Toxaphene (chlorinated camphene containing 67 to 69% chlorine) is also known as Alltex, Camphochlor, Chem-Phene, Compound 3956, Styobane T-90, and Kamfochlor. It is an insecticide used to combat caterpillars, grasshoppers, the cotton boll weevil, and ectoparasites on cattle and sheep (Meister 1987). Up until 1982, when all major uses of toxaphene were canceled by USEPA, it was widely used on soybeans, cotton, corn, wheat, and other crops. Current use levels of toxaphene are estimated to be very low. Its structure and properties are shown in Table 1.


Organochlorine Pesticide Health Advisory Chemical Abstract Service Governmental Industrial Hygienist Lifetime Excess Cancer Risk 
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  1. ACGIH. 1977. American Conference of Governmental Industrial Hygienists. TLVs: Threshold limit values for chemical substances and physical agents in the workroom environment with intended changes for 1977. ACGIH, Cincinnati, OH.Google Scholar
  2. Allen AL, Koller LD, Pollack GA (1983) Effect of toxaphene exposure on immune responses in mice. J Toxicol Environ Hlth 11: 61–69.CrossRefGoogle Scholar
  3. Boots Hercules Agrochemicals. 1973. Boots Hercules toxaphene insecticide summary of toxicological investigations. Bulletin T-105D. Boots Hercules Agrochemicals, Wilmington, DE. Submitted to the USEPA Office of Pesticide Programs, Washington, DC.Google Scholar
  4. Boyd EM, Taylor FI (1971) Toxaphene toxicity in protein-deficient rats. Toxicol Appl Pharmacol 18: 158–167.PubMedCrossRefGoogle Scholar
  5. Chandurkar PS, Matsumura F (1979) Metabolism of toxaphene components in rats. Arch Environ Contam Toxicol 8: 1–24.PubMedCrossRefGoogle Scholar
  6. Chernoff N, Carver BD (1976) Fetal toxicity of toxaphene in rats and mice. Bull Environ Contam Toxicol 15: 660–664.PubMedCrossRefGoogle Scholar
  7. Clapp KL, Nelson DM, Bell JT, et al. (1971) A study of the effects of toxaphene on the hepatic cells of rats. Proc Ann Meet Western Section, Am Soc Anim Sci 22: 313–323.Google Scholar
  8. Crowder LA, Dindal EF (1974) Fate of 36C1-toxaphene in rats. Bull Environ Contam Toxicol 12: 320–327.PubMedCrossRefGoogle Scholar
  9. Fitzhugh OG, Nelson AA (1951) Comparison of chronic effects produced in rats by several chlorinated hydrocarbon insecticides. Fed Proc 10: 295.Google Scholar
  10. Hayes WJ (1975) Toxicology of pesticides. Williams and Wilkins Co. Baltimore, MD.Google Scholar
  11. Hill RM (1977) Memorandum to Fred Hageman. December 15. USEPA Office of Toxic Substances, Washington, DC.Google Scholar
  12. Holmstead RL, Khalifa S, Casida JE (1974) Toxaphene composition analyzed by combined gas chromatography-chemical ionization mass spectrometry. J Agric Food Chem 22: 939–944.PubMedCrossRefGoogle Scholar
  13. IARC (1979) International Agency for Research on Cancer. Toxaphene (polychlorinated camphenes). IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, Vol 20. IARC, Lyon, France. pp 327–348.Google Scholar
  14. IUPAC (1979) International Union of Pure and Applied Chemistry. IUPAC reports on pesticides, Vol 7. Toxaphene (camphechlor). A special report. Pure Appl Chem 51: 1583–1601.CrossRefGoogle Scholar
  15. Lackey RW (1949) Observations on the acute and chronic toxicity of toxaphene in the dog. J Ind Hyg Toxicol 31: 117–120.PubMedGoogle Scholar
  16. Lehman AJ (1951) Chemicals in foods: A report to the Association of Food and Drug Officials on current developments. Part II. Pesticides. Q Bull Assoc Food Drug Offic US 15: 122–133.Google Scholar
  17. Lehman AJ (1952) Oral toxicity of toxaphene. Q Bull Assoc Food Drug Offic US 16: 47.Google Scholar
  18. Lehman AJ (1959) Appraisal of the safety of chemicals in foods, drugs, and cosmetics. Q Bull Assoc Food Drug Offic US. Association of Food and Drug Officials of the United States, Topeka, KS.Google Scholar
