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Cobalt in the Environment and Its Toxicological Implications

  • Jose L. Domingo
Part of the Reviews of Environmental Contamination and Toxicology book series (RECT, volume 108)

Abstract

Cobalt, atomic number 27, takes its name either from the German Kobold, meaning hobglobin, house spirit, or gnome or from the Greek cobalos, meaning mine (Schroeder 1967). It is widely distributed naturally in rocks, soils, water, and vegetation (Nilsson et al. 1985), and always occurs in nature in association with nickel and usually with arsenic. The most important cobalt minerals are smaltite (CoAs2) and cobaltite (CoAsS); however, the chief technical sources of cobalt are residues called “speisses,” which are obtained in the smelting of arsenical ores of nickel, copper, and lead (Cotton and Wilkinson 1968).

Keywords

Heme Oxygenase Cobalt Chloride Positive Patch Test Cobalt Compound Cobalt Sulfate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Adhikari S (1967) Effects of cobalt chloride on chick embryos. Anat Anz Bd 120(S):75–83.Google Scholar
  2. Ainsworth MA, Tompsett CP, Dean ACR (1980) Cobalt and nickel sensitivity and tolerance in Klebsiella pneumoniae. Microbios 27:175–184.PubMedGoogle Scholar
  3. Alexander CS (1969) Cobalt and the heart. Ann Int Med 70:411–413.PubMedGoogle Scholar
  4. Alexander CS (1972) Cobalt-beer cardiomyopathy. Am J Med 53:395–417.PubMedGoogle Scholar
  5. Al-Tawil NG, Marcusson JA, Möller E (1984) In vitro testing for cobalt sensitivity: An aid to diagnosis. Acta Derm Venereol (Stockh) 64:203–208.Google Scholar
  6. Andersen O (1983) Effects of coal combustion products and metal compounds on sister chromatid exchange (SCE) in a macrophagelike cell line. Environ Hlth Perspect 47:239–253.Google Scholar
  7. Andrews ED (1965) Cobalt poisoning in sheep. N Z Vet J 13:101–103.PubMedGoogle Scholar
  8. Barborik M, Dusek J (1972) Cardiomyopathy accompanying industrial cobalt exposure. Br Heart J 34:113–116.PubMedGoogle Scholar
  9. Bencko V, Wagner V, Wagnerová M, Zavázal V (1986) Human exposure to nickel and cobalt: Biological monitoring and immunobiochemical response. Environ Res 40:399–410.PubMedGoogle Scholar
  10. Berk L, Burchenal JH, Castle WB (1949) Erythropoietic effect of cobalt in patients with or without anemia. N Engl J Med 240:754–761.PubMedGoogle Scholar
  11. Brown DR, Southern LL (1985) Effect of “Eimeria Acervulina” infection in chicks fed excess dietary cobalt and/or manganese. J Nutr 115:347–351.PubMedGoogle Scholar
  12. Brown TE, Meineke HA (1958) Presence of an active erythropoietic factor (erytrhopoietin) in plasma of rats after prolonged cobalt therapy. Proc Soc Exp Biol Med 99:435–437.PubMedGoogle Scholar
  13. Bryan SE, Bright JE (1973) Serum protein responses elicited by iron, cobalt and mercury. Toxicol Appl Pharmacol 26:109–117.PubMedGoogle Scholar
  14. Burch RE, Williams RV, Sullivan JF (1973) Effect of cobalt, beer, and thiamin-deficient diets in pigs. Am J Clin Nutr 26:403–408.PubMedGoogle Scholar
  15. Calabrese EJ, Canada AT, Sacco C (1985) Trace elements and public health. Ann Rev Pub Hlth 6:131–146.Google Scholar
  16. Caplan RM, Block WD (1963) Experimental production of hyperlipemia in rabbits by cobaltous chloride. J Invest Dermatol 40:199–203.PubMedGoogle Scholar
  17. Carson BL, Smith IC (1979) Cobalt: An appraisal of environmental exposure. NIESH, Research Triangle Park, NC.Google Scholar
  18. Cartwright GE (1947) Dietary factors concerned in erythropoiesis. Blood 2:111–153.PubMedGoogle Scholar
  19. Catsch A, Harmuth-Hoene AE, Mellor DP (1979) The Chelation of Heavy Metals, 1st Ed. Pergamon Press, New York, pp 139–155.Google Scholar
  20. Coates EO, Watson JHL (1971) Diffuse interstitial lung disease in tungsten carbide workers. Ann Int Med 75:709–716.PubMedGoogle Scholar
  21. Coates EO, Sawjer HJ, Rebuck JN, Kvale PA, Sweret LW (1973) Hypersensitivity bronchitis in tungsten carbide workers. Chest 64:390.Google Scholar
  22. Correia MA, Schmid R (1975) Effect of cobalt on microsomal cytochrome P-450: Differences between liver and interstitial mucosa. Biochem Biophys Res Commun 65:1378–1387.PubMedGoogle Scholar
