitted

    Google Scholar 

  7. Gale RP, Reisner Y. Are bone marrow transplants effective after nuclear accidents? Lancet 1988; i:923–5.

    Article  Google Scholar 

  8. Abramson S, Miller RG, Phillips RA. The identification in adult bone marrow of pluripotent and restricted stem cells of the myeloid and lymphoid systems. J Exp Med 1977; 145: 1567–79.

    Article  PubMed  CAS  Google Scholar 

  9. Lemischka IR, Raulet DH, Mulligan RC. Developmental potential and dynamic behavior of hematopoietic stem cells. Cell 1986; 45: 917–27.

    Article  PubMed  CAS  Google Scholar 

  10. Roberts L. Radiation accident grips Goiania. Science. 1987; 238: 1028–31.

    Article  PubMed  CAS  Google Scholar 

  11. Golde DW, Takaku F (eds). Hematopoietic Stem Cells. New York, Marcel Dekker, Inc. 1985.

    Google Scholar 

  12. Wright DG, Greenberger JS (eds). Long-Term Bone Marrow Culture. New York, Alan R. Liss, Inc. 1984.

    Google Scholar 

  13. Metealf D. The molecular biology and functions of the granulocyte-marcophage colony-stimulating factors. Blood 1986; 67: 257–67.

    Google Scholar 

  14. Sieff CA. Hematopoietic growth factors. J Clin Invest 1987; 79: 1549–57.

    Article  PubMed  CAS  Google Scholar 

  15. Clark SC, Kamen R. The human hematopoietic colony stimulating factors. Science 1987; 236: 1229–37.

    Article  PubMed  CAS  Google Scholar 

  16. Donahue RE, Wange EA, Stone DK, et al. Stimulation of haematopoiesis in primates by continuous infusion of recombinant human GM-CSF. Nature 1986; 321: 872–5.

    Article  PubMed  CAS  Google Scholar 

  17. Welte K, Platzer E, Lu L, et al. Purification and biological characterization of human pluripotent hematopoietic colony stimulating factor. Proc Natl Acad Sci 1985; 82: 1526–30.

    Article  PubMed  CAS  Google Scholar 

  18. Donahue RE, Seehra J, Norton C, et al. Hematologic effects of recombinant human interleukin-3 (rhIL-3) and granulocyte/ macrophage colony-stimulating factor (rhGM-CSF) in primates. Proceedings of ASCO, Vol 7, March 1988, p 162.

    Google Scholar 

  19. Groopman JE, Mitsuyasu RT, DeLeo JM, Oette DH, Golde DW. Effect of recombinant human granulocyte-macrophage colony-stimulating factor on myelopoiesis in the acquired immunodeficiency syndrome. N Engl J Med 1987; 317: 593–8.

    Article  PubMed  CAS  Google Scholar 

  20. Brandt SJ, Peters WP, Atwater SK, et al. Effect of recombinant human granulocyte- macrophate colony-stimulating factor on hematopoietic reconstitution after high dose chemotherapy and autologous bone marrow transplantation. N Engl J Med 1988; 318: 870–6.

    Article  Google Scholar 

  21. Antman K, Griffin J, Elias A, et al. Use of rGM-CSF to ameliorate chemotherapy induced myelosuppression in sarcoma patients. Blood 1987; 70:Suppl 1: 129a.

    Google Scholar 

  22. Antin JH, Smith BR, Rosenthal DS, et al. Phase I/II study of recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) in bone marrow failure. Blood 1987; 70:Suppl 1: 129a.

    Google Scholar 

  23. Morstyn G, Souza LM, Keech J, et al. Effect of granulocyte colony stimulating factor on neutropenia induced by cytotoxic chemotherapy. Lancet 1988; i:667–71.

    Article  Google Scholar 

  24. Butturini AB, De Souza PC, Gale RP, et al. Use of recombinant GM-CSF in the Brazil radiation accident. Submitted

    Google Scholar 

  25. Blazar BR, Widmer MB, Soderling, et al. Augmentation of donor bone marrow engraftment in histoincompatible murine recipients by granulocyte-macrophage colony-stimulating factor. Blood 1988; 71: 320–8.

    PubMed  CAS  Google Scholar 

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Authors
  1. R. P. Gale
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  2. A. Butturini
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Editor information

Editors and Affiliations

  1. International Society for Experimental Hematology, Bethesda, Maryland, 20817, USA

    S. J. Baum (Treasurer) (Treasurer)

  2. Bone Marrow Transplantation Section, Department of Hematology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, 77030, USA

    K. A. Dicke

  3. Section of Natural Immunity, Department of General Surgery, University of Texas M.D. Anderson Cancer Center, Houston, Texas, 77030, USA

    E. Lotzová

  4. Laboratory of Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Marlyand, 20892, USA

    D. H. Pluznik

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© 1989 Springer Science+Business Media New York

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Gale, R.P., Butturini, A. (1989). The Role of Hematopoietic Growth Factors in Nuclear and Radiation Accidents. In: Baum, S.J., Dicke, K.A., Lotzová, E., Pluznik, D.H. (eds) Experimental Hematology Today—1988. Experimental Hematology Today—1988, vol 1988. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8862-3_27

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  • DOI: https://doi.org/10.1007/978-1-4613-8862-3_27

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-8864-7

  • Online ISBN: 978-1-4613-8862-3

  • eBook Packages: Springer Book Archive

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