The Swollen Optic Disc in Childhood

  • Michael C. Brodsky
  • Robert S. Baker
  • Latif M. Hamed

Abstract

“Optic disc elevation” is a reason for neuro-ophthalmologic referral common in children. The nature of the underlying disorder can often be predicted from the wording of the referring physician’s telephone call. Bilateral optic disc elevation without visual loss in a child with headaches, nausea, and vomiting of several months duration creates a high index of suspicion for papilledema (i.e., swelling of the optic discs secondary to elevated intracranial pressure). Blurring of the nasal disc margins which is noted as an incidental finding in an otherwise healthy child is usually found to be pseudopapilledema (i.e., real or apparent elevation of the optic discs due to local structural factors, which simulates swelling of the discs). Optic disc swelling in the setting of acute visual loss usually signifies optic neuritis.

Keywords

Leukemia Anemia Straw Cavitation Fluorescein 

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References

  1. 1.
    Aaberg TM. The expanding ophthalmologic spectrum of Lyme disease. Am J Ophthalmol 1989; 107:77–80.PubMedGoogle Scholar
  2. 2.
    Ahmad A, Pruett RC: The fundus in mongolism. Arch Ophthalmol 1976;94:772–776.PubMedGoogle Scholar
  3. 3.
    Ahmadieh H, Roodpeyma S, Azarmina M, et al. Bilateral simultaneous optic neuritis in childhood systemic lupus erythematosis: a case report. J Neuro-ophthalmol 1994;14:84–86.CrossRefGoogle Scholar
  4. 4.
    Ainsworth JR, Bryce IG, Dudgeon J. Visual loss in osteopetrosis. J Pediatr Ophthalmol Strabis 1993; 30:201–203.Google Scholar
  5. 5.
    Alagille D, Estrada A, Hadchouel M, et al. Syndromic paucity of interlobular bile ducts (Alagille syndrome or arteriohepatic dysplasia): review of 80 cases. J Pediatr 1987;110:195–200.PubMedCrossRefGoogle Scholar
  6. 6.
    Alexandrakis G, Filatov V, Walsh T. Pseudotumor cerebri in a 12-year-old boy with Addison’s disease. Am J Ophthalmol 1993;116:650–651.PubMedGoogle Scholar
  7. 6a.
    Al-Mefty O, Fox JL, Al-Rodhan N, Dew JH. Optic nerve decompression in osteopetrosis. J Neurosurg 1988;68:80–84.PubMedCrossRefGoogle Scholar
  8. 7.
    Al-Rodhan NRF, Sundt TM, Piepgras DG. Occlusive hyperemia: a theory for the hemodynamic complications following resection of intracerebral arteriovenous malformations. J Neurosurg 1993; 78:167–175.PubMedCrossRefGoogle Scholar
  9. 8.
    Allen RA, Straatsma BR. Ocular involvement in leukemia and allied disorders. Arch Ophthalmol 1961;66:68–86.Google Scholar
  10. 9.
    Alper MG. Management of primary optic nerve meningiomas. J Clin Neuro-ophthalmol 1981; 1:101–117.Google Scholar
  11. 10.
    Atlas SW, Grossman RI, Goldberg HI, et al. MR Diagnosis of acute disseminated encephalomyelitis. J Comput Asst Tomogr 1986;10:798–801.CrossRefGoogle Scholar
  12. 11.
    Avery R, Jabs DA, Wingard JR: Optic disc edema after bone marrow transplantation. Ophthalmology 1991;98:1294–1301.PubMedGoogle Scholar
  13. 12.
    Awan KJ. Hypotelorism and optic disc anomalies: an ignored ocular syndrome. Ann Ophthalmol 1977;9:771–777.PubMedGoogle Scholar
  14. 13.
    Babikian P, Corbett J, Bell W. Idiopathic intracranial hypertension in children: the Iowa experience. J Child Neurol 1994;9:144–149.PubMedCrossRefGoogle Scholar
  15. 14.
    Baker RS, Carter D, Hendrick EB, Buncic JR. Visual loss in pseudotumor cerebri: a follow-up study. Arch Ophthalmol 1985;103:1681–1686.PubMedGoogle Scholar
  16. 15.
    Baker RS, Baumann RJ, Buncic JR Idiopathic intracranial hypertension (pseudotumor cerebri) in pediatric patients. Pediatr Neurol 1989;5:5–11.PubMedCrossRefGoogle Scholar
  17. 16.
    Bar S, Segal M, Shapira R, Savir H. Neuroretinitis associated with cat scratch disease. Am J Ophthalmol 1990;110:703–705.PubMedGoogle Scholar
  18. 17.
    Barr CC, Glaser JS, Blankenship G. Acute disc swelling in juvenile diabetes. Arch Ophthalmol 1980;98:2185–2192.PubMedGoogle Scholar
  19. 18.
    Baum PA, Barkovich AJ, Coch TK, Berg BO. Deep gray matter involvement in children with acute disseminated encephalomyelitis. AJNR 1994;15:1275–1283.PubMedGoogle Scholar
  20. 19.
    Beardsley TL, Brown S, Sydnor CF, et al. Eleven cases of sarcoidosis of the optic nerve. Am J Ophthalmol 1984;97:62–77.PubMedGoogle Scholar
  21. 20.
    Bec P, Adam P, Mathis A, et al. Optic nerve head drusen: high resolution computed tomographic approach. Arch Ophthalmol 1984;102:680–682.PubMedGoogle Scholar
  22. 21.
    Beck M. Papilledema in association with Hunter’s syndrome. Br J Ophthalmol 1983;67:174–177.PubMedCrossRefGoogle Scholar
  23. 22.
    Beck M, Cole G. Disc oedema in association with Hunter’s syndrome: ocular histopathological findings. Br J Ophthalmol 1984;68:590–594.PubMedCrossRefGoogle Scholar
  24. 23.
    Beck RW, Corbett JJ, Thompson HS, Sergott RC. Decreased visual acuity from optic disc drusen. Arch Ophthalmol 1985;103:1155–1159.PubMedGoogle Scholar
  25. 24.
    Beck RW, Arrington J, Murtagh FR, et al. Brain MRI in acute optic neuritis: experience of the optic Neuritis Study Group. Arch Neurol 1993;8: 841846.Google Scholar
  26. 25.
    Beck RW, Cleary PA, Trobe JD, et al. The effect of corticosteroids for acute optic neuritis on the subsequent development of multiple sclerosis. N Engl J Med 1993;329:1764–1769.PubMedCrossRefGoogle Scholar
  27. 26.
    Beck AD, Newman NJ, Grossniklaus HE, et al. Optic nerve enlargement and chronic visual loss. Surv Ophthalmol 1994;38:555-566.Google Scholar
  28. 27.
    Benson WE. Posterior scleritis. Surv Ophthalmol 1988;32:297-316.Google Scholar
  29. 28.
    Berrios RR, Serrano LA. Bilateral optic neuritis after a bee sting. Am J Ophthalmol 1994;117:677.Google Scholar
  30. 29.
    Bertelsen TI. The premature synostosis of the cranial sutures. Acta Ophthalmol (Copenh) 1980;58 (suppl):733.Google Scholar
  31. 30.
    Bird AC, Smith JL, Curtin VT. Nematode optic neuritis. Am J Ophthalmol 1970;69:72-77.Google Scholar
  32. 31.