  23. Corrier DE, Mollenhauer HH, Clark DE, Hare MF, Elissalde MH (1985) Testicular degeneration and necrosis induced by dietary cobalt. Vet Pathol 22:610–616.PubMedGoogle Scholar
  24. Corrier DE, Rowe LD, Clark DE, Hare MF (1986) Tolerance and effect of chronic dietary cobalt on sheep. Vet Hum Toxicol 28:216–219.PubMedGoogle Scholar
  25. Cotton FA, Wilkinson G (1968) Advanced Inorganic Chemistry, 2nd Ed. John Wiley & Sons, New York, pp 863–878.Google Scholar
  26. Crosby WH (1955) The use of cobalt and cobalt-iron preparations in the therapy of anemia. Blood 10:852–861.Google Scholar
  27. Curtis JR, Goode GC, Herrington J, Urdaneta LE (1976) Possible cobalt toxicity in mainteneance hemodyalisis patients after treatment with cobaltous chloride: A study of blood and tissue cobalt concentrations in normal subjects and patients with terminal renal failure. Clin Nephrol 5:61–65.PubMedGoogle Scholar
  28. Davis JE (1940) The effect of ascorbic acid administration upon experimental polycythemias: The mechanism of cobalt polycythemia. Am J Physiol 129: 140–145.Google Scholar
  29. De Matteis F, Gibbs AH (1976) The effect of cobaltous chloride on liver haem metabolism in the rat. Evidence for inhibition of haem synthesis and for increased haem degradation. Ann Clin Res 8 (Suppl 17): 193–197.PubMedGoogle Scholar
  30. De Matteis F, Gibbs AH (1977) Inhibition of haem synthesis caused by cobalt in rat liver. Biochem J 162:213–216.PubMedGoogle Scholar
  31. Demedts M, Gheysens B, Nagels J, Verbeken E, Lauweryns J, Van den Eeckhout D, Lahager D, Gyelsen A (1984) Cobalt lung in diamond polishers. Am Rev Respir Dis 130:130–135.PubMedGoogle Scholar
  32. Dickson J, Bond MP (1974) Cobalt toxicity in cattle. Aust Vet J 50:236.PubMedGoogle Scholar
  33. Dingle JT, Heath JC, Webb M, Daniel M (1962) The biological action of cobalt and other metals. II. The mechanism of the respiratory inhibition produced by cobalt in mammalian tissues. Biochim Biophys Acta 65:34–46.PubMedGoogle Scholar
  34. Dixon JR, Lowe DB, Richards DE, Cralley LJ, Stokinger HE (1970) The role of trace metals in chemical carcinogenesis: Asbestos cancers. Cancer Res 30:1068–1074.PubMedGoogle Scholar
  35. Dooms-Goossens A, Ceuterick A, Vanmaele N, Degreef H (1980) Follow-up study of patients with contact dermatitis caused by chromates, nickel, and cobalt. Dermatologica 166:249–260.Google Scholar
  36. Domingo JL, Llobet JM, Corbella J (1983) The effects of EDTA in acute cobalt intoxication in rats. Toxicol Eur Res 6:251–255.Google Scholar
  37. Domingo JL, Llobet JM, Bernat R (1984a) Nutritional and toxicological study of cobalt administered to rats in their drinking water. Rev Toxicol 1:43–54.Google Scholar
  38. Domingo JL, Llobet JM, Bernat R (1984b) A study of the effects of cobalt administered orally to rats. Arch Farmacol Toxicol 10:13–20.PubMedGoogle Scholar
  39. Domingo JL, Llobet JM (1984c) Effectiveness of some chelating agents as antidotes for acute cobalt(II) intoxication. Rev Toxicol 1:147–155.Google Scholar
  40. Domingo JL, Llobet JM (1984d) Treatment of acute cobalt intoxication in rats with l-methionine. Rev Esp Fisiol 40:443–448.PubMedGoogle Scholar
  41. Domingo JL, Llobet JM (1984e) The action of l-cysteine in acute cobalt chloride intoxication. Rev Esp Fisiol 40:231–236.PubMedGoogle Scholar
  42. Domingo JL, Paternain JL, Llobet JM, Corbella J (1985a) Effects of cobalt on postnatal development and late gestation in rats upon oral administration. Rev Esp Fisiol 41:293–298.PubMedGoogle Scholar
  43. Domingo JL, Llobet JM, Tomás JM (1985b) N-Acetyl-l-cysteine in acute cobalt poisoning. Arch Farmacol Toxicol 11:55–62.PubMedGoogle Scholar
  44. Domingo JL, Llobet JM, Corbella J (1985c) The effect of l-histidine on acute cobalt intoxication in rats. Food Chem Toxicol 23:130–131.PubMedGoogle Scholar
  45. Drummond GS, Kappas A (1980) Metal ion interactions in the control of haem oxygenase induction in liver and kidney. Biochem J 192:637–648.PubMedGoogle Scholar
  46. Duckham JM, Lee HA (1976) The treatment of refractory anemia of chronic renal failure with cobalt chloride. Q J Med 178:277–294.Google Scholar
