Pharmacologic Approaches to Pulmonary Hypertension in the Newborn
Almost every drug possessing vascular smooth muscle relaxant properties has been used to treat pulmonary hypertension, and many have been the subject of enthusiastic initial reports. Unfortunately, in every case, further experience has revealed a high rate of serious side effects and/or failure to respond. While no agent has been the subject of a properly conducted large-scale clinical trial, this is hardly surprising in view of the relative rarity of pulmonary hypertension and its considerable etiologic heterogeneity.
KeywordsPulmonary Hypertension Positive Inotropic Effect Hypoxic Pulmonary Vasoconstriction Pulmonary Vasodilator Systemic Hypotension
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