The Role of Hematopoietic Growth Factors in Nuclear and Radiation Accidents

  • R. P. Gale
  • A. Butturini
Conference paper
Part of the Experimental Hematology Today—1988 book series (HEMATOLOGY, volume 1988)


Exposure to total body radiation results in dose dependent suppression of hematopoiesis (reviewed in 1–3). Variables influencing the extent of bone marrow suppression include total dose, dose rate, schedule, shielding, dose uniformity, as well as source-term parameters. Single-dose total body radiation at doses ≥ 1 Gy and dose rates ≥ 1 cGy per minute produce granulocytopenia and thrombocytopenia. Doses > 2 Gy can cause death from infection and bleeding. The 50% lethal dose (LD50) in humans is presumed to be 4–5 Gy based on data in animals. Higher radiation doses carry an increasing risk of death from bone marrow suppression; survival is unlikely after doses > 8–10 Gy. Doses > 15–20 Gy results in death from toxicity to other tissues such as the gastrointestinal tract or central nervous system.


Hematopoietic Stem Cell Total Body Radiation Bone Marrow Suppression Bone Marrow Failure Nuclear Accident 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • R. P. Gale
  • A. Butturini

There are no affiliations available

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