  47. Eaton DL, Stacey NH, Wong KL, Klaassen CD (1980) Dose-response effects of various metal ions on rat liver metallothionein, glutathione, heme oxygenase, and cytochrome P-450. Toxicol Appl Pharmacol 53:393–402.Google Scholar
  48. Elinder CG, Friberg L (1979) Cobalt. In: Friberg L, Nordberg F, Vouk VB (eds) Handbook on the Toxicology of Metals. Elsevier/North-Holland Biomedical Press, Amsterdam, pp 399–407.Google Scholar
  49. Elinder CG (1984) Health hazards from exposure to cobalt with special reference to carcinogenic, mutagenic and teratogenic effects. Toxicol Environ Chem 7: 251–256.Google Scholar
  50. Ellis NJ, Shallow M, Judson GJ (1987) Weight gain of lambs treated with a soluble glass bullet containing cobalt, selenium and copper. Aust Vet J 64:93–94.PubMedGoogle Scholar
  51. Factor SM, Sonnenblick EH (1985) The pathogenesis of clinical and experimental congestive cardiomyopathies: Recent concepts. Prog Cardiovasc Dis 27:395–420.PubMedGoogle Scholar
  52. Ferm HV (1972) The teratogenic effects of metals on mammalian embryos. Adv Teratol 6:51–75.Google Scholar
  53. Fischer J, Holubar J, Malik V (1967) A new method of producing chronic epileptogenic cortical foci in rats. Physiol Bohemoslov 16:272–277.PubMedGoogle Scholar
  54. Fodden JH (1953) Experiments with chemicals noxious to the pancreatic α-cells. Am J Clin Path 23:1002–1011.PubMedGoogle Scholar
  55. Frost DV, Elvehjem CA, Hart EB (1941) A study of the need for cobalt in dogs on milk diets. J Nutr 21:93–100.Google Scholar
  56. Gainer JH (1972) Increased mortality in encephalomyocarditis virus infected mice consuming cobalt sulfate: Tissue concentrations of cobalt. Am J Vet Res 33: 2067–2073.PubMedGoogle Scholar
  57. Gainer JH (1973) Activation of the Rauscher leukemia virus by metals. J Natl Cancer Inst 51:609–613.PubMedGoogle Scholar
  58. García-Toledo A, Babich H, Stotzky G (1985) Training of Rhizopus stolonifer and Cunninghamella blakesleeana to copper: Cotolerance to cadmium, cobalt, nickel, and lead. Can J Microbiol 31:485–492.Google Scholar
  59. Gerhardsson L, Wester PO, Nordberg GF, Brune D (1984) Chromium, cobalt and lanthanum in lung, liver and kidney tissue from decreased smelter workers. Sci Total Environ 37:233–246.PubMedGoogle Scholar
  60. Gheysens B, Auwerx J (1985) Cobalt-induced bronchial asthma in diamond polishers. Chest 88:740–744.PubMedGoogle Scholar
  61. Gilman JPW, Ruckerbauer GM (1962) Metal carcinogenesis. I. Observations on the carcinogenicity of a refinery dust, cobalt oxide, and colloidal thorium dioxide. Cancer Res 22:152–157.PubMedGoogle Scholar
  62. Giovannini E, Principato GB, Ambrosini V, Grassi G, Dell’Agata M (1978) Early effects of cobalt chloride treatment on certain blood parameters and on urine composition. J Pharmacol Expt Ther 206:398–404.Google Scholar
  63. Goldner MG, Volk BW, Lazarus SS (1952) The effects of cobaltous chloride on the blood sugar and α-cells in the pancreatic islets of rabbits. Metabolism 1:544–548.PubMedGoogle Scholar
  64. Gray P, Scully JM (1941) The suppressive effect of cobalt on the amnion in early chick development. Anat Rec 79:26–31.Google Scholar
  65. Gregus Z, Klaassen CD (1986) Disposition of metals in rats: A comparative study of fecal, urinary, and biliary excretion and tissue distribution of eighteen metals. Toxicol Appl Pharmacol 85:24–38.PubMedGoogle Scholar
  66. Grice HC, Goodman T, Munro IC, Wiberg GS, Morrison AB (1969) Myocardial toxicity of cobalt in the rat. Ann NY Acad Sci 158:189–194.Google Scholar
  67. Griffith WH, Pavcek PL, Mulford DJ (1942) The relation of the sulphur amino acids to the toxicity of cobalt and nickel in the rat. J Nutr 23:603–612.Google Scholar
  68. Gross RT, Spaet TA (1953) Cobaltous chloride in the treatment of sickle cell anemia. Stanford Med Bull 11:196–197.Google Scholar
  69. Hagiwara S, Byerly L (1981) Calcium channel. Ann Rev Neurosci 4:69–125.PubMedGoogle Scholar
  70. Hall JL, Smith GB (1968) Cobalt heart disease. An electron microscopic and histochemical study in the rabbit. Arch Pathol 86:403–412.Google Scholar
  71. Hamilton-Koch W, Snyder RD, Lavelle JM (1986) Mental-induced DNA damage and repair in human diploid fibroblasts and Chinese hamster ovary cells. Chem Biol Interact 59:17–28.PubMedGoogle Scholar