    Blaustein A, Caccavo A. Infectious mononucleosis complicated by bilateral papilloretinal edema. Arch Ophtahlmol 1950;43:853-856.Google Scholar
  33. 32.
    Boldt HC, Byrne SF, DiBernardo C. Echographic evaluation of optic disc drusen. J Clin Neuroophthalmol 1991;11(2):85-91.Google Scholar
  34. 33.
    Boyce SW, Platia EV, Green WR. Drusen of the optic nerve head. Ann Ophthalmol 1978;10:695704.Google Scholar
  35. 34.
    Boynton JR, Pheasant TR, Johnson BL, et al. Ocular findings in Kenny’s syndrome. Arch Ophthalmol 1979;97:896-900.Google Scholar
  36. 35.
    Brazis PW, Stokes MR, Ervin FR. Optic neuritis in cat scratch disease. J Clin Neuro-ophthalmol 1986;6:172-174.Google Scholar
  37. 36.
    Brodsky MC, Cunniff C. Ocular anomalies in the Alagille syndrome. Ophthalmology 1993;100: 1767-1774.Google Scholar
  38. 37.
    Brodsky MC, Beck RW. The changing role of MR imaging in the evaluation of acute optic neuritis. Editorial. Radiology 1994;192:22-23.Google Scholar
  39. 38.
    Brodsky MC, Glasier CM. Intraocular enhancement of the swollen optic disc on MR imaging. J Clin Neuro-ophthalmol,1995. In press.Google Scholar
  40. 39.
    Brodsky MC, Wald KJ, Chen S, Weiter JJ. Protracted posttraumatic optic disc swelling. Ophthalmology 1995. In press.Google Scholar
  41. 40.
    Budenz DL, Farber MG, Mirchandani HG, et al. Ocular and optic nerve hemorrhages in abused infants with intracranial injuries. Ophthalmology 1994;101:559-565.Google Scholar
  42. 41.
    Burde RM. Optic disk risk factors for nonarteritic anterior ischemic optic neuropathy. Am J Ophthalmo11993;116:759-764.Google Scholar
  43. 42.
    Bye A, Dendall B, Wilson J. Multiple sclerosis in childhood: a new look. Dev Med Child Neurol 1985;27:215-222.Google Scholar
  44. 43.
    Byrd SE, Locke GE, Biggers S, Percy AK. The computed tomographic appearance of cerebral cysticercosis in adults and children. Radiology 1982; 144:819-823.Google Scholar
  45. 44.
    Caffey J. On the theory and practice of shaking infants: its potential residual effects of permanent brain damage and mental retardation. Am J Dis Child 1972;124:161-169.Google Scholar
  46. 45.
    Campbell SH, Patterson A. Pseudopapilloedema in the linear naevus syndrome. Br J Ophthalmol 1992;76:372-374.Google Scholar
  47. 46.
    Catalano RA, Simon JW. Optic disc elevation in Down syndrome. Am J Ophthalmol 1990; 110:2832.Google Scholar
  48. 47.
    Chrousos GA, Drack AV, Young M, et al. Neuroretinitis in cat scratch disease. J Clin Neuro-ophthalmol 1990;10:92-94.Google Scholar
  49. 48.
    Coleman K, Hope Ross M, McCabe M, et al. Disk drusen and angioid streaks in pseudoxanthoma elasticum. Am J Ophthalmol 1991;112:166-170.Google Scholar
  50. 49.
    Collins MLZ, Traboulsi EI, Maumenee IH. Optic nerve head swelling and optic atrophy in the systemic mucopolysaccharidoses. Ophthalmology 1990;97:1445-1449.Google Scholar
  51. 50.
    Connally MB, Farrell K, Hill A, Flodmark 0. Magnetic resonance imaging in pseudotumor cerebri. Dev Med Child Neurol 1992;34:1091-1094.Google Scholar
  52. 51.
    Corbett J. neuro-ophthalmologic complications of hydrocephalus and shunting procedures. Semin Neuro11986;6(2):111-123.Google Scholar
  53. 52.
    Corbett A Jacobson DM, Mauer RC, Thompson HS. Enlargment of the blind spot caused by papilledema. Am J Ophthalmol 1988;105:261-265.Google Scholar
  54. 53.
    Corbett JJ, Thompson HS. The rational management of idiopathic intracranial hypertension. Arch Neurol 1989;46:1049-1051.Google Scholar
  55. 54.
    Corbett JJ. Mechanisms of elevated intracranial pressure in idiopathic intracranial hypertension. Presented at the North American Neuro-Ophthal mology Society Meeting, Rancho Bernardo, CA, February 1992.Google Scholar
  56. 55.
    Couch R, Camfield PR, Tibbles JAR. The changing picture of pseudotumor cerebri in children. Can J Neurol Sci 1985;12:48-50.Google Scholar
  57. 56.
    Cox TA, Haskins GE, Gangitano JL, Antonson DL. Bilateral toxocara optic neuropathy. J Clin Neuroophthalmol 1983;3:267-274.Google Scholar
  58. 57.
    Currie JN, Lessell S, Lessell IM, et al. Optic neuropathy in chronic lymphocytic leukemia. Arch Ophthalmol 1988;106:654-660.Google Scholar
  59. 58.
    Davis LE, Kornfeld M. Neurocysticercosis: Neurologic, pathogenic, diagnostic, and therapeutic aspects. Eur Neurol 1991;31:229-240.Google Scholar
  60. 59.
    De Bustros S, Miller NR, Finkelstein D, et al. Bilateral astrocytic hamartomas of the optic nerveheads in retinitis pigmentosa. Retina 1983;3: 2123.Google Scholar
  61. 60.
    Donaldson JO. Pathogenesis of pseudotumor cerebri syndromes. Neurology 1981;31:877-880.Google Scholar
  62. 61.
    Dossetor FM, Landau K, Hoyt WF. Optic disk glioma in Neurofibromatosis Type 2. Am J Ophthalmol 1989;108:602-603.Google Scholar
  63. 62.
    Dreyer RF, Hopen G, Gass DM, Smith JL. Leber’s stellate idiopathic neuroretinitis. Arch Ophthalmol 1984;102:1140-1145.Google Scholar
  64. 63.
    Dufier JL, Vinurel MC, Renier D, Marchac D. Les complications ophthalmologiques des craniofaciost6nosis. A propos de 224 observations. J Fr Ophtalmol 1986;9:273-280..Google Scholar
  65. 64.
    Duke-Elder S, Dobree JH. Diseases of the retina. In Duke-Elder S, ed. System of Ophthalmology. St Louis, MO: CV Mosby Co; 1967,10:246-248.Google Scholar
  66. 65.
    Dutton JJ. Optic nerve sheath meningioma. Surv Ophthalmol 1992;37:167-183.Google Scholar
  67. 66.
    Ellis W, Little HL. Leukemic infiltration of the optic nerve head. Am J Ophthalmol 1973;75:867-871.Google Scholar
  68. 67.
    Elrazak MA. Brucella optic neuritis. Arch Int Med 1991;151:776-778.Google Scholar
  69. 68.
    Engelken JD, Yuh WTC, Carter KD, Nerad JA. Optic nerve sarcoidosis. MR findings. AJNR 1992;13:228-230.Google Scholar
  70. 69.
    Erkkila H. Optic disc drusen in children. Acta Ophthalmol 1977;129(suppl):7-44.Google Scholar
  71. 70.
