Clinical Trials of Cardiac Xenotransplantation in Newborns with Hypoplastic Left Heart Syndrome

  • Leonard L. Bailey
Conference paper


Hypoplastic left heart syndrome (HLHS) is a complex, incorrectable congenital heart malformation that is usually lethal during the first month of life. It occurs in at least one newborn per day in the United States alone. Although Norwood et al. [1] have reported improved (50–60) early survival following the first procedure of a staged surgical approach for palliation of these patients, palliative efforts of most surgeons have failed.


Cardiac Transplantation Hypoplastic Left Heart Syndrome Mixed Lymphocyte Culture Heart Malformation Creatine Kinase Isoenzyme 
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  1. 1.
    Lang P, Norwood WI: Hemodynamic assessment after palliative surgery for hypoplastic left heart syndrome. Circulation 68: 104–108, 1983.PubMedCrossRefGoogle Scholar
  2. 2.
    Bailey LL, Nehlsen-Cannareila S, Concepcion W, Jolley WB: Baboonto-human cardiac xenotransplantation in a neonate. JAMA (submitted for publication).Google Scholar
  3. 3.
    Bailey LL, Lacour-Gayet F, Perier P, Killeen JD, Perry JE, Cotie RW, Schmidt CA, Denmark SH, Mahoney AD, Jolley WB: Orthotopic cardiac transplantation in the neonate. Survival studies in a goat model. Proceedings of Beijing Symposium on Cardiothoracic Surgery, ed 1. New York China Academic John Wiley & Sons, 1982, pp 342–350.Google Scholar
  4. 4.
    Bailey LL, Li ZH, Lacour-Gayet F, Perier P, Killeen JD, Perry JE, Schmidt CA, Roost H, Jolley WB: Orthotopic cardiac transplantation in the cyclosporine-treated neonate. Transplant Proc 15 (Suppl 1): 2956–2959, 1983.Google Scholar
  5. 5.
    Bailey LL, Li AJ, Roost H, Jolley WB: Host maturation after orthotopic cardiac transplantation during neonatal life. Heart Transplant 3: 265–267, 1984.Google Scholar
  6. 6.
    Bailey LL, Jang J, Johnson W, Jolley WB: Orthotopic cardiac xenografting in the newborn goat. J Thoracic Cardiovasc Surg 89: 242–247, 1985.Google Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Leonard L. Bailey

There are no affiliations available

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