  72. Hartung M (1982) On the question of the pathogenic importance of cobalt for hard metal fibrosis of the lung. Int Arch Occup Environ Hlth 50:53–57.Google Scholar
  73. Hasegawa E, Smith C, Tephly TR (1970) Induction of hepatic mitochondrial ferrochelatase by phenobarbital. Biochem Biophys Res Commun 40:517–523.PubMedGoogle Scholar
  74. Heath JC (1954) The effect of cobalt on mitosis in tissue culture. Expt Cell Res 6:311–320.Google Scholar
  75. Heath JC (1956) The production of malignant tumours by cobalt in the rat. Br J Cancer 10:668–673.PubMedGoogle Scholar
  76. Heath JC (1960) The histogenesis of malignant tumours induced by cobalt in the rat. Br J Cancer 14:478–482.PubMedGoogle Scholar
  77. Heath JC, Webb M, Caffrey M (1969) The interaction of carcinogenic metals with tissues and body fluids. Cobalt and horse serum. Br J Cancer 23:153–166.PubMedGoogle Scholar
  78. Heath JC, Freeman MAR, Swanson SAV (1971) Carcinogenic properties of wear particles from prostheses made in cobalt-chromium alloy. Lancet 1:564–566.PubMedGoogle Scholar
  79. Hoey MJ (1966) The effects of metallic salts on the histology and functioning of the rat testis. J Reprod Fert 12:461–471.Google Scholar
  80. Hoffman DJ, Niyogi SK (1977) Metal mutagens and carcinogens affect RNA synthesis rates in a distinct mannor. Science 198:513–514.PubMedGoogle Scholar
  81. Holly RG (1955) Studies on iron and cobalt metabolism. JAMA 158:1349–1352.Google Scholar
  82. Ichikawa Y, Kusaka Y, Goto S (1985) Biological monitoring of cobalt exposure based on cobalt concentrations in blood and urine. Int Arch Occup Environ Hlth 55:269–276.Google Scholar
  83. Isom GE, Way JL (1974) Alteration in vivo glucose metabolism by cobaltous chloride. Toxicol Appl Pharmacol 27:131–139.PubMedGoogle Scholar
  84. Johansson A, Lundberg M, Hellström PA, Camner P, Keyser TR, Kirton SE, Natush DFS (1980) Effect of iron, cobalt, and chromium dust on rabbit alveolar macrophages: A comparison with the effects of nickel. Environ Res 21:165–176.PubMedGoogle Scholar
  85. Johansson A, Camner P, Jarstrand C, Wiernik A (1983) Rabbit alveolar macrophages after inhalation of soluble cadmium, cobalt, and copper. Environ Res 31:340–354.PubMedGoogle Scholar
  86. Johansson A, Cursted T, Robertson B, Camner P (1984) Lung morphology and phospholipids after experimental inhalation of soluble cadmium, copper and cobalt. Environ Res 34:295–309.PubMedGoogle Scholar
  87. Johansson A, Lundborg M, Wiernik A, Jarstrand C, Camner P (1986) Rabbit alveolar macrophages after long-term inhalation of soluble cobalt. Environ Res 41: 488–496.PubMedGoogle Scholar
  88. Johansson A, Robertson B, Camner P (1987) Nodular accumulation of type II cells and inflammatory lesions caused by inhalation of low cobalt concentrations. Environ Res 43:227–243.PubMedGoogle Scholar
  89. Kada T, Kanematsu N (1978) Reduction of N-methyl-N′-nitro-N-nitrosoguanidine-induced mutations by cobalt chloride in Escherichia coli. Proc Jap Acad Ser B 54:234–237.Google Scholar
  90. Kamboj VP, Amiya B (1964) Antitesticular effect of met and rare earth salts. J Reprod Fert 7:21–28.Google Scholar
  91. Kanematsu N, Hara M, Kada T (1980) Rec assay and mutagenicity studies on metal compounds. Mutat Res 77:109–116.PubMedGoogle Scholar
  92. Kaplowitz N (1981) The importance and regulation of hepatic glutathione. J Biol Med 54:497–502.Google Scholar
  93. Kaplowitz N, Eberle DE, Petrini J, Touloukian J, Cowasce C, Kuhlenkamp J (1983) Factors influencing the efflux of hepatic glutathione into bile in rats. J Pharmacol Expt Ther 224:141–147.Google Scholar
  94. Kasantzis G (1981) Role of cobalt, iron, lead, manganese, mercury, platinum, selenium, and titanium in carcinogenesis. Environ Hlth Perspect 40:143–161.Google Scholar
  95. Kennedy A, King R, Dornan JD (1981) Fatal myocardial disease associated with industrial exposure to cobalt. Lancet 1:412–414.PubMedGoogle Scholar
  96. Kerfoot EJ, Fredrick WG, Domeier E (1975) Cobalt metal inhalation on miniature swine. Am Ind Hyg Assoc J 36:17–25.PubMedGoogle Scholar
  97. Key MM (1961) Some unusual reactions in industry. Arch Dermatol 82:57–60.Google Scholar