  19. Litton Bionetics, Inc (1978) Carcinogenic evaluation in mice. Toxaphene. Final report LBI Project no. 20602, Kensington, Maryland. Submitted to Hercules, Inc., Wilmington, DE.Google Scholar
  20. McGee LC, Reed HL, Fleming JP (1952) Accidental poisoning by toxaphene. J Am Med Assoc 149: 1124–1125.PubMedGoogle Scholar
  21. Meister RT, ed (1987) Farm chemicals handbook. Meister Publishing Company, Willoughby, OH.Google Scholar
  22. NCI (1979) National Cancer Institute. Bioassay of toxaphene for possible carcinogenesis. NCI Carcinogenesis Technical Report Series no. 37. Publication no. (NIH) 79–837. NCI, Bethesda, MD.Google Scholar
  23. NAS (1977) National Academy of Sciences. Drinking water and health, Vol 1. National Academy Press, Washington, DC.Google Scholar
  24. NTP (1983) National Toxicology Program. Annual plan for Fiscal Year 1983. Report no. NTP 82–119. NTP, Research Triangle Park, NC. p 66.Google Scholar
  25. Ohsawa T, Knox JR, Khalifa S, et al. (1975) Metabolic dechlorination of toxaphene in rats. J Agric Food Chem 23: 98–103.PubMedCrossRefGoogle Scholar
  26. Perry RH, Chilton CH (1973) Chemical engineers handbook. 5th Ed. McGraw-Hill Book Company, New York.Google Scholar
  27. Pollock GA and Hillstrand R (1982) The elimination, distribution and metabolism of 14C-toxaphene in the pregnant rat. J Environ Sci Hlth B17: 635–648.CrossRefGoogle Scholar
  28. Pollock GA, Kilgore WW (1978a) Toxaphene. Residue Reviews 69: 87–140.Google Scholar
  29. Pollock GA, Kilgore WW (1978b) The metabolism and excretion of toxaphene and selected toxaphene fractions. Toxicol Appl Pharmacol 45: 235.Google Scholar
  30. Saleh MA, Turner WV, Casida JE (1977) Polychlorobornane components of toxaphene: Structure-toxicity relations and metabolic reductive dechlorination. Science 198: 1256–1258.PubMedCrossRefGoogle Scholar
  31. Standard Methods (1985) Method 509A. Organochlorine pesticides. In: Standard methods for the examination of water and wastewater, 16th Ed. American Public Health Association, Washington, DC.Google Scholar
  32. USEPAa (1976) National interim primary drinking water regulations. Report no. EPA–570/9–76–003. USEPA Office of Drinking Water, Washington, DC.Google Scholar
  33. USEPAa (1978) Method for organochlorine pesticides in drinking water. Methods for organochlorine pesticides and chlorophenoxy acid herbicides in drinking water and raw source water. Interim. USEPA Office of Drinking Water, Washington, DC. July 1978.Google Scholar
  34. USEPA (1980) Water quality criteria documents: Availability. Fed Regis 45: 79340–79341.Google Scholar
  35. USEPAa (1983) Occurrence of pesticides in drinking water, food, and air. USEPA Office of Drinking Water, Washington, DC.Google Scholar
  36. USEPAa (1985a) Draft health effects criteria document for toxaphene. USEPA Office of Drinking Water, Washington, DC.Google Scholar
  37. USEPAa (1985b) Draft technologies and costs for the removal of synthetic organic chemicals from potable water supplies. USEPA Office of Drinking Water, Washington, DC.Google Scholar
  38. USEPA (1986) Guidelines for carcinogen risk assessment. Fed Regis 51(185): 33992–34003. September 24.Google Scholar
  39. USFDA (1984) U.S. Food and Drug Administration. Surveillance index for pesticides. USFDA Bureau of Foods, Washington, DC.Google Scholar
  40. Windholz M, Budavari S, Blumetti RF, Otterbein ES, eds. (1983) The Merck index—an encyclopedia of chemicals and drugs. 10th Ed. Merck & Co Inc, Rahway, NJ.Google Scholar
  41. Zweig G, Pye EL, Sitlani R, et al. (1963) Residues in milk from dairy cows fed low levels of toxaphene in their daily ration. J Agric Food Chem 11: 70–72.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1988

Authors and Affiliations

  • George W. Ware
    • 1
  1. 1.College of AgricultureUniversity of ArizonaTucsonUSA

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