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Immune Response

  • Jawahar L. Tiwari
  • Paul I. Terasaki

Abstract

Spencer et al.1 investigated the association of HLA antigens with antibody response in a clinical trial with live, attenuated, serum-inhibitor resistant, recombinant intranasal influenza A vaccine (“Alice” strain). This vaccine had the antigenic characteristics of A/England/42/72. In the first clinical trial 99 individuals were administered intranasal “Alice” strain vaccine. Fifty volunteers were given a placebo solution in 2 doses 14 days apart. A group of 50 other volunteers received a single intramuscular injection of a standard bivalent inactivated influenza vaccine.

Keywords

Celiac Disease Population Association High Responder Geometric Mean Titer Locus Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Spener MJ, Cherry JD, Terasaki PI: HL-A antigens and antibody response after influenza A vaccination. N Engl J Med 294:13–16, 1976CrossRefGoogle Scholar
  2. 2.
    Mackenzie JS, Wethrall JD, Flower RLP, Fimmel PJ, Dawkins RL: HL A antigens and the response to influenza A virus. Vox Sang 37:201–208, 1979PubMedCrossRefGoogle Scholar
  3. 3.
    Cunningham-Rundles S, Brown A, Gross D, Braun D, Hansen JA, Goor RA, et al: Association of HLA in immune response to influenza-A immunization. Transplant Proc 11:1849–1852, 1979PubMedGoogle Scholar
  4. 4.
    McMichael AJ, Ting A, Zweerink HJ, Askonas BA: HLA restriction of cell-mediated lysis of influenza virus-infected human cells. Nature 270:524–526, 1977PubMedCrossRefGoogle Scholar
  5. 5.
    Cuthbertson B, Dick HM, Sommerville RG: Histocompatibility types and antiviral antibodies in a diverse group of individuals. Hum Immunol 4:259–264, 1982PubMedCrossRefGoogle Scholar
  6. 6.
    Shaw S, Biddison WE: HLA-linked genetic control of the specificity of human cytotoxic T-cell responses to influenza virus. J Exp Med 149:565–575, 1979PubMedCrossRefGoogle Scholar
  7. 1.
    De Vries RRP, Kreeftenberg HG, Loggen HG, Van Rood JJ: In vitro immune responsiveness to vaccinia virus and HLA. N Engl J Med 297:692–696, 1977PubMedCrossRefGoogle Scholar
  8. 2.
    Cuthbertson B, Dick HM, Sommerville RG: Histocommpatibility types and antiviral antibodies in a diverse group of individuals. Hum Immunol 4:259–264, 1982PubMedCrossRefGoogle Scholar
  9. 1.
    Scott B, Cooke EM, Hambling MH, Rajah SM, Swinburne ML, Losowsky MS: HL-A8 and the immune response to various antigens. J Immunogenet 3:185–189, 1976PubMedCrossRefGoogle Scholar
  10. 2.
    Cuthbertson B, Dick HM, Sommerville RG: Histocompatibility types and antiviral antibodies in a diverse group of individuals. Hum Immunol 4:259–264, 1982PubMedCrossRefGoogle Scholar
  11. 1.
    Scott B, Cooke EM, Hambling MH, Rajah SM, Swinburne ML, Losowsky MS: HL-A8 and the immune response to various antigens. J Immunogenet 3:185–189, 1976PubMedCrossRefGoogle Scholar
  12. 2.
    Cuthbertson B, Dick HM, Sommerville RG: Histocompatibility types and antiviral antibodies in a diverse group of individuals. Hum Immunol 4:259–264, 1982PubMedCrossRefGoogle Scholar
  13. 1.
    Spencer MJ, Cherry JD, Powell KR, Mickey MR, Terasaki PI, Marcy SM, et al: Antibody responses following rubella immunization analyzed by HLA and ABO types. J Immunogenet 4:365–373, 1977CrossRefGoogle Scholar
  14. 2.