  98. Kharab P, Singh I (1985) Genotoxic effects of potassium dichromate, sodium arsenite, cobalt chloride and lead nitrate in diploid yeast. Mutat Res 155:117–120.PubMedGoogle Scholar
  99. Kleinberg W (1934) Hemopoietic effect of cobalt and cobalt-manganese compounds in rabbits. Am J Physiol 108:545–549.Google Scholar
  100. Knott P, Algar B, Zervas G, Telfer SB (1985) Trace Elements in Man and Animals, TEMA 5, Mills CF, Bremner I, Chesters JK (eds), Cwlth Agric Bur, Slough, UK, p 708.Google Scholar
  101. Komezynski L, Nowak H, Rejniak L (1963) Effect of cobalt, nickel and iron on mitosis in roots of broad bean (Vicia faba). Nature 198:1016–1017.Google Scholar
  102. Kreyling WG, Ferron GA, Haider B (1986) Metabolic fate of inhaled cobalt aerosols in beagle dogs. Hlth Phys 51:773–795.Google Scholar
  103. Kusaka Y, Ichikawa Y, Shirakawa T, Goto S (1986) Effect of hard metal dust on ventilatory function. Br J Ind Med 43:486–489.PubMedGoogle Scholar
  104. Lammintausta K, Pitkänen OP, Kalimo K, Jansen CT (1985) Interrelationship of nickel and cobalt contact sensitization. Contact Dermatitis 13:148–152.PubMedGoogle Scholar
  105. Lee C, Malpeli JG (1986) Somata selective lesions induced by cobaltous chloride: A parametric study. Brain Res 364:396–399.PubMedGoogle Scholar
  106. Legrum W, Stuehmeier G, Netter KJ (1979) Cobalt as a modifier of microsomal monooxygenase in mice. Toxicol Appl Pharmacol 48:195–204.PubMedGoogle Scholar
  107. Lindergren CC, Nagai S, Nagai H (1958) Induction of respiratory deficiency in yeast by manganese, copper, cobalt and nickel. Nature 182:446–449.Google Scholar
  108. Llobet JM, Domingo JL (1983) Acute toxicity and hematologic and seric alterations from cobalt salts in rats. Rev Esp Fisiol 39:291–298.PubMedGoogle Scholar
  109. Llobet JM, Domingo JL, Corbella J (1985) Comparison of antidotal efficacy of chelating agents upon acute toxicity of cobalt (II) in mice. Res Commun Chem Pathol Pharmacol 50:305–308.PubMedGoogle Scholar
  110. Llobet JM, Domingo JL, Corbella J (1986) Comparison of the effectiveness of several chelators after single administration on the toxicity, excretion and distribution of cobalt. Arch Toxicol 58:278–281.PubMedGoogle Scholar
  111. Llobet JM, Domingo JL, Corbella J (1988) Comparative effects of repeated parenteral administration of several chelators on the distribution and excretion of cobalt. Res Commun Chem Pathol Pharmacol 60:225–233.PubMedGoogle Scholar
  112. Maines MD, Kappas A (1975) Cobalt stimulation of heme degradation in the liver. J Biol Chem 250:4171–4177.PubMedGoogle Scholar
  113. Maines MD, Kappas A (1976a) Studies on the mechanism of induction of haem oxygenase by cobalt and other metal ions. Biochem J 154:125–131.PubMedGoogle Scholar
  114. Maines MD, Janousek V, Tomio JM, Kappas A (1976b) Cobalt inhibition of synthesis and induction of (δ-aminolevulinate synthase in liver. Proc Natl Acad Sci (USA) 73:1499–1503.Google Scholar
  115. Maines MD, Kappas A (1977a) Regulation of heme pathway enzymes and cellular glutathione content by metals that do not chelate with tetrapyrroles: Blockade of metal effects by thiols. Proc Natl Acad Sci (USA) 74:1875–1878.Google Scholar
  116. Maines MD, Kappas A (1977b) Metals as regulators of heme metabolism. Science 198:1215–1221.PubMedGoogle Scholar
  117. Maines MD, Kappas A (1977c) Regulation of cytochrome P-450-dependent microsomal drug metabolism enzymes by nickel, cobalt and iron. Clin Pharmacol Ther 22:780–790.PubMedGoogle Scholar
  118. Malpeli JG, Burch BD (1982) Cobalt destroys neurons without destroying fibers of passage in the lateral geniculate nucleus of the cat. Neurosci Lett 32:29–34.PubMedGoogle Scholar
  119. Malpeli JG (1983) Activity of cells in area 17 of the cat in absence of input from layer A of lateral geniculate nucleus. J Neurophysiol 49:595–610.PubMedGoogle Scholar
  120. Mangiarotti G, Canavese C, Salomone M, Thea A, Pacitti A, Gaido M, Calitri V, Pelizza D, Canavero W, Vercellone A (1986) Hypervitaminosis B12 in mainteneance hemodialysis patients receiving massive supplementation of vitamin B12. Int J Artif Organs 9:417–420.PubMedGoogle Scholar
  121. Menné T (1980) Relationship between cobalt and nickel sensitization in hard metal workers. Contact Dermatitis 6:337–340.PubMedGoogle Scholar