    Fanous M, Hamed LM, Margo CE. Pseudotumor cerebri associated with Danazol withdrawal. JAMA 1991;266:1218-1219.Google Scholar
  72. 71.
    Farris BK, Pickard DJ. Bilateral postinfectious optic neuritis and intravenous steroid therapy in children. Ophthalmology 1990;97:339-345.Google Scholar
  73. 72.
    Fewell AG. Unilateral neuroretinitis of syphilitic origin with a striate figure at the macula. Arch Ophthalmol 1932;8:615.Google Scholar
  74. 73.
    Fish RH, Hogan RN, Nightingale SD, Anand R. Peripapillary angiomatosis associated with catscratch neuroretinitis. Arch Ophthalmol 1992; 110:323.Google Scholar
  75. 74.
    Fish RH, Haskins JC, Kline LB. Toxoplasmosis neuroretinitis. Ophthalmology 1993;100: 1177-1182.Google Scholar
  76. 75.
    Fishman MA, Hogan GR, Dodge PR. The concurrence of hydrocephalus and craniosynostosis. J Neurosurg 1971;34:621.Google Scholar
  77. 76.
    Fitz C. Magnetic resonance imaging of pediatric brain tumors. Topics Magnet Reson Imaging 1993;5:174-189.Google Scholar
  78. 77.
    Folk JC, Weingeist TA, Corbett JJ, et al. Syphilitis neuroretinitis. Am J Ophthalmol 1983;95:448-486. 78. Folk JC, Lobes LA. Presumed toxoplasmic papillitis. Ophthalmology 1984;91:64-67.Google Scholar
  79. 79.
    Foster RE, Lowder CY, Meisler DM, et al. Mumps neuroretinitis in an adolescent. Am J Ophthalmol 1990;110:91-93.Google Scholar
  80. 80.
    Francois J. L’her6dite en ophtalmologie. Paris: Masson;1958,509-602.Google Scholar
  81. 81.
    Frey T. Optic neuritis in children: infectious mononucleosis as an etiology. Doc Ophthalmol 1973;34:183-188.Google Scholar
  82. 82.
    Friedman AH, Beckerman B, Gold DH, et al. Drusen of the optic disc. Surv Ophthalmol 1977; 21:375-390.Google Scholar
  83. 83.
    Friedman DH, Gartner S, Modi SS. Drusen of the optic disc. A retrospective study in cadaver eyes. Br J Ophthalmol 1975;59:413-521.Google Scholar
  84. 84.
    Friedman DH, Henkind P, Gartner S. Drusen of the optic disc: a histopathological study. Trans Ophthalmol Soc UK 1975;95:4-9.Google Scholar
  85. 85.
    Fries PD, Katowitz JA. Congenital craniofacial anomalies of ophthalmic importance. Surv Ophthalmol 1990;35:87-119.Google Scholar
  86. 86.
    Frisen L, Scholdstrom G, Svendsen P Drusen in the optic nerve head: verification by computerized tomography. Arch Ophthalmol 1978;96: 1611-1614.Google Scholar
  87. 87.
    Frohman LP, Joshi VV Wagner RS, Bielory L. Pseudotumor cerebri as a cardinal sign of the polyangiitis overlap syndrome. Neuro-ophthalmology 1991;11:337-345.Google Scholar
  88. 88.
    Gass JMD. Diseases of the optic nerve that may simulate macular disease. Trans Am Acad Ophthalmol Otolaryngol 1977;83:763-770.Google Scholar
  89. 89.
    Gass JMD. Stereoscopic Atlas of Macular Diseases: Diagnosis and Treatment. St Louis, MO: CV Mosby;1987:470-475, 746-751.Google Scholar
  90. 90.
    Gass JDM. Steroscopic Atlas of Macular Diseases: Diagnosis and Treatment. 3rd ed. St. Louis, MO: CV Mosby;1990;2:727-767.Google Scholar
  91. 91.
    Gass JDM, Callanan DG, Bowman B. Oral therapy in diffuse unilateral subacute neuroretinitis. Arch Ophthalmol 1992;110:675-680.Google Scholar
  92. 92.
    Gaynon MW, Koh K, Marmor JF, Frankel LR. Retinal folds in the shaken baby syndrome. Am J Ophthalmol 1988;106:423-425.Google Scholar
  93. 93.
    Ghose S. Optic nerve changes in hydrocephalus. Trans Ophthal Soc UK 1983;103:217-220.Google Scholar
  94. 94.
    Giangiacomo J, Khan JA, Levine C, Thompson VM. Sequential cranial computed tomography in infants with retinal hemorrhages. Ophthalmology 1988;95:295-299.Google Scholar
  95. 95.
    Gittinger JW, Asdourian GK. Macular abnormalities in papilledema from pseudotumor cerebri. Ophthalmology 1989;96:192-194.Google Scholar
  96. 96.
    Glaser JS. Heredofamilial disorders of the optic nerve. In: Renie, WA. Goldberg’s Genetic and Metabolic Eye Disease. 2nd ed. Boston, MA: Little, Brown; 1986;483-484.Google Scholar
  97. 97.
    Goldberg MA, Kazacos KR, Boyce WM, et al. Diffuse unilateral subacute neuroretinitis. Morphometric, serologic, and epidemiologic support for Baylisascaris as a causative agent. Ophthalmology 1993;100:1695-1701.Google Scholar
  98. 98.
    Goldberg MF, Scott CI, McKusick VA. Hydrocephalus and papilledema in the Maroteaux-Larry syndrome (Mucopolysaccharidosis Type VI). Am J Ophthalmol 1970;69:969-975.Google Scholar
  99. 99.
    Golnik KC, Marotto ME, Fanous MM, et al. Ophthalmic manifestations of Rochalimaea species. Am J Ophthalmo11994;118:145-151.Google Scholar
  100. 100.
    Good WV, Brodsky MC, Edwards MS, Hoyt WF. Bilateral retinal hamartomas in neurofibromatosis type 2. Br J Ophthalmol 1991;75:190.Google Scholar
  101. 101.
    Grant DN. Benign intracranial hypertension. Arch Dis Child 1971;46:651-655.Google Scholar
  102. 102.
    Greer M. Benign intracranial hypertension. I: mastoiditis and lateral sinus obstruction. Neurology 1962;12:472-476.Google Scholar
  103. 103.
    Greer M. Benign intracranial hypertension: II: following corticosteroid therapy. Neurology 1963;13: 439-441.Google Scholar
  104. 104.
    Greer M. Benign intracranial hypertension: IV: menarche. Neurology 1964;14:569-573.Google Scholar
  105. 105.
    Greer M. Benign intracranial hypertension (pseudotumor cerebri). Pediatr Clin North Am 1967; 14:819-830.Google Scholar
  106. 106.
    Guiseffi V, Wall M, Siegel PZ, Rojas PB. Symptoms and disease associations in idiopathic intracranial hypertension. Neurology 1991; 41:239-244.Google Scholar
  107. 107.
    Guy J, Sherwood M, Day AL. Surgical treatment of progressive visual loss in traumatic optic neuropathy: report of two cases. J Neurosurg 1989; 70:799-801.Google Scholar
  108. 108.
    Hagberg B, Sillanpaa M. Benign intracranial hypertension (pseudotumor cerebri). Acta Paediatr Scand 1970;59:328-329.Google Scholar
  109. 109.
