Rheumatic Fever: Interaction between Host, Microbe and Genetics

  • John B. Zabriskie
Conference paper


Among pathogenic organisms, the group A streptococcus continues to display a remarkable degree of versatility in its ability to evade the immune system of the host and to cause disease. Among the mechanisms employed by this organism are its ability to produce: 1) surface proteins that prevent phagocytosis, 2) mimicry of antigenic structures of the host, 3) immunosuppression of the host’s defenses, 4) secretion of products with specific affinity for organ structures, and 5) persistence of nonbiodegradable structures in host tissues. In many instances, the organism will employ more than one of these pathways to cause disease.


Host Tissue Rheumatic Fever Pathogenic Organism Streptococcal Infection Acute Rheumatic Fever 
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  1. 1.
    Zabriskie JB: Rheumatic fever: a streptococcal induced autoimmune disease? Pediatr Ann 11: 383–396, 1982.PubMedGoogle Scholar
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    Zabriskie JB: Rheumatic fever associated B cell allo-antigen as identified by monoclonal antibodies. Arthr Rheum (in press, 1985).Google Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • John B. Zabriskie

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