  122. Miller CW, Davis MW, Goldman A, Wyatt JP (1953) Pneumoconiosis in the tungstencarbide tool industry. Arch Ind Hyg Occup Med 8:453–465.Google Scholar
  123. Mine T, Kimura S, Osawa H, Ogata E (1986) Inhibition of the glycogenolitic effects of α-adrenergic stimulation and glucagon by cobalt ions in perfused rat liver. Life Sci 38:2285–2292.PubMedGoogle Scholar
  124. Mitala JJ, Gautieri RF (1971) Apparent enzyme inhibition through enzyme-induction studies as a possible mode of action of certain cobalt compounds. J Pharm Sci 12:1878–1879.Google Scholar
  125. Mohiuddin SM, Taskar PK, Rheault M, Roy PE, Chenard J, Morin Y (1970) Experimental cobalt cardiomyopathy. Am Heart J 80:532–543.PubMedGoogle Scholar
  126. Mollenhauer HH, Corner DE, Clark DE, Hare MF, Elissalde MH (1985) Effects of dietary cobalt on testicular structure. Virchows Arch [Cell Pathol] 49:241–248.Google Scholar
  127. Morin Y, Daniel P (1967) Quebec beer-drinkers’ cardiomyopathy: Ethiological considerations. Can Med Assoc J 97:926–928.PubMedGoogle Scholar
  128. Morin Y, Tetu A, Mercier G (1971) Cobalt cardiomyopathy: clinical aspects. Br Heart J 33(Suppl): 175–178.PubMedGoogle Scholar
  129. Morgan LG (1983) A study into the health and mortality of men exposed to cobalt and oxides. J Soc Occup Med 33:181–186.PubMedGoogle Scholar
  130. Muñoz-Calvo R, Valcazar A, Lucas J (1973) Effect of cobalt chloride intoxication on seric lipids level and other parameters. Rev Esp Fisiol 29:61–64.PubMedGoogle Scholar
  131. Mur JM, Moulin JJ, Charruyer-Seinerra MP, Lafitte J (1987) A cohort mortality study among cobalt and sodium workers in an electrochemical plant. Am J Ind Med 11:75–81.PubMedGoogle Scholar
  132. Nakamura H (1962) Adaptation of yeast to cadmium. V. Characteristics of RNA and nitrogen metabolism in the resistance. Mem Konan Univ Sci Ser 6:19–31.Google Scholar
  133. Nation JR, Bourgeois AG, Clark DE, Hare MF (1983) The effects of chronic cobalt exposure on behavior and metalothionein levels in the adult rat. Neurobehav Toxicol Teratol 5:9–15.PubMedGoogle Scholar
  134. Nilsson K, Jensen BS, Carlsen L (1985) The migration chemistry of cobalt. Eur Appl Res 7:23–86.Google Scholar
  135. Nishioka H (1975) Mutagenic activities of metal compounds in bacteria. Mutat Res 31:185–189.PubMedGoogle Scholar
  136. Nofre C, Clément JM, Cier A (1963) Toxicité comparée de quelques ions métalliques et de leur chélate a l’acide éthylènediaminetétracétique. Path Biol 11:853–865.Google Scholar
  137. Ogawa HY, Tsuruta S, Niyitani Y, Mino H, Sakata K, Kato Y (1987) Mutagenicity of metals salts in combination with 9-amino-acridine in Salmonella typhimurium. Jap J Genet 62:159–162.Google Scholar
  138. Orten JM, Underhill FA, Mugrage ER, Lewis RC (1933) Blood volume studies in cobalt polycythemia. J Biol Chem 99:457–463.Google Scholar
  139. Orten JM (1936) On mechanism of hematopoietic action of cobalt. Am J Physiol 114:414–422.Google Scholar
  140. Orten JM, Bucciero MC (1948) The effect of cysteine, histidine, and methionine on the production of polycythemia by cobalt. J Biol Chem 176:961–968.PubMedGoogle Scholar
  141. Parry KE, Wood RKS (1958) The adaptation of fungi to fungicides: adaptation to copper and mercury salts. Ann Appl Biol 46:446–456.Google Scholar
  142. Paternain JL, Llobet JM, Domingo JL, Corbella J (1985) Effects of cobalt (II) on rat fertility, gestation, parturition, neonatal viability and growth rate. Rev Toxicol 2:93–103.Google Scholar
  143. Paternain JL, Domingo JL, Corbella J (1988) Developmental toxicity of cobalt in the rat. J Toxicol Environ Hlth 24:193–200.Google Scholar
  144. Paton GR, Allison AC (1972) Chromosome damage in human cell cultures induced by metal salts. Mutat Res 16:332–336.PubMedGoogle Scholar
  145. Payne LR (1977) The hazards of cobalt. J Soc Occup Med 27:20–25.PubMedGoogle Scholar
  146. Pitkänen A, Saano V, Hyvönen K, Airaksinen MM, Riekinnen PJ (1987) Decreased GABA, benzodiazepine, and picrotoxinin receptor binding in brains of rats after cobalt-induced epilepsy. Epilepsia 28:11–16.PubMedGoogle Scholar
  147. Popov LN (1977) An experimental study of the effects of low concentrations of metallic cobalt aerosols on the animal organism. Gig Sanit 4:97–98.PubMedGoogle Scholar
