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The Regulation of Blast Stem Cell Self-Renewal in Myeloblastic Leukemia

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Experimental Hematology Today—1988

Part of the book series: Experimental Hematology Today—1988 ((HEMATOLOGY,volume 1988))

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Abstract

The blast cells of Acute Myeloblastic Leukemia are considered as a novel lineage, composed of segments of normal differentiation programs assembled abnormally, reflecting abnormal gene expression. AML blast cells can be grown in culture; the earliest blast progenitors have been shown to have the stem cell capacity of self-renewal. This paper considers certain aspects of self-renewal regulation. First, based on drug survival curves measured in two culture techniques, the suggestion is made that the balance between self-renewal and differentiation is regulated by specific genes. Second evidence is presented that blast proliferative patterns are affected by the growth factors IL-3, GM-CSF, G-CSF and CSF-1. The most consistent pattern is seen with CSF-1, where cells show decreased self-renewal when exposed to CSF-1 added to cultures or to the products of the CSF-1 gene as detected by Northern analysis. Finally, the importance of self-renewal is emphasized. It is proposed that drugs might be classified by their effect on this crucial cell function; further, that the chemosensitivity of self-renewal is an attribute contributing to clinical outcome.

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Authors
  1. E. A. McCulloch
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Editors and Affiliations

  1. International Society for Experimental Hematology, Bethesda, Maryland, 20817, USA

    S. J. Baum (Treasurer) (Treasurer)

  2. Bone Marrow Transplantation Section, Department of Hematology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, 77030, USA

    K. A. Dicke

  3. Section of Natural Immunity, Department of General Surgery, University of Texas M.D. Anderson Cancer Center, Houston, Texas, 77030, USA

    E. Lotzová

  4. Laboratory of Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, Marlyand, 20892, USA

    D. H. Pluznik

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McCulloch, E.A. (1989). The Regulation of Blast Stem Cell Self-Renewal in Myeloblastic Leukemia. In: Baum, S.J., Dicke, K.A., Lotzová, E., Pluznik, D.H. (eds) Experimental Hematology Today—1988. Experimental Hematology Today—1988, vol 1988. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8862-3_19

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  • DOI: https://doi.org/10.1007/978-1-4613-8862-3_19

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