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Neural Tube Defects: Prenatal Diagnosis and Genetic Counseling

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The Pediatric Spine I

Part of the book series: Principles of Pediatric Neurosurgery ((PRINCPEDIATR))

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Abstract

The practice of genetic counseling for neural tube defects (NTD) has changed substantially over the past 15 years with the advent of three major developments, i.e., second-trimester prenatal diagnosis, mass screening of pregnant women for elevated serum α-fetoprotein levels, and vitamin supplementation around the time of conception. On the other hand, the principles on which recurrence risk estimates are based have changed little, the multifactorial model of inheritance being the one that still fits best the epidemiologic data.

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Authors
  1. Giovanni Neri
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Editors and Affiliations

  1. Dipartimento di Neurochirurgia, Universita degli Studi, 37020, Gargagnago, Verona, Italy

    Anthony J. Raimondi M.D.

  2. Northwestern University Medical School, Chicago, Illinois, USA

    Anthony J. Raimondi M.D.

  3. Hôpital des Enfants de la Timone, Rue Saint Pierre, 13005, Marseille, France

    Maurice Choux M.D.

  4. Istituto di Neurochirurgia, Università Cattolica del Sacro Cuore, Largo Gemelli 8, 00168, Rome, Italy

    Concezio Di Rocco M.D.

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© 1989 Springer-Verlag New York Inc.

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Neri, G. (1989). Neural Tube Defects: Prenatal Diagnosis and Genetic Counseling. In: Raimondi, A.J., Choux, M., Di Rocco, C. (eds) The Pediatric Spine I. Principles of Pediatric Neurosurgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8820-3_7

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  • DOI: https://doi.org/10.1007/978-1-4613-8820-3_7

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-8822-7

  • Online ISBN: 978-1-4613-8820-3

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