Determinant Heterogeneity of CD5, CD8, and CD4 Antigen Molecules as Defined by Monoclonal Antibodies
A variety of human T cell surface antigens have been discovered through the use of monoclonal antibodies (mAbs) (1). Some of them have been postulated to play important roles in immunoregulation. T8 (Leu-2) and T4 (Leu-3) antigens, for example, which were originally thought to be suppressor/cytotoxic and helper/inducer T cell markers, respectively, have been analyzed in detail and the results indicate that T8 and T4 antigens serve as receptors for class I and class II major histocompatibility complex (MHC) antigens, respectively (2–4).
KeywordsMajor Histocompatibility Complex Human Thymocyte Leukocyte Typing Binding Inhibition Assay Cold Target Inhibition
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