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Mechanisms of HLA and Disease Associations

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HLA and Disease Associations

Abstract

The discoveries of HLA associations with certain diseases have been a major breakthrough in our understanding of the genetics of these diseases. We now know that at least part of the genetic basis of the associated diseases lies in the HLA region of chromosome 6. Furthermore, the “disease susceptibility genes” for hemochromatosis, congenital adrenal hyperplasia, and olivopontocerebellar ataxia (Menzel type) are known to be in linkage with HLA and have been mapped on chromosome 6.1 HLA markers are already providing some useful clinical information regarding these diseases (for references see the individual sections on these diseases). However, it is interesting to note that in the beginning these HLA associations generated high hopes and enthusiasm that the etiology of these diseases will soon be resolved. Yet, surprisingly, a decade after the landmark results on HLA-B27 and ankylosing spondylitis2,3 we are still searching for the mechanism(s) involved in these associations.

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Authors and Affiliations

  1. Center for The Health Sciences, UCLA Tissue Typing Laboratory, 1000 Veterans Avenue, Los Angeles, California, USA

    Jawahar L. Tiwari Ph.D.

  2. UCLA Hospital and Clinics, Los Angeles, California, USA

    Paul I. Terasaki Ph.D. (Professor of Surgery)

Authors
  1. Jawahar L. Tiwari Ph.D.
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  2. Paul I. Terasaki Ph.D.
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© 1985 Springer-Verlag New York, Inc.

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Tiwari, J.L., Terasaki, P.I. (1985). Mechanisms of HLA and Disease Associations. In: HLA and Disease Associations. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8545-5_4

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  • DOI: https://doi.org/10.1007/978-1-4613-8545-5_4

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-8547-9

  • Online ISBN: 978-1-4613-8545-5

  • eBook Packages: Springer Book Archive

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