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Serum Levels of Digoxin and Endogenous Factor in the Newborn

  • Margarita Burgueros Valero
  • Dolores Rubio
  • Carmen Sanchez Jesus Perez
  • Fernando Benito
  • Felipe Moreno
Conference paper

Abstract

The aim of this study was to analyze the presence and possible interference of a digoxin-like, immunoreactive endogenous substance with measurement of digoxin levels in the newborn. We intended to assess the correlation between serum levels of digoxin therapy with acute (0.03 mg/kg) plus maintenance (0.01 mgr/kg/day) doses, therapy with maintenance doses only, and clinical and electrocardiographic (ECG) signs of digitalis toxicity. Serum levels of digoxin were analyzed with solid phase radioimmunoassay (RIA) (commercial kit of clinical assays) in 40 newborns with a gestational age from 28–42 weeks (mean, 38.5 weeks; SD, 3.8 weeks) and birth weight from 1,800–4,250 grams. Thirty-eight patients had a diagnosis of congenital heart disease and two had a cardiac rhythm disorder.

Keywords

Congenital Heart Disease Maintenance Dose Endogenous Factor Digoxin Level Clinical Assay 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Margarita Burgueros Valero
  • Dolores Rubio
  • Carmen Sanchez Jesus Perez
  • Fernando Benito
  • Felipe Moreno

There are no affiliations available

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