The Control of Cardiac Output Through Coupling of Heart and Blood Vessels

  • Solbert Permutt
  • Robert A. Wise


At constant blood volume, the flow of blood from the blood vessels to the heart, the so-called venous return, is a function of the atrial pressures. The atrial pressures act as back pressures to flow from the blood vessels to the heart: The greater the atrial pressures, the less the flow. At the same time, the atrial pressures act in an opposite way on ejection of blood from the heart: The greater the atrial pressures, the greater the ventricular filling and stroke volume. The opposite effect of the atrial pressures on venous return and ventricular ejection is the focal point of the mechanical coupling of the heart and circuit as determinants of the steady-state cardiac output.


Cardiac Output Stressed Volume Venous Return Atrial Pressure Back Pressure 
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  1. Bellamy, R. F. 1978. Diastolic coronary artery pressure-flow relations in the dog. Circ. Res. 43:92–101.PubMedGoogle Scholar
  2. Brower, R., Wise, R. A., Hassapoyannes, C., Bromberger-Barnea, B., and Permutt, S. 1985. Effect of lung inflation on lung blood volume and pulmonary venous flow. J. Appl. Physiol. 58:954–963.PubMedCrossRefGoogle Scholar
  3. Brunner, M. J., Greene, A. S., Sagawa, K., and Shoukas, A. A. 1983. Determinants of systemic zero-flow arterial pressure. Am. J. Physiol. 245:H453–460.PubMedGoogle Scholar
  4. Brunner, M. J., Shoukas, A. A., and MacAnespie, C. C. 1981. The effect of the carotid baroreceptor reflex on blood flow and volume redistribution in the total systemic vascular bed of the dog. Circ. Res. 48:274–285.PubMedGoogle Scholar
  5. Caldini, P., Permutt, A., Waddell, J. A., and Riley, R. L. 1974. Effect of epinephrine on pressure, flow and volume relationships in the systemic circulation of dogs. Circ. Res. 34:606–623.PubMedGoogle Scholar
  6. Ehrlich, W. E., Baer, R. W., Bellamy, R. E., and Randazzo, R. 1980. Instantaneous femoral artery pressure flow relations in supine anesthetized dogs and the effect of unilateral elevation of femoral venous pressure. Circ. Res. 47:88–98.PubMedGoogle Scholar
  7. Guyton, A. C., Jones, C. E., and Coleman, T. G. 1973. Circulatory Physiology: Cardiac Output and its Regulation. 2nd Ed. Philadelphia: Saunders.Google Scholar
  8. Jachman, A. P., and Green, J. F. 1977. Arterial pressure-flow relationships in the anesthetized dog. Ann. Biomed. Eng. 54:384–394.CrossRefGoogle Scholar
  9. Permutt, S., Bromberger-Barnea, B., and Bane, H. N. 1962. Alveolar pressure, pulmonary venous pressure and the vascular waterfall. Med. Thorac. 19:239–260.PubMedGoogle Scholar
  10. Permutt, S., and Caldini, P. 1978. Regulation of cardiac output by the circuit: venous return. In Baan, J., Noordergraff, A., and Raines, J., eds. Cardiovascular System Dynamics. Cambridge, MA: MIT Press, pp. 465–479.Google Scholar
  11. Permutt, S., and Riley, R. L. 1963. Hemodynamics of collapsible vessels with tone: the vascular waterfall. J. Appl. Physiol. 18:924–932.PubMedGoogle Scholar
  12. Permutt, S., Wise, R., and Sylvester, J. T. 1985. Interaction between the ventilatory and circulatory pumps. In Roussos, C., and Macklem, P., eds. The Thorax. New York: Marcel Dekker, pp. 701–735.Google Scholar
  13. Sarnoff, S. J. 1955. Myocardial contractility as described by ventricular function curves: observations on Starling’s law of the heart. Physiol. Rev. 35:107–122.PubMedGoogle Scholar
  14. Slutsky, R. 1981. Response of the left ventricle to stress: effects of exercise, atrial pacing, afterload stress and drugs. Am. J. Cardiol. 47:357–364.PubMedCrossRefGoogle Scholar
  15. Suga, H., and Sagawa, K. 1974. Instantaneous pressure-volume relationships and their ratio in the exercised, supported canine left ventricle. Circ. Res. 35:117–126.PubMedGoogle Scholar
  16. Sylvester, J. T., Gilbert, R. D., Traystman, R. J., and Permutt, S. 1981. Effects of hypoxia on the closing pressure of the canine systemic arterial circulation. Circ. Res. 49:980.PubMedGoogle Scholar
  17. West, J. B., Dollery, C. T., and Naimark, A. 1964. Distribution of blood flow in isolated lung: relation to vascular and alveolar pressures. J. Appl. Physiol. 19:713–724.PubMedGoogle Scholar

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© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • Solbert Permutt
  • Robert A. Wise

There are no affiliations available

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