    Haller P, Patzgold U. Die Optikusneuritis im Kindesalter. Fortschr Neurol Psychiatr 1979;47: 209-216.Google Scholar
  110. 110.
    Hamed LM, Purvin VP, Rosenberg M. Recurrent anterior ischemic optic neuropathy in young adults. J Clin Neuro-ophthalmol 1988;8:239-246.Google Scholar
  111. 111.
    Hamed LM, Glaser JS, Schatz NJ, Perez TH. Pseudotumor cerebri induced by Danazol. Am J Ophthalmol 1989;107:105-110.Google Scholar
  112. 112.
    Hamed LM, Silbiger J, Guy J, et al. Parainfectious optic neuritis and encephalomyelitis. J Clin Neuroophthalmol 1993;1:18-23.Google Scholar
  113. 113.
    Harris MJ, Fine SL, Owens S. Hemorrhagic complications of optic nerve drusen. Am J Ophthalmol 1981;92:70-76.Google Scholar
  114. 114.
    Hayreh SS. Optic disc edema in raised intracranial pressure. V: pathogenesis. Arch Ophthalmol 1977; 95:1553-1565.Google Scholar
  115. 115.
    Hayreh SS. Anterior ischemic optic neuropathy. V. optic disc edema as an early sign. Arch Ophthalmo11981;99:1030-1040.Google Scholar
  116. 116.
    Hayreh SS, Servais GE, Virdi PS, et al. Fundus lesions in malignant hypertension. III. arterial blood pressure, biochemical and fundus changes. Ophthalmology 1985;92:45-59.Google Scholar
  117. 117.
    Hayreh SS, Servais GE, Virdi PS. Fundus lesions in malignant hypertension. IV: focal intraretinal periarteriolar transudates. Ophthalmology 1985; 92:60-73.Google Scholar
  118. 118.
    Hayreh SS, Servais GE, Virdi PS. Fundus lesions in malignant hypertension. V: hypertensive o p t i c neuropathy. Ophthalmology 1986;93:74-87.Google Scholar
  119. 119.
    Hayreh SS, Servais GE, Virdi PS. Fundus lesions in malignant hypertension. VI: hypertensive choroidopathy. Ophthalmology 1986;93:1383-1400.Google Scholar
  120. 120.
    Hedges TR. Bilateral visual loss in a child with disc swelling. Surv Ophthalmol 1992;36:424-428. 121. Heidemann DG, Beck RW. Retinitis pigmentosa. A mimic of neurological disease. Surv Ophthalmol 1987;32:45-51.Google Scholar
  121. 122.
    Hiatt RL, Grizzard JT, McNeer P, Jabbour JT. Ophthalmologic manifestations of subacute sclerosing panencephalitis. Trans Am Acad Ophthalmol Otolaryngol 1971;75:344-350.Google Scholar
  122. 123.
    Hierons R, Lyle TK. Bilateral retrobulbar optic neuritis. Brain 1959;82:56-67.Google Scholar
  123. 124.
    Hitchings RA, Corbett JJ, Winkleman J, Schatz NJ. Hemorrhages with optic nerve drusen. Arch Neurol 1976;33:675-677.Google Scholar
  124. 125.
    Hoover DL, Khan JA, Giangiacomo J. Pediatric ocular sarcoidosis. Surv Ophthalmol 1986;30: 215228.Google Scholar
  125. 126.
    Hoover DL, Robb RM, Petersen RA. Optic disc drusen and primary megalencephaly. J Pediatr Ophthalmol Strabis 1989;26:81-85.Google Scholar
  126. 127.
    Horton JC, Garcia EG, Becker EK. Magnetic resonance imaging of leukemic invasion of the optic nerve. Arch Ophthalmol 1992;110:1207-1208.Google Scholar
  127. 128.
    Hoyt WF, Pont ME. Pseudopapilledema. Anomalous elevation of optic disk. Pitfalls in diagnosis and management. JAMA 1962;181:191-196.Google Scholar
  128. 129.
    Hoyt WF, Beeston D. The Ocular Fundus in Neurologic Disease. St Louis, MO: CV Mosby;1966. 130. Hoyt WF, Knight CL. Comparison of congenital disc blurring and incipient papilledema in red-free light-a photographic study. Invest Ophthalmol 1973;12:241-247.Google Scholar
  129. 131.
    Hrisomalos NF, Mansour AM, Jampol LM, et al. Pseudo-combined hamartoma following papilledema. Arch Ophthalmol 1987;105:164-165.Google Scholar
  130. 132.
    Hupp SL, Buckley EG, Byrne SF, et al. Posttraumatic venous obstructive retinopathy associated with enlarged optic nerve sheath. Arch Ophthalmol 1984;102:254-256.Google Scholar
  131. 133.
    Ikkala E, Laitinen L. Papilloedema due to iron deficiency anaemia. Acta Haemat 1963;29:368-370. 134. Ireland B, Corbett JJ, Wallace RB. The search for causes of idiopathic intracranial hypertension. A preliminary case-control study. Arch Neurol 1990;47:315-320.Google Scholar
  132. 134a.
    Jeffrey AR, Buncic JR. The visual outcome of Devic’s neuromyelitic optica in the pediatric population. Presented at the American Association for Pediatric Ophthalmology and Strabismus. Orlando, Florida, April 5-9,1995.Google Scholar
  133. 135.
    Johnson RT. The pathogenesis of acute viral encephalitis and postinfectious encephalomyelitis. J Infect Dis 1987;155:359-364.Google Scholar
  134. 136.
    Johnston I, Hawke S, Halmagyi M, Teo C. The Pseudotumor syndrome: disorders of cerebrospinal fluid circulation causing intracranial hypertension without ventriculomegaly. Arch Neurol 1991;48: 740-747.Google Scholar
  135. 137.
    Josef JM, Burde RM. Anterior ischemic optic neuropathy of the young. J Clin Neuro-ophthalmol 1983;3:137.Google Scholar
  136. 138.
    Karel I, Otradovec J, Peleska M. Fluorescein angiography in circulatory disturbances in drusen of the optic disc. Ophthlmologica 1972;164:449462.Google Scholar
  137. 139.
    Kattah JC, Suski ET, Killen JY, et al. Optic neuritis in systemic lymphoma. Am J Ophthalmol 1980;89: 431-436.Google Scholar
  138. 140.
    Katz B. Swelling in an adult diabetic patient. Surv Ophthalmol 1990;35:158-163.Google Scholar
  139. 141.
    Katz B. Disc edema, transient obscurations of vision, and a temporal fossa mass. Surv Ophthalmol 1991;36:133-140.Google Scholar
  140. 141a.Katz B. Central American mesencephalopathy. Surv Ophthalmo11994;39:253-259.Google Scholar
  141. 142.
    Kaur B, Taylor D. Fundus hemorrhages in infancy. Surv Ophthalmol 1992;37:1-17.Google Scholar
  142. 143.
    Kaye LD, Rothner D, Beauchamp GR, et al. Ocular findings associated with neurofibromatosis type II. Ophthalmology 1992;99:1424-1429.Google Scholar
  143. 144.
    Kazarian E, Gager W. Optic neuritis complicating measles, mumps, and rubella vaccination. Am J Ophthalmo11978;86:544-567.Google Scholar
  144. 145.
