Pharmacologic Approaches to Pulmonary Hypertension in the Newborn
Almost every drug possessing vascular smooth muscle relaxant properties has been used to treat pulmonary hypertension, and many have been the subject of enthusiastic initial reports. Unfortunately, in every case, further experience has revealed a high rate of serious side effects and/or failure to respond. While no agent has been the subject of a properly conducted large-scale clinical trial, this is hardly surprising in view of the relative rarity of pulmonary hypertension and its considerable etiologic heterogeneity.
KeywordsDopamine Serotonin Angiotensin Histamine Prostaglandin
Unable to display preview. Download preview PDF.
- 1.Aranda JV: Pharmacology of tolazoline in the newborn infant, in Persistent Fetal Circulation, edited by Sandor GGS, Macnab AJ, Rastogi RB, Mount Kisco, New York, Futura Media Services, 1984, pp 93–104.Google Scholar
- 2.Olley PM, Coceani F: The biochemistry and characteristics of the prostaglandins: possible therapeutic implications in persistent fetal circulation, in Persistent Fetal Circulation, edited by Sandor GGS, Macnab AJ, Rastogi RB, Mount Kisco, New York, Futura Media Services, 1984, pp 127–147.Google Scholar