Hormonal Influences in Cardiovascular Development

  • Abraham M. Rudolph
Conference paper


Hormones are important in the maturation of various enzyme systems involved in postnatal changes in carbohydrate and fat metabolism after birth. It has also been shown that cortisol and thyroid hormones influence production and release of pulmonary surface-active material. However, the role of hormones in the maturation of the circulation during the perinatal period has not been appreciated. Recently, two important areas in which hormones affect cardiovascular development have been defined.


Thyroid Hormone Patent Ductus Arteriosus Fetal Lamb Ventricular Output Cardiovascular Development 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Clyman RI: The role of the patent ductus arteriosus in respiratory distress syndrome. Sem Perinat 8: 293, 299, 1984.Google Scholar
  2. 2.
    Mcmurphy DM, Heymann MA, Rudolph AM, Melmon KL: Developmental changes in constriction of the ductus arteriosus; Responses to oxygen and vasoactive agents in the isolated ductus arteriosus of the fetal lamb. Pediatr Res 6: 231–238, 1972.PubMedCrossRefGoogle Scholar
  3. 3.
    Clyman RI, Mauray F, Roman C, Rudolph AM, Heymann MA: Glucocorticoids alter the sensitivity of the lamb ductus arteriosus to prostaglandin E2. J Pediatr 98: 126–128, 1981.PubMedCrossRefGoogle Scholar
  4. 4.
    Gilbert RD: Control of fetal cardiac output during changes in blood volume. Am J Physiol 238: H80 - H86, 1980.PubMedGoogle Scholar
  5. 5.
    Thornburg KL, Morton MJ: Filling and arterial pressures as determinants of RV stroke volume in the sheep fetus. Am J Physiol 244: H656 - H663, 1983.PubMedGoogle Scholar
  6. 6.
    Klopfenstein HS, Rudolph AM: Postnatal changes in the circulation and responses to volume loading in the sheep. Circ Res 42: 839–845, 1978.PubMedCrossRefGoogle Scholar
  7. 7.
    Fisher DA, Dussault JH, Sack J, Chopra IJ: Ontogenesis of hypothalamicpituitary-thyroid function and metabolism in man, sheep, and rat. Rec Prog Horm Res 3: 59–166, 1977.Google Scholar
  8. 8.
    Breall JA, Rudolph AM, Heymann MA: Role of thyroid hormone in postnatal circulatory and metabolic adjustments. J Clin Invest 73: 1418–1424, 1984.PubMedCrossRefGoogle Scholar
  9. 9.
    Everett AW, Clark WA, Chizzonite RA, Zak R: Change in synthesis rates of alpha-and beta-myosin heavy chains in rabbit heart after treatment with thyroid hormone. J Biol Chem 258: 2421, 1983.PubMedGoogle Scholar
  10. 10.
    Jackowski G, Kun E: The influence of triiodothyronine on polyadenosinediphosphoribose polymerase and RNA synthesis in cardiocyte nuclei. J Molec Cell Cardiol 14 (Suppl 3): 65, 1982.CrossRefGoogle Scholar
  11. 11.
    Whitsett JA, Pollinger J, Matz S: Beta-adrenergic receptors and catecholamine sensitive adenylate cyclase in developing rat ventricular myocardium: effect of thyroid status. Pediatr Res 16: 463–469, 1982.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Abraham M. Rudolph

There are no affiliations available

Personalised recommendations