    Keane JR. Cysticercosis: unusual neuro-ophthalmologic signs. J Clin Neuro-ophthalmol 1993; 13:194-199.Google Scholar
  145. 146.
    Kennedy C, Carter S. Relation of optic neuritis to multiple sclerosis in children. Paediatrics 1961; 28:377-387.Google Scholar
  146. 147.
    Kennedy C, Carroll FD. Optic neuritis in children. Arch Ophthalmol 1960;63:747-755.Google Scholar
  147. 148.
    Kesler A, Manor RS. Papilloedema and hydrocephalus in spinal cord ependymoma. Br J Ophthalmol 1994;78:313-315.Google Scholar
  148. 149.
    Kilty LA, Hiles DA. Unilateral posterior lenticonus with posterior hyaloid remnant. Am J Ophthalmol 1993;116:104-106.Google Scholar
  149. 150.
    Klintworth G. The neurologic manifestations of osteopetrosis (Albers-Schonberg’s disease). Neurology 1963;13:512.Google Scholar
  150. 151.
    Knight CL, Hoyt WF. Monocular blindness from drusen of the optic disk. Am J Ophthalmol 1972; 73:890-892.Google Scholar
  151. 152.
    Kriss A, Francis DA, Cuendet F, et al. Recovery after optic neuritis in childhood. J Neurol Neurosurg Psychiatry 1988;51:1253.Google Scholar
  152. 153.
    Krumholtz A, Stern BJ, Stern EG. Clinical implications of seizures in neurosarcoidosis. Arch Neurol 1991;48:842-844.Google Scholar
  153. 154.
    Kuroiwa Y Neuromyelitis optica: Devic’s disease, Devic’s syndrome. Handbook of clinical neurology In: Koetsier JC, ed. Demyelinating Diseases. New York, NY: Elsevier Science Publishers BV; 1985; 3(47):397-408.Google Scholar
  154. 155.
    Lamas E, Lobato RD, Esparza J, Escudero L. Dural posterior fossa AVM producing raised sagittal sinus pressure. J Neurosurg 1977;46:804-810.Google Scholar
  155. 156.
    Lambert SR, Johnson TE, Hoyt CS. Optic nerve sheath and retinal hemorrhages associated with the shaken baby syndrome. Arch Ophthalmol 1986; 104:1509-1512.Google Scholar
  156. 157.
    Landau K, Muci-Mendoza R, Dossetor FM, Hoyt WF. Retinal hamartoma in neurofibromatosis 2. Arch Ophthalmol 1990;108:328-329.Google Scholar
  157. 158.
    Lanesche RK, Rucker CW. Progression of visual field defects produced by hyaline bodies in optic discs. Arch Ophthalmol 1957;58:115-121.Google Scholar
  158. 159.
    Leber T. Die pseudonephritischen Netzhauterkrankungen, die Retinitis stellata; die Purtschersche Netzhautaffektion nach schwerer Schadel verletzung. In: Graefe AC, Saemisch T, eds. Graefe-Saemisch-Hess Handbuch der Gesamten Augenheilkunde. 2nd ed. Leipzig, East Germany: Engelmann;1916,7, (pt 2):1319-1339.Google Scholar
  159. 160.
    Lepore FE. Unilateral and highly asymmetric papilledema in pseudotumor cerebri. Neurology 1992; 42:676-678.Google Scholar
  160. 161.
    Lessell S, Rosman NP Permanent visual impairment in childhood pseudotumor cerebri. Arch Neurol 1986;43:801-804.Google Scholar
  161. 162.
    Lessell S. Pediatric pseudotumor cerebri (idiopathic intracranial hypertension). Surv Ophthalmol 1992;37:155-166.Google Scholar
  162. 163.
    Lesser RL, Kornmehl EW, Pachner AR. Neuroophthalmologic manifestations of Lyme disease. Ophthalmology 1990;97:699-706.Google Scholar
  163. 164.
    Lilley ER, Bruggers CS, Pollack SC. Papilledema in a patient with aplastic anemia. Arch Ophthalmol 1990;108:1674-1675.Google Scholar
  164. 165.
    Lorentzen SE. Drusen of the optic disk. Dan Med Bull 1967;14:293-298.Google Scholar
  165. 166.
    Lorentzen SE. Drusen of the optic disk, an irregular dominant hereditary affectation. Arch Ophthalmol 1961;39:626-643.Google Scholar
  166. 167.
    Lubow M, Makley TA. Pseudopapilledema of juvenile diabetes mellitus. Arch Ophthalmol 1971; 85:417-422.Google Scholar
  167. 168.
    Lubow ML. Pseudo pseudotumor cerebri in aplastic anemia. Arch Ophthalmol 1991;109:1638. 169. Lui GT, Kay MD, Bienfang DC. Pseudotumor cerebri associated with inflammatory bowel disease. Am J Ophthalmol 1994;117:352-357.Google Scholar
  168. 170.
    Mandler RN, Davis LE, Jeffery DR, Kornfeld M. Devic’s neuromyelitis optica: a clinicopathological study of 8 patients. Ann Neurol 1993;34:162-168. 171. Mann NP, McLellan NJ, Cartlidge PHT. Transient intracranial hypertension of infancy. Arch Dis Child 1988;63:966-968.Google Scholar
  169. 172.
    Mansour AM. Hamed LM. Racial variation of optic nerve disease. Neuro-ophthalmology 1991;11: 319-323.Google Scholar
  170. 173.
    Marie J, See G. Acute hypervitaminosis A of infant; its clinical manifestations with benign acute hydrocephalus and pronounced bulge of fontanel; clinical and biological study. Am J Dis Child 1954;87:731.Google Scholar
  171. 174.
    Mathew NT, Mayer JS, Ott E0. Increased cerebral blood volume in benign intracranial hypertension. Neurology 1975;25:646-649.Google Scholar
  172. 175.
    Mathur SP. Macular lesion after influenza. Br J Ophthalmol 1958;42:702.Google Scholar
  173. 176.
    Matzkin DC, Slamovits TL, Genis 1, Bello J. Disc swelling: a tall tail? Surv Ophthalmol 1992;37: 130-136.Google Scholar
  174. 177.
    McDonald F, Digre K, Yuh WTC, Corbett JJ. The incidence of empty sella and Chiari 1 malformation in pseudotumor cerebri. Presented as a poster at the North American Neuro-Ophthalmology Society Meeting, Durango, CO, February 1994.Google Scholar
  175. 178.
    Meadows SP Retrobulbar and optic neuritis in childhood and adolescence. Trans Ophthalmol Soc UK 1969;89:603-638.Google Scholar
  176. 179.
    Miller NR, ed. Walsh and Hoyt’s Clinical NeuroOphthalmology, I. Baltimore, MD: Williams & Wilkins Co; 1982Google Scholar
  177. 180.
    Miller NR. Appearance of optic disc drusen in a patient with anomalous elevation of the optic disc. Arch Ophthalmol 1986;104:794-795.Google Scholar
  178. 181.
    Miller NR. Sudden visual field constriction associated with optic disc drusen. J Clin Neuro-ophthalmol 1993;13:14.Google Scholar
  179. 182.
