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Actin Polymerization and Gel Osmotic Swelling in Tumor Cell Pseudopod Formation

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Cell Mechanics and Cellular Engineering

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Abstract

Active tumor cell motility has long been appreciated to play a major role in invasion and metastasis. Tumor cells exhibit an amoeboid movement similar to that of polymorphonuclear (PMN) leukocytes and the lower eukaryote Dictyostelium, characterized by pseudopod protrusion at the leading edge of the cell (Oster and Perelson 1987; Guirguis et al 1987; Condeelis 1992; Condeelis et al 1988, 1990, 1992; Stossel 1989, 1990, 1993; Usami et al 1992; Liotta 1992). Most of the current knowledge of mechanisms of amoeboid Chemotaxis is derived from studies of PMN leukocytes and Dictyostelium amoebae, which have revealed many similarities between the two different eukaryotic models.

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Authors
  1. C. Dong
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  2. J. You
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  3. S. Aznavoorian
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  4. D. Savarese
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  5. L. A. Liotta
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Editor information

Editors and Affiliations

  1. Orthopaedic Research Laboratory, Columbia University, 630 W. 168th Street, New York, NY, 10032, USA

    Van C. Mow

  2. Department of Aerospace Engineering, Mechanics and Engineering Science, University of Florida, Gainesville, FL, 32611, USA

    Roger Tran-Son-Tay

  3. Musculo-Skeletal Research Laboratory, Department of Orthopaedics, Health Science Center, State University of New York, Stony Brook, NY, 11794, USA

    Farshid Guilak

  4. Department of Mechanical Engineering and Material Sciences, Duke University, Durham, NC, 27708, USA

    Robert M. Hochmuth

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© 1994 Springer-Verlag New York, Inc.

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Dong, C., You, J., Aznavoorian, S., Savarese, D., Liotta, L.A. (1994). Actin Polymerization and Gel Osmotic Swelling in Tumor Cell Pseudopod Formation. In: Mow, V.C., Tran-Son-Tay, R., Guilak, F., Hochmuth, R.M. (eds) Cell Mechanics and Cellular Engineering. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8425-0_28

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  • DOI: https://doi.org/10.1007/978-1-4613-8425-0_28

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-8427-4

  • Online ISBN: 978-1-4613-8425-0

  • eBook Packages: Springer Book Archive

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