    Spencer MJ, Cherry JD, Terasaki PI, Powell KR, Sumaya CV, Marcy SM: Clinical and antibody response following immunization with RA27/3 rubella vaccine analyzed by HL-A type. Pediatr Res 10:393, 1976Google Scholar
  15. 3.
    Harcourt GC, Best JM, Banatvala JE, Kennedy LA: HLA antigens and responses to rubella vaccination. J Hyg 83:405–412, 1979CrossRefGoogle Scholar
  16. 4.
    Scott B, Cooke EM, Hambling MH, Rajah SM, Swinburne ML, Losowsky MS: HL-A8 and the immune response to various antigens. J Immunogenet 3:185–189, 1976PubMedCrossRefGoogle Scholar
  17. 5.
    Hansen HE, Larsen SO, Leerhoy J: Lack of correlation between the incidence of rubella antibody and the distribution of HLA antigens in a Danish population. Tissue Antigens 15:325–328, 1980PubMedCrossRefGoogle Scholar
  18. 6.
    Kato S, Kimura M, Takakura I, Sakakibara T, Inouye H, Tsuji K: Possible associations between HLA antigens and the immune responsiveness to attenuated rubella vaccine. Tissue Antigens 11:475–478, 1978PubMedCrossRefGoogle Scholar
  19. 7.
    Kato S, Muranaka S, Takakura I, Kimura M, Tsuji K. HLA-DR antigens and the rubella-specific immune response in man. Tissue Antigens 19:140–145, 1982PubMedCrossRefGoogle Scholar
  20. 8.
    Ishii K, Nakazono N, Sawada H, Wakisaka A, Moriuchi J, Nakai Y, et al: Antibody response following rubella immunization analyzed by HLA types. Jpn J Med Sei Biol 33:103–106, 1980Google Scholar
  21. 1.
    Cuthbertson B, Dick HM, Sommerville RG: Histocompatibility types and antiviral antibodies in a diverse group of individuals. Hum Immunol 4:259–264, 1982PubMedCrossRefGoogle Scholar
  22. 1.
    Cuthbertson B, Dick HM, Sommerville RG: Histocompatibility types and antiviral antibodies in a diverse group of individuals. Hum Immunol 4:259–264, 1982PubMedCrossRefGoogle Scholar
  23. 1.
    Sasazuki T, Kohno Y, Iwamoto I, Tanimura M, Naito S: Association between an HLA haplotype and low responsiveness to tetanus toxoid in man. Nature 272:359–361, 1978PubMedCrossRefGoogle Scholar
  24. 2.
    Repo H, Leirsalo M, Laitenen O: A contribution to immunopathogenesis of B27-associated diseases. Scand J Rheumatol 42:12, 1982CrossRefGoogle Scholar
  25. 1.
    Greenberg LJ, Gray ED, Yunis EJ: Association of HL-A5 and immune responsiveness in vitro to streptococcal antigens. J Exp Med 141:935–943, 1975PubMedCrossRefGoogle Scholar
  26. 2.
    Kawa A, Matsuyama T, Fujii H, Nakamura S, Ogaki S, Ooe H, et al.: Relations between the HLA-antigens and immune responsiveness to SK/SD in healthy Japanese subjects. Tissue Antigens 12:236–237, 1978PubMedCrossRefGoogle Scholar
  27. 3.
    Itoh C: Association of HLA with humoral immune responses. Tohoku J Exp Med 134:281–288, 1981PubMedCrossRefGoogle Scholar
  28. 4.
    Greenberg LJ, Chopyk RL, Bradley PW, Lalouel JM: Immunogenetics of response to a purified antigen from group A streptococci. Immunogenetics 11:161–167, 1980PubMedCrossRefGoogle Scholar
  29. 5.
    Greenberg LJ, Bradley PW, Chopyk RL, Lalouel JM: Genetic control of response to streptococcal antigens: Implication of two HLA-linked complementary loci. Transplant Proc 13:992–994, 1981PubMedGoogle Scholar
  30. 6.