    Minckler DS, Tso MOM, Zimmerman LE. A light microscopic, autoradiographic study of axoplasmic transport in the optic nerve head during ocular hy potony, increased intraocular pressure, and papilledema. Am J Ophthalmol 1976;82:741-757. 183. Minckler DS, Bunt AH. Axoplasmic transport in ocular hypotony and papilledema in the monkey. Arch Ophthalmol 1977;95:1430-1436.Google Scholar
  180. 184.
    Moisseiev J, Cahane M, Treister G. Optic nerve head drusen and peripapillary central serous chorioretinopathy. Am J Ophthalmol 1989;108:202-203. 185. Moody TA, Irvine AR, Cahn PH, et al. Sudden visual field constriction associated with optic disc drusen. J Clin Neuro-ophthalmol 1993;13:8-13.Google Scholar
  181. 186.
    Morris AT, Sanders MD. Macular changes resulting from papilloedema. Br J Ophthalmol 1980; 64:211-216.Google Scholar
  182. 187.
    Morrissey SP, Miller DH, Kendall BE, et al. The significance of brain magnetic resonance imaging abnormalities at presentation with clinically iso lated syndromes suggestive of multiple sclerosis. Brain 1993;116:135-146.Google Scholar
  183. 188.
    Moser FG, Hilal SK, Abrams G, et al. MR imaging of pseudotumor cerebri. AJNR 1988;9:39-45.Google Scholar
  184. 189.
    Mueller RF, Pagon RA, Pepin MG, et al. Arteriohepatic dysplasia: phenotypic features and family studies. Clin Genet 1984;25:323-331.Google Scholar
  185. 190.
    Mullie MA. Sanders MD. Scleral canal size and optic nerve head drusen. Am J Ophthalmol 1985; 99:356-359.Google Scholar
  186. 191.
    Mustonen E. Pseudopapilledema with and without verified optic disc drusen: A clinical analysis. II. visual fields. Acta Ophthalmnol 1979;61:1057-1066.Google Scholar
  187. 192.
    Mustonen E. Pseudopapilloedema with and without verified optic disc drusen. A clinical analysis 1. Acta Ophthalmol 1983;61:1037-1056.Google Scholar
  188. 193.
    Mustonen E. Pseudopapilloedema with and without verified optic disc drusen. A clinical analysis 11: visual fields. Acta Ophthalmol 1983;61:10571066.Google Scholar
  189. 194.
    Newman NJ, Lessell S, Brandt EM. Bilateral central retinal artery occlusions, disc drusen, and migraine. Am J Ophthalmol 1989;107:236-240.Google Scholar
  190. 195.
    Newman NJ. Leber’s hereditary optic neuropathy. New genetic considerations. Arch Neurol 1993; 50:540-548.Google Scholar
  191. 196.
    Nikaido H, Mishima H, Ono H. Leukemic involvement of the optic nerve. Am J Ophthalmol 1988;105:294-298.Google Scholar
  192. 197.
    Nikoskelainen E, Hoyt WF, Nummelin K. Ophthalmoscopic findings in Leber’s hereditary optic neuropathy. II. the fundus findings in the affected fam ily members. Arch Ophthalmol 1983;101: 1059-1068.Google Scholar
  193. 198.
    Novakovic P, Kellie SJ, Taylor D. Childhood leukaemia: relapse in the anterior segment of the eye. Br J Ophthalmol 1989;73:354-359.Google Scholar
  194. 199.
    Nyboer JH, Robertson DM, Gomez MR. Retinal lesions in tuberous sclerosis. Arch Ophthalmol 1976;94:1277-1280.Google Scholar
  195. 200.
    Ohkoshi K, Tsiaras WG. Prognostic importance of ophthalmic manifestations in childhood leukaemia. Br J Ophthalmol 1992;76:651-655.Google Scholar
  196. 201.
    Optic Neuritis Study Group: The clinical profile of optic neuritis: experience of the Optic Neuritis Treatment Trial. Arch Ophthalmol 1991;109: 1673-1678.Google Scholar
  197. 202.
    Ormerod IEC, McDonald WI, du Boulay GH, et al. Disseminated lesions at presentation in patients with optic neuritis. J Neurol Neurosurg Psychiatr 1986;49:124-127.Google Scholar
  198. 203.
    Parmley VC, Schiffman JS, Maitland CG, et al. Does neuroretinitis rule out multiple sclerosis? Arch Neurol 1987;44:1045-1047.Google Scholar
  199. 204.
    Pavin PR, Aiello LM, Wafai Z, et al. Optic disc edema in juvenile-onset diabetes. Arch Ophthalmol 1980;98:2193-2195.Google Scholar
  200. 205.
    Petersen RA, Rosenthal A. Retinopathy and papilledema in cyanotic congenital heart disease. Pediatrics 1972;49:243-249.Google Scholar
  201. 206.
    Pickens S, Sangster G. Retrobulbar neuritis and infectious mononucleosis. Br Med J 1975;4:729. 207. Piel A Thelander HE, Shaw EB. Infectious mononucleosis of the central nervous system with bilateral papilledema. J Pediatr 1950;37:661-665. 208. Pillai S, Limaye SR, Saimovici LB. Optic disc hamartoma associated with retinitis pigmentosa. Retina 1983;3:24-26.Google Scholar
  202. 209.
    Pollard ZF. Cysticercosis: an unusual cause of papilledema. Ann Ophthalmol 1975;7:110-112.Google Scholar
  203. 210.
    Puck A, Tso MOM, Fishman GA. Drusen of the optic nerve associated with retinitis pigmentosa. Arch Ophthalmol 1985;103:231-234.Google Scholar
  204. 211.
    Purcell JJ, Goldberg RE. Hyaline bodies of the optic papilla and bilateral acute vascular occlusions. Ann Ophthalmol 1974;6:1069-1076.Google Scholar
  205. 212.
    Purvin V Herr GJ, Myer W. Chiasmal neuritis as a complication of Epstein-Barr virus infection. Arch Neurol 1988;45:458-460.Google Scholar
  206. 213.
    Raichle ME, Grubb RL, Phelps ME, et al. Cerebral hemodynamics and metabolism in pseudotumor cerebri. Ann Neuro11978;4:104-111.Google Scholar
  207. 214.
    Regnery RL, Olsen JG, Perkins BA, Bibb W. Serological response to Rochalimaea henselae antigen in suspected cat-scratch disease. Lancet 1992;339:1443-1445.Google Scholar
  208. 215.
    Rennie I. Ophthalmic manifestations of childhood leukaemia. Br J Ophthalmol 1992;76:641.Google Scholar
  209. 216.
    Ridgeway EW, Jaffe N, Walton DS. Leukemic ophthalmopathy in children. Cancer 1976;38: 1744-1749.Google Scholar
  210. 217.
    Riikonen R, Donner M, Errkila H. Optic neuritis in children and its relationship to multiple sclerosis. A clinical study of 21 children. Dev Med Child Neuro11988;30:349-359.Google Scholar
  211. 218.
    Riikonen R, Ketonen L, Sipponen J. Magnetic resonance imaging, evoked responses and cerebrospinal fluid findings in a follow-up study of children with optic neuritis. Acta Neurol Scand 1988;77:44-49.Google Scholar
  212. 219.
    Riikonen R, von Willebrandt E. Lymphocyte subclasses and function in patients with optic neuritis in childhood with special reference to multiple sclerosis. Acta Neurol Scand 1988;78:58-64.Google Scholar
  213. 220.
