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Alterations in Dependence on Lipoxygenase Metabolism in Myeloid Leukemia

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Experimental Hematology Today—1988

Part of the book series: Experimental Hematology Today—1988 ((HEMATOLOGY,volume 1988))

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Abstract

Products of the lipoxygenase pathway of arachidonic acid metabolism are essential for the normal proliferation and differentiation of hematopoietic cells [1–4]. Leukotriene (LT) C4 and D4 have been demonstrated to be essential for the colony stimulating factor (CSF) induced growth of the granulocyte-monocyte progenitor cell (CFU-GM) in semi-solid culture. Since the initial report that an intact lipoxygenase pathway was necessary for normal CSF induced myeloid colony formation [1], several investigators have looked at the role of this pathway in the growth and differentiation of leukemic cells [5–10].

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References

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Authors
  1. A. M. Miller
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  2. K. Cullen
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  3. S. M. Kobb
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  4. R. S. Weiner
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Editor information

Editors and Affiliations

  1. International Society for Experimental Hematology, Bethesda, Maryland, 20817, USA

    S. J. Baum (Treasurer) (Treasurer)

  2. Bone Marrow Transplantation Section, Department of Hematology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, 77030, USA

    K. A. Dicke

  3. Section of Natural Immunity, Department of General Surgery, University of Texas M.D. Anderson Cancer Center, Houston, Texas, 77030, USA

    E. Lotzová

  4. Laboratory of Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Marlyand, 20892, USA

    D. H. Pluznik

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© 1989 Springer Science+Business Media New York

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Miller, A.M., Cullen, K., Kobb, S.M., Weiner, R.S. (1989). Alterations in Dependence on Lipoxygenase Metabolism in Myeloid Leukemia. In: Baum, S.J., Dicke, K.A., Lotzová, E., Pluznik, D.H. (eds) Experimental Hematology Today—1988. Experimental Hematology Today—1988, vol 1988. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8862-3_21

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  • DOI: https://doi.org/10.1007/978-1-4613-8862-3_21

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-8864-7

  • Online ISBN: 978-1-4613-8862-3

  • eBook Packages: Springer Book Archive

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