    Sasazuki T, Kaneoka H, Nihimura Y, Kaneoka R, Hayama M, Ohkuni H: An HLA-linked immune suppression gene in man. J Exp Med 152:297s–313s, 1980PubMedGoogle Scholar
  31. 7.
    Nishimura Y, Sasazuki T: Suppressor T cells control the HLA-linked low responsiveness to streptococcal antigen in man. Nature 302:67–69, 1983PubMedCrossRefGoogle Scholar
  32. 8.
    Sasazuki T, Nishimura Y, Muto M, Ohta N: HLA-linked genes controlling immune response and disease susceptibility. Immunol Rev 70:51–75, 1983PubMedCrossRefGoogle Scholar
  33. 9.
    Nishimura Y: Genetic control of the immune response in man. Evidence for the HLA-linked immune suppression gene to streptococcal cell wall antigen. Fukuoka Igaku Zasshi 73:155–178, 1982PubMedGoogle Scholar
  34. 1.
    Buckley CE, White DH, Seigier HF: HLA-B7 associated tuberculin hyporesponsiveness in BCG treated melanoma patients. Monogr Allergy 11:97–105, 1977PubMedGoogle Scholar
  35. 1.
    Sasazuki T, Ohta N, Kaneoka R, Kojima S: Association between an HLA haplotype and low responsiveness to schistosomal worm antigens in man. J Exp Med 152:314s–318s, 1980PubMedGoogle Scholar
  36. 2.
    Sasazuki T, Nishimura Y, Muto M, Ohta N: HLA-linked genes controlling immune response and disease susceptibility. Immunol Rev 70:51–75, 1983PubMedCrossRefGoogle Scholar
  37. 1.
    Whittingham S, Mathews JD, Schanfield MS, Matthews JV, Tait BD, Morris PJ, et al: Interactive effect of GM allotypes and HLA-B locus antigens on the human antibody response to a bacterial antigen. Clin Exp Immunol 40:8–15, 1980PubMedGoogle Scholar
  38. 1.
    Nose Y, Komori K, Inouye H, Nomura K, Yamamura M, Tsuji K: Relationship between HLA-D and in vitro and in vivo responsiveness to Candida allergen. Clin Exp Immunol 40:345–350, 1980PubMedGoogle Scholar
  39. 2.
    Tsuji K, Nose Y, Inouye H, Komori K, Yamamura M: HLA-D/DR linked immune response to Candida allergen: An in vivo and in vitro study in Japanese. Tokai J Exp Clin Med 6:113–120, 1981PubMedGoogle Scholar
  40. 3.
    Nose Y, Komori K, Inouye H, Nomura K, Yamamura M, Tsuji K: Role of macrophages in T lymphocyte response to Candida allergen in man with special reference to HLA-D and DR. Clin Exp Immunol 45:152–157, 1981PubMedGoogle Scholar
  41. 1.
    Scott B, Cooke EM, Hambling MH, Rajah SM, Swinburne ML, Losowsky MS: HL-A8 and the immune response to various antigens. J Immunogenet 3:185–189, 1976PubMedCrossRefGoogle Scholar
  42. 2.
    Scott BB, Swinburne ML, Rajah SM, Losowsky MS: HL-A8 and the immune response to gluten. Lancet ii:374–377, 1974CrossRefGoogle Scholar
  43. 1.
    Scott BB, Swinburne ML, Rajah SM, Losowsky MS: HL-A8 and the immune response to gluten. Lancet ii:374–377, 1974CrossRefGoogle Scholar
  44. 2.
    Scott B, Cooke EM, Hambling MH, Rajah SM, Swinburne ML, Losowsky MS: HL-A8 and the immune response to various antigens. J Immunogenet 3:185–189, 1976PubMedCrossRefGoogle Scholar
  45. 3.