    Riikonen R. The role of infection and vaccination in the genesis of optic neuritis and multiple sclerosis in children. Acta Neurol (Scand) 1989;80: 425431.Google Scholar
  214. 221.
    Rizzo JF, Lessell S. Risk of developing multiple sclerosis after uncomplicated optic neuritis. A long-term prospective study. Neurology 1988;38: 185-190.Google Scholar
  215. 222.
    Roach ES, Zimmerman CF, Troost BT, Weaver RG. Optic neuritis due to acquired toxoplasmosis. Pediatr Neurol 1985;1:114-116.Google Scholar
  216. 223.
    Romanchuk KG, Judisch GF, LaBrecque DR. Ocular findings in arteriohepatic dysplasia (Alagille’s syndrome). Can J Ophthalmo11981;16:94-99.Google Scholar
  217. 224.
    Rose A, Matson DD. Benign intracranial hypertension in children. Pediatrics 1967;39:227-232.Google Scholar
  218. 225.
    Rosenberg MA, Savino PJ, Glaser JS. A clinical analysis of pseudopapilledema: I: population, laterality, acuity, refractive error, ophthalmoscopic characteristics, and coincident disease. Arch Ophthalmol 1979;97:65-70.Google Scholar
  219. 226.
    Rosenthal AR. Ophthalmic manifestations of leukemia: a review. Ophthalmology 1983;90: 899905.Google Scholar
  220. 227.
    Rozot P, Berrod JP, Bracard S, et al. Stase papillaire et fistule durale. J Fr Ophtalmol 1991;14: 1319.Google Scholar
  221. 228.
    Ruben JB, Morris RJ, Judisch GF. Chorioretinal degeneration in infantile malignant osteoporosis. Am J Ophthalmol 1990;110:1-5.Google Scholar
  222. 229.
    Rush JA. Idiopathic optic neuritis of childhood. J Pediatr Ophthalmol Strabis 1981;18:39-41.Google Scholar
  223. 230.
    Sacks JG, O’Grady RB, Choromokos E, Leestma J. The pathogenesis of optic nerve drusen. A hypothesis. Arch Ophthalmol 1977;95:425-428.Google Scholar
  224. 231.
    Salmon JF, Lee Pan E, Murray ADN. Visual loss with dancing extremities. Surv Ophthalmol 1991; 35:299-306.Google Scholar
  225. 232.
    Sanders MD, Ffytche TJ. Flourescein angiography in the diagnosis of drusen of the disc. Trans Ophthalmol Soc UK 1967;87:457-468.Google Scholar
  226. 233.
    Sanders TE, Gay AJ, Newman M. Hemorrhagic complications of drusen of the optic disk. Am J Ophthalmol 1971;71:204-217.Google Scholar
  227. 234.
    Sarkies NJC, Sanders MD. Optic disc drusen and episodic visual loss. Br J Ophthalmol 1985;71: 537-539.Google Scholar
  228. 235.
    Savage GL, Centaro A, Enoch JM, Newman NM. Drusen of the optic nerve head. Ophthalmology 1985;92:793-799.Google Scholar
  229. 236.
    Savino PJ, Glaser JS, Rosenberg MA. A clinical analysis of pseudopapilledema. II: visual field defects. Arch Ophthlamol 1979;97:71-75.Google Scholar
  230. 237.
    Schachat AP, Markowitz JA, Guyer DR, et al. Ophthalmic manifestations of leukemia. Arch Ophthalmol 1989;107:697-700.Google Scholar
  231. 238.
    Schnittger S, H6fers C, Heidemann P, et al. Molecular and cytogenetic analysis of an interstitial 20p deletion associated with syndromic intrahepatic ductular hypoplasia (Alagille syndrome). Hum Genet 1989;83:239-244.Google Scholar
  232. 239.
    Schoeman JF. Childhood pseudotumor cerebri: clinical and intracranial pressure response to acetazolamide and furosemide treatment in a case series. J Child Neuro11994;9:1301-1334.Google Scholar
  233. 240.
    Scott TF. Neurosarcoidosis: progress and clinical aspects. Neurology 1993;43:8-12.Google Scholar
  234. 241.
    Sedwick LA, Burde RM. Unilateral and asymmetric optic disk swelling with intracranial abnormalities. Am J Ophthalmol 1983;96:484-487.Google Scholar
  235. 242.
    Seitz R, Kersting G. Die drusen der sehnervenpapille and des pigmentphitels. Klin Monatsbl Augenheilkd 1962;140:75-88.Google Scholar
  236. 243.
    Seitz R. Die intraocular drusen. Klin Monatsbl Augenheilkd 1968;152:203.Google Scholar
  237. 244.
    Selbst RG, Selhorst JB, Harbison JW, Myer EC. Parainfectious optic neuritis: report and review following varicella. Arch Neuro11983;40:347-350.Google Scholar
  238. 245.
    Selky AK, Dobyns WB, Yee RD. Idiopathic intracranial hypertension and facial diplegia. Neurology 1994;44.Google Scholar
  239. 246.
    Seltzer S, Mark AS, Atlas SW. CNS sarcoidosis: evaluation with contrast-enhanced MR imaging. AJNR 1992;12:1227-1232.Google Scholar
  240. 247.
    Shaked Y, Samra Y. Q fever meningoencephalitis associated with bilateral abducens nerve paralysis, bilateral optic neuritis, and abnormal cerebrospinal fluid findings. Infection 1989;17:394-395.Google Scholar
  241. 248.
    Sharma OP, Sharma AM. Sarcoidosis of the nervous system. A clinical approach. Arch Intern Med 1991;151:1317-1321.Google Scholar
  242. 249.
    Shulman SA, Hyams JS, Gunta R, et al. Arteriohepatic dysplasia (Alagille syndrome): extreme variability among affected family members. Am J Med Genet 1984;19:325-332.Google Scholar
  243. 250.
    Silbergleit R, Junck L, Gebarski SS, Hatfield MK. Idiopathic intracranial hypertension (pseudotumor cerebri): MR imaging. Neuroradiology 1989;170: 207-209.Google Scholar
  244. 251.
    Silbiger J, Guy JR. Lethargy and visual loss in a child. Presented at the 23rd Annual Frank B. Walsh Society meeting, Park City, Utah, 1991.Google Scholar
  245. 252.
    Silverstein A, Steinberg G, Nathanson M. Nervous system involvement in infectious mononucleosis. Arch Neurol 1972;26:353-358.Google Scholar
  246. 253.
    Singleton EM, Kinsbourne M, Anderson WB. Familial pseudopapilledema. South Med J 1973;66: 796-802.Google Scholar
  247. 254.
    Sivalingam A, Augsburger J, Perilongo G, et al. Combined hamartoma of the retina and retinal pigment epithelium in a patient with neurofibromato sis type 2. J Pediatr Ophthalmol Strabis 1991;28: 320-321.Google Scholar
  248. 255.
    Slavin ML. Chronic asymptomatic ischemic optic neuropathy. J Clin Neuro-ophthalmol 1987;7: 198201.Google Scholar
  249. 256.
    Smith JL, Hoyt WF, Susac JO. Ocular fundus in acute Leber optic neuropathy. Arch Ophthalmol 1973;90:349-354.Google Scholar
  250. 257.