  148. Post JT (1955) Prevention of cobalt-induced polycythemia in rats by calcium ethylene diaminetetraacetic acid. Proc Soc Exp Biol Med 90:245–246.PubMedGoogle Scholar
  149. Prazmo W, Balbin E, Baranowska H, Ejchart A, Putrament A (1975) Manganese mutagenesis in yeast. II. Conditions of induction and characteristics of mitochondrial respiratory deficient Saccharomyces cerevisiae mutants induced with manganese and cobalt. Genet Res Camb 26:21–29.Google Scholar
  150. Putrament A, Baranowska H, Ejchart A, Jachymczyk N (1977) Manganese mutagenesis in yeast. VI. Mn2+ uptake, mitDNA replication and ER induction. Comparison with other divalent cations. Mol Gen Genet 151:69–76.PubMedGoogle Scholar
  151. Rhoads K, Sanders CL (1985) Lung clearance, translocation, and acute toxicity of arsenic, beryllium, cadmium, cobalt, lead, selenium, vanadium, and ytterbium oxides following deposition in rat lung. Environ Res 36:359–378.PubMedGoogle Scholar
  152. Ridgway LP, Karnofsky DA (1952) The effects of metals on the chick embryo: toxicity and production of abnormalities in development. Ann NY Acad Sci 55:203–215.PubMedGoogle Scholar
  153. Rona G (1971) Experimental aspects of cobalt cardiomyopathy. Br Heart J 33(Suppl): 171–174.PubMedGoogle Scholar
  154. Rona G, Chappel CI (1973) Pathogenesis and pathology of cobalt cardiomyopathy. In: Bajusz E, Rona G (eds) Recent Advances in Studies on Cardiac Structure and Metabolism. University Park Press, Baltimore, MD, pp 407–422.Google Scholar
  155. Ross OB, Philips PH, Bohstedt G, Cunha TJ (1944) Congenital malformations, syndactylism, talipes, and paralysis agitants of nutritional origin in swine. J Anim Sci 3:406–414.Google Scholar
  156. Roto P (1980) Asthma, symptoms of chronic bronchitis and ventilatory capacity among cobalt and zinc production workers. Scand J Work Environ Health Suppl 1:1–49.Google Scholar
  157. Rystedt I (1979) Evaluation and relevance of isolated test reactions to cobalt. Contact Dermatitis 5:233–238.PubMedGoogle Scholar
  158. Rystedt I, Fisher T (1983) Relationship between nickel and cobalt sensitization in hard metal workers. Contact Dermatitis 9:195–200.PubMedGoogle Scholar
  159. Sandusky GE, Henk WG, Roberts ED (1981) Histochemistry and ultrastructure of the heart in experimental cobalt cardiomyopathy in the dog. Toxicol Appl Pharmacol 61:89–98.PubMedGoogle Scholar
  160. Sardana MK, Drummond GS (1986) Tryptophan pyrrolase in heme metabolism. Comparative actions of inorganic tin and cobalt and their protoporphyrin chelates on tryptophan pyrrolase in liver. Biochem Pharmacol 35:473–478.PubMedGoogle Scholar
  161. Sardana MK, Kappas A (1987) Dual control mechanism for heme oxygenase: Tin(IV)-protoporphyrin potently inhibits enzyme activity while markedly increasing content of enzyme protein in liver. Proc Natl Acad Sci (USA) 84:2464–2468. Scansetti G, Lamon S, Talarico S, Botta GC, Spinelli P, Sulotto F, Fantoni F (1985)Google Scholar
  162. Urinary cobalt as a measure of exposure in the hard metal industry. Int Arch Occup Environ Hlth 57:19–26.Google Scholar
  163. Schade SG, Felsher BF, Glader BE, Conrad ME (1970) Effect of cobalt upon iron absorption. Proc Soc Exp Biol Med 34:741–743.Google Scholar
  164. Scharschmidt BG, Gollan JL (1979) Current concepts of bilirubin metabolism and hereditary hyperbilirubinemia. In: Popper H, Schaffner F (eds) Progress in Liver Diseases. Grune & Stratton, New York. pp 187–212.Google Scholar
  165. Schroeder HA, Nason AP, Tipton IH (1967) Essential trace metals in man: Cobalt. J Chron Dis 20:869–890.PubMedGoogle Scholar
  166. Schultz PN, Warren G, Kosso C, Rogers S (1982) Mutagenicity of a serie of hexacoordinate cobalt (III) compounds. Mutat Res 102:393–400.PubMedGoogle Scholar
  167. Schultze MO (1940) Metallic elements and blood formation. Physiol Rev 20:37–67.Google Scholar
  168. Shabaan AA, Marks V, Lancaster MC, Duffeu GN (1977) Fibrosarcomas induced by cobalt chloride in rats. Lab Anim 11:43–49.PubMedGoogle Scholar
  169. Singh NK, Chhabra R, Data K (1987) Nonenzymatic synthesis of δ-aminolevulinate (ALA) by cobalt (Co2+). Biochem Biophys Res Commun 143:439–446.PubMedGoogle Scholar