    Scott BB, Swinburne LM, Rajah SM, Losowsky MS: The HLA system and the immunological response to dietary antigens. Gut 15:823, 1974PubMedGoogle Scholar
  46. 4.
    Hobart MJ, Pétrie A: HL-A8 and the immune response to gluten. Lancet ii: 1573–1574, 1974CrossRefGoogle Scholar
  47. 5.
    Simpson FG, Bullen AW, Robertson DAF, Losowsky MS: HLA-B8 and cell-mediated immunity to gluten. Gut 22:633–636, 1981PubMedCrossRefGoogle Scholar
  48. 1.
    Scott B, Cooke EM, Hambling MH, Rajah SM, Swinburne ML, Losowsky MS: HL-A8 and the immune response to various antigens. J Immunogenet 3:185–189, 1976PubMedCrossRefGoogle Scholar
  49. 1.
    Brain P, Hammond MG: Association between histocompatibility type and the ability to make anti-Rh antibodies. Eur J Immunol 4:223–225, 1974PubMedCrossRefGoogle Scholar
  50. 2.
    Hors J, Dausset J, Gerbal A, Salmon C, Ropartz C, Lanset S: HL-A phenotype and anti-Rh(D) immunization. Haematologia 8:217–221, 1974PubMedGoogle Scholar
  51. 3.
    Reznikoff-Etievant MF, Muller JY, Julien F, Patereau C: An immune response gene linked to MHC in man. Tissue Antigens 22:312–314, 1983PubMedCrossRefGoogle Scholar
  52. 4.
    Darke C: HLA types and the immune response to the Rh(D) antigen. Tissue Antigens 9:171–172, 1977PubMedCrossRefGoogle Scholar
  53. 5.
    Darke C, Street J, Sargeant C, Dyer PA: HLA-DR antigens and properdin factor B allotypes in responded and nonresponders to the Rhesus-D antigen. Tissue Antigens 21:333–335, 1983PubMedCrossRefGoogle Scholar
  54. 6.
    Murray S, Dewar PJ, Lee E, McNay RA, Collins AK: A study of HL-A types in Rh haemolytic disease of the newborn. Vox Sang 30:91–104, 1976PubMedCrossRefGoogle Scholar
  55. 7.
    Turowski G, Morawska A, Turowska B: Alloimmunization to HL-A antigens and hemolytic disease of newborns on the background of incompatibility in the Rh system. Mater Med Pol 7:210–215, 1975PubMedGoogle Scholar
  56. 8.
    Moulinier J: Immunisation anti-HL-A et formes le-thales de maladie hemolytique Rh. Pathologica 64:39–41, 1972PubMedGoogle Scholar
  57. 9.
    Moulinier J, Merle MC: Histo-compatibilite et maladie rhesus. Bordeaux Med 3:919–924, 1970Google Scholar
  58. 1.
    Scher I, Berning AK, Strong DM, Green I: The immune response to a synthetic amino acid terpolymer in man: relationship to HL-A type. J Immunol 115:36–40, 1975PubMedGoogle Scholar
  59. 2.
    Hsu SH, Chan MM, Bias WB: Genetic control of major histocompatibility complex-linked immune responses to synthetic polypeptides in man. Proc Natl Acad Sei USA 78:440–444, 1981CrossRefGoogle Scholar
  60. 1.
    Spengler H, De Weck AL: Evaluation of genetic control of the immune response to penicillin in man. Monogr Allergy 11:116–123, 1977PubMedGoogle Scholar
  61. 1.
    Solinger AM, Stobo JD: Immune response gene control of collagen reactivity in man: Collagen unresponsiveness in HLA-DR4 negative nonresponders is due to the presence of T-dependent suppressive influences. J Immunol 129:1916–1920, 1982PubMedGoogle Scholar
  62. 1.
    Itoh C: Association of HLA with humoral immune responses. Tohoku J Exp Med 134:281–288, 1981PubMedCrossRefGoogle Scholar
  63. 1.
