Determinant Heterogeneity of CD5, CD8, and CD4 Antigen Molecules as Defined by Monoclonal Antibodies

  • Takashi Takei
  • Yoshifumi Ishii
  • Shinichiro Kon
  • Junichiro Fujimoto
  • Kokichi Kikuchi


A variety of human T cell surface antigens have been discovered through the use of monoclonal antibodies (mAbs) (1). Some of them have been postulated to play important roles in immunoregulation. T8 (Leu-2) and T4 (Leu-3) antigens, for example, which were originally thought to be suppressor/cytotoxic and helper/inducer T cell markers, respectively, have been analyzed in detail and the results indicate that T8 and T4 antigens serve as receptors for class I and class II major histocompatibility complex (MHC) antigens, respectively (2–4).


Major Histocompatibility Complex Human Thymocyte Leukocyte Typing Binding Inhibition Assay Cold Target Inhibition 
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© Springer-Verlag New York Inc. 1986

Authors and Affiliations

  • Takashi Takei
  • Yoshifumi Ishii
  • Shinichiro Kon
  • Junichiro Fujimoto
  • Kokichi Kikuchi

There are no affiliations available

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