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Pharmacologic Approaches to Pulmonary Hypertension in the Newborn

  • Peter M. Olley
  • F. Coceani
Conference paper

Abstract

Almost every drug possessing vascular smooth muscle relaxant properties has been used to treat pulmonary hypertension, and many have been the subject of enthusiastic initial reports. Unfortunately, in every case, further experience has revealed a high rate of serious side effects and/or failure to respond. While no agent has been the subject of a properly conducted large-scale clinical trial, this is hardly surprising in view of the relative rarity of pulmonary hypertension and its considerable etiologic heterogeneity.

Keywords

Pulmonary Hypertension Positive Inotropic Effect Hypoxic Pulmonary Vasoconstriction Pulmonary Vasodilator Systemic Hypotension 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Aranda JV: Pharmacology of tolazoline in the newborn infant, in Persistent Fetal Circulation, edited by Sandor GGS, Macnab AJ, Rastogi RB, Mount Kisco, New York, Futura Media Services, 1984, pp 93–104.Google Scholar
  2. 2.
    Olley PM, Coceani F: The biochemistry and characteristics of the prostaglandins: possible therapeutic implications in persistent fetal circulation, in Persistent Fetal Circulation, edited by Sandor GGS, Macnab AJ, Rastogi RB, Mount Kisco, New York, Futura Media Services, 1984, pp 127–147.Google Scholar
  3. 3.
    Fishman AP: Hypoxia on the pulmonary circulation. How and where it acts. Circ Res 38: 221–231, 1976.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Peter M. Olley
  • F. Coceani

There are no affiliations available

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