  170. Sirover MA, Loeb LA (1976) Infidelity of DNA synthesis in vitro: Screening for potential metal mutagens or carcinogens. Science 194:1434–1436.PubMedGoogle Scholar
  171. Sjögren I, Hillerdal G, Andersson A, Zetterström (1980) Hard metal lung disease: importance of cobalt in coolants. Thorax 35:653–659.PubMedGoogle Scholar
  172. Smith RJ, Contrera JF (1974) Cobalt-induced alterations in plasma proteins, proteases and kinin system of the rat. Biochem Pharmacol 23:1095–1103.PubMedGoogle Scholar
  173. Southern LL, Baker DH (1982) Eimeria acervulina infection in chichs fed cobalt in the presence or absence of excess dietary methionine. J Nutr 112:1220–1223.PubMedGoogle Scholar
  174. Southern LL, Baker DH (1983) Eimeria acervulina infection in chicks fed deficient or excess levels of manganese. J Nutr 113:172–177.PubMedGoogle Scholar
  175. Speijers GJA, Krajnc EI, Berkvens JM, Van Logten MJ (1982) Acute oral toxicity of inorganic cobalt compounds in rats. Food Chem Toxic 20:311–314.Google Scholar
  176. Stelzer KJ, Klaassen CD (1985) Effect of cobalt on biliary excretion of bilirubin and glutathione. J Toxicol Environ Hlth 15:813–822.Google Scholar
  177. Taylor A, Marks V (1978) Cobalt: A review. J Hum Nutr 32:165–177.PubMedGoogle Scholar
  178. Telib M, Schmidt FH (1973) Effects of cobaltous chloride in laboratory animals. II. Effect on blood sugar, plasma insulin and plasma lipids in rabbits. Endokrinologie 61:395–402.PubMedGoogle Scholar
  179. Tephly TR, Hibbeln P (1971) The effect of cobalt chloride administration on the synthesis of hepatic microsomal cytochrome P-450. Biochem Biophys Res Commun 42:589–595.PubMedGoogle Scholar
  180. Trengove CL, Judson GJ (1985) Trace element supplementation of sheep: evaluation of various copper supplements and a soluble glass bullet containing copper, cobalt and selenium. Aust Vet J 62:321–324.PubMedGoogle Scholar
  181. Tso WW, Fung WP (1981) Mutagenicity of metallic cations. Toxicol Lett 8:195–200.PubMedGoogle Scholar
  182. Underwood EJ (1975) Cobalt. Nutr Rev 33:65–69.PubMedGoogle Scholar
  183. Van Cutsem EJ, Ceuppens JL, Lacquet LM, Demedts M (1987) Combined asthma and alveolitis induced by cobalt in a diamond polisher. Eur J Respir Dis 70:54–61.PubMedGoogle Scholar
  184. Veien NK, Hattel T, Justesen O, Norholm A (1987) Oral challenge with nickel and cobalt in patients with positive patch tests to nickel and/or cobalt. Acta Derm Venereol (Stockh) 67:321–325.Google Scholar
  185. Vilaplana J, Grimait F, Romaguera C, Mascaró JM (1987) Cobalt content of household cleaning products. Contact Dermatitis 16:139–141.PubMedGoogle Scholar
  186. Webb M (1962) The biological action of cobalt and other metals. III. Chelation of cations by dihydrolipoic acid. Biochim Biophys Acta 65:47–65.PubMedGoogle Scholar
  187. Webb M (1964) The biological action of cobalt and other metals. IV. Inhibition of α-oxoglutarate dehydrogenase. Biochim Biophys Acta 89:431–446.PubMedGoogle Scholar
  188. Wehner AP, Busch RH, Olson RJ, Craig DK (1977) Chronic inhalation of cobalt oxide and cigarette smoke hamsters. Am Ind Hyg Assoc J 38:338–346.PubMedGoogle Scholar
  189. Weinzierl SM, Webb M (1972) Interaction of carcinogenic metals with tisue and body fluids. Br J Cancer 26:279–291.PubMedGoogle Scholar
  190. White IG (1955) The toxicity of heavy metals to mammalian spermatozoa. Aust J Exp Biol 33:359–366.Google Scholar
  191. Whitton BA, Shehata FHA (1982) Influence of cobalt, nickel, copper and cadmium on the blue-green alga Anacystis nidulans. Environ Pollut 27A:275–281.Google Scholar
  192. Wiberg GS, Munro IC, Méranger JC, Morrison AB, Grice HC (1969) Factors affecting the cardiotoxic potential of cobalt. Clin Toxicol 2:257–271.Google Scholar
  193. Zarafonetis CJ, Bartlett R, Brody GL (1965) Lipid mobilizer hormone in cobalt chloride hyperlipemia. JAMA 191:169–171.Google Scholar
  194. Yamagata N, Murata S, Torii T (1962) The cobalt content of the human body. J Rad Res (Tokyo) 3:4–8.Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1989

Authors and Affiliations

  • Jose L. Domingo
    • 1
  1. 1.Laboratory of Toxicology and Biochemistry, School of MedicineUniversity of BarcelonaReusSpain

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