    Itoh C: Association of HLA with humoral immune responses. Tohoku J Exp Med 134:281–288, 1981PubMedCrossRefGoogle Scholar
  64. 1.
    Reznikoff-Etievant MF, Dangu C, Lobet R: HLA-B8 antigen and anti-PLA1 allo-immunization. Tissue Antigens 18:66–68, 1981PubMedCrossRefGoogle Scholar
  65. 2.
    Reznikoff-Etievant MF, Muller JY, Julien F, Patereau C: An immune response gene linked to MHC in man. Tissue Antigens 22:312–314, 1983PubMedCrossRefGoogle Scholar
  66. 1.
    Haverkorn MJ, Norrby E: Measles antibodies and HLA. J Immunogenet 5:129–134, 1978PubMedCrossRefGoogle Scholar
  67. 1.
    Griffing WL, Moore SB, Luthra HS, McKenna CH, Fathman CG: Associations of antibodies native to DNA with HLA-DRw3. A possible major histocompatibility complex-linked human immune response gene. J Exp Med 152:319s–325s, 1980PubMedGoogle Scholar
  68. 1.
    Wager O, Haltia K, Koskimies S, Tiilikainen A: HLA antigens and anti-albumin autoantibody response. Scand J Rheumatol 42:13, 1982CrossRefGoogle Scholar
  69. 1.
    Bryan CF, Nishiya K, Pollack MS, Dupont BO, Sousa MD: Differential inhibition of the MLR by iron: Association with HLA phenotype. Immunogenetics 12:129–140, 1981PubMedCrossRefGoogle Scholar
  70. 1.
    Ambinder JM, Chiorazzi N, Gibofsky A, Fotino M, Kunkel HG: Special characteristics of cellular immune function in normal individuals of the HLA-DR3 type. Clin Immunol Immunopathol 23:269–274, 1982PubMedCrossRefGoogle Scholar
  71. 1.
    Fraser PA, Schur PH: Hypoimmunoglobulinemia D: Frequency, family studies, and association with HLA. Clin Immunol Immunopathol 19:67–74, 1981PubMedCrossRefGoogle Scholar
  72. 1.
    Rodriguez MA, Bankhurst AD, Williams RC Jr, Troup GM, Stastny P: Studies on the relationship between HLA DR4 and in vitro IgM rheumatoid factor production. Clin Immunol Immunopathol 27:96–109, 1983PubMedCrossRefGoogle Scholar
  73. 1.
    Lawley TJ, Hall RP, Fauci AS, Katz SI, Hamburger MI, Frank MM: Defective Fc-receptor functions associated with the HLA-B8/DRw3 haplotype: Studies in patients with dermatitis herpetiformis and normal subjects. N Engl J Med 304:185–192, 1981PubMedCrossRefGoogle Scholar
  74. 2.
    Bartolotti SR: Defective Fc-receptor functions with the HLA-B8/DRw3 haplotype. N Engl J Med 305:346, 1981PubMedCrossRefGoogle Scholar
  75. 1.
    Legrand L, Perran-Rivat L, Huttin C, Dausset J: HLA-and Gm-linked genes affecting the degradation rate of antigens (sheep red blood cells) endocytized by macrophages. Hum Immunol 4:1–13, 1982PubMedCrossRefGoogle Scholar
  76. 1.
    McCombs CC, Michalski JP: Lymphocyte abnormality associated with HLA-B8 in healthy young adults. J Exp Med 156:936–941, 1982PubMedCrossRefGoogle Scholar
  77. 1.
    Andreotti PE, Cresswell P: HLA control of interferon production in the human mixed lymphocyte culture. Hum Immunol 3:109–120, 1981PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York, Inc. 1985

Authors and Affiliations

  • Jawahar L. Tiwari
    • 1
  • Paul I. Terasaki
    • 2
  1. 1.Center for The Health SciencesUCLA Tissue Typing LaboratoryLos AngelesUSA
  2. 2.UCLA Hospital and ClinicsLos AngelesUSA

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