    Sorenson PS, Thomsen C, Gjerris F, et al. Increased brain water content in pseudotumor cerebri measured by magnetic resonance imaging of brain water self-diffusion. Neurol Res 1989;11:160-164. 258. Spencer WH. Drusen of the optic disc and aberrant axoplasmic transport. Am J Ophthalmol 1978; 85:1-12.Google Scholar
  251. 259.
    Steere AC, Taylor E, McHugh GL, Logigian EL. The overdiagnosis of Lyme disease. JAMA 1993; 269:1812-1816.Google Scholar
  252. 260.
    Stevens RA, Newman NM. Abnormal visualevoked potentials from eyes with optic nerve head drusen. Am J Ophthalmol 1981;92:857-862.Google Scholar
  253. 261.
    Straussberg R, Amir J, Cohen HA, et al. EpsteinBarr virus infection associated with encephalitis and optic neuritis. J Pediatr Ophthalmol Strabis 1993;30:262-263.Google Scholar
  254. 262.
    Strong LE, Henderson JW, Gangitano JL. Bilateral retrobulbar neuritis secondary to mumps. Am J Ophthalmol 1974;78:331-335.Google Scholar
  255. 263.
    Suh DC, Chang KH, Han MH, et al. Unusual MR manifestations of neurocysticercosis. Neuroradiology 1989;31:396-402.Google Scholar
  256. 264.
    Symonds CP. Otitic hydrocephalus. Brain 1931; 54:55.Google Scholar
  257. 265.
    Taha JM, Crone KR, Berger TS, et al. Sigmoid sinus thrombosis after closed head injury in children. Neurosurgery 1993;32:541-546.Google Scholar
  258. 266.
    Taylor D, Cuendet F. Optic neuritis in childhood. In: Hess RF, Plant GT, eds. Optic Neuritis. Cambridge: Cambridge University Press; 1986:73-85. 267. Taylor D. Pediatric Ophthalmology. Boston, MA: Blackwell Scientific Publications; 1990:213-222. 268. Tso MOM, Fine BS. Electron microscopic study of human papilledema. Am J Ophthalmol 1976;82: 424-434.Google Scholar
  259. 269.
    Tso MOM. Pathology and pathogenesis of drusen of the optic nervehead. Ophthalmology 1981;88: 1066-1080.Google Scholar
  260. 270.
    Ulrich GG, Waecker NJ, Meister SJ, et al. Cat scratch disease associated with neuroretinitis in a 6-year-old girl. Ophthalmology 1992;99:246–249.PubMedGoogle Scholar
  261. 269.
    Usai T, Shirakashi M, Takagi M, et al. Macular edema-like change and pseudopapilledema in a case of Scheie syndrome. J Clin Neuro-ophthalmol 1991;11:183–185.CrossRefGoogle Scholar
  262. 272.
    Wang XJ, Chang WM, Lee HL, Chang RF, Xu YZ. Fundus changes in 120 cases of aplastic anemia. Chang-Hua Yen Kotsa Chih 1985;21:344–346.Google Scholar
  263. 273.
    Webb NR, McCrary JA. Hyaline bodies of the optic disc and migraine. In: Smith JL, ed. NeuroOphthalmology Update. New York, NY: Masson Publishing USA, Inc; 1977:155–162.Google Scholar
  264. 274.
    Weisberg JA, Chutorian AM. Pseudotumor cerebri of childhood. Am J Dis Child. 1977;131: 1243–1248.PubMedGoogle Scholar
  265. 275.
    Weisberg LA, Pierce JF, Jabbari B. Intracranial hypertension resulting from a cerebrovascular malformation. South Med J 1977;70:624–626.PubMedCrossRefGoogle Scholar
  266. 276.
    Weiss AH, Beck RW Neuroretinitis in childhood. J Pediatr Ophthalmol Strabis 1989;26:198–203.Google Scholar
  267. 277.
    Welch DF, Pickett DA, Slater LN, et al. Rochalimaea henselae sp. nov., a cause of septicemia, bacillary angiomatosis, and parenchymal bacillary peliosis. J Clin Microbiol 1992;30:275–280.PubMedGoogle Scholar
  268. 278.
    Wilkinson WS, Han DP, Rappley MD, Owings CL. Retinal hemorrhages predicts neurological injury in the shaken baby syndrome. Arch Ophthalmol 1989;197:1472–1474.Google Scholar
  269. 279.
    Williams R, Taylor D. Tuberous sclerosis. Surv Ophthalmol 1985;30:143–154.PubMedCrossRefGoogle Scholar
  270. 280.
    Wilson CB, Hieshima G. Occlusive hyperemia: a new way to think about an old problem. J Neurosurg 1993;78:165–166.PubMedCrossRefGoogle Scholar
  271. 281.
    Winrow AP, Supramaniam G. Benign intracranial hypertension after ciprofloxacin. Arch Dis Child 1990;65:1165–1166.PubMedCrossRefGoogle Scholar
  272. 282.
    Winterkorn JMS. Lyme disease: neurological and ophthalmic manifestations. Surv Ophthalmology 1990;35:191–204.CrossRefGoogle Scholar
  273. 283.
    Winterkorn J. Presented at the Frank B. Walsh Society Meeting, New York, NY, March 1993.Google Scholar
  274. 284.
    Winward KE, Smith JL, Culbertson WW, ParisHamelin A. Ocular lyme borreliosis. Am J Ophthalmol 1989;108:651–657.PubMedGoogle Scholar
  275. 285.
    Wirtschafter JD. Osteopetrosis-A rare disease: a new treatment. Presented to the North American Neuro-Ophthalmology Society, Steamboat Springs, CO, February 1990.Google Scholar
  276. 286.
    Wise GN, Henkind P, Alterman GM. Optic disc drusen and subretinal hemorrhage. Trans Am Acad Ophthalmol Otolaryngol 1974;78:212–219.Google Scholar
  277. 287.
    Wright JE, McNab AA, McDonald WI. Primary optic nerve sheath meningioma. Br J Ophthalmol 1989;73:960–966.PubMedCrossRefGoogle Scholar
  278. 288.
    Yohai RA, Bullock JD, Margolis JH. Unilateral optic disc edema and a contralateral temporal fossa mass. Am J Ophthalmol 1993;155:262–264.Google Scholar
  279. 289.
    Young WO, Small KW. Pigmented paravenous retinochoroidal atrophy (PPRCA) with optic disc drusen. Ophthal Pediatr Genet 1993;1:23–29.CrossRefGoogle Scholar
  280. 290.
    Zhang F, Deleuze JR, Aurias A, et al. Interstitial deletion of the short arm of chromosome 20 in arteriohepatic dysplasia (Alagille syndrome). J Pediatr 1990;116:73–77.PubMedCrossRefGoogle Scholar
  281. 291.
    Zouaoui A, Maillard JC, Dormaont D, et al. Apport de firm dans la neurosarcoidose: MRI in neurosarcoidosis. J Neuroradiol 1992;19:271–284271–284.PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York, Inc. 1996

Authors and Affiliations

  • Michael C. Brodsky
    • 1
    • 2
  • Robert S. Baker
    • 3
  • Latif M. Hamed
    • 4
  1. 1.Jones Eye InstituteUniversity of Arkansas for Medical SciencesLittle RockUSA
  2. 2.Arkansas Children’sHospital Little RockUSA
  3. 3.University of Kentucky Medical CenterLexingtonUSA
  4. 4.Section of Pediatric OphtalmologyUniversity of Florida College of MedicineGainesvilleUSA

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