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Stress, Strain, Pressure and Flow Fields in Articular Cartilage and Chondrocytes

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Cell Mechanics and Cellular Engineering

Abstract

Articular cartilage serves as the load-bearing material of joints, with excellent friction, lubrication and wear characteristics (Mow et al. 1992a). Under normal physiological conditions, these essential biomechanical functions are provided with little or no degenerative changes over the lifetime of a human joint. However, biomechanical factors such as excessively high impact loads, repetitively applied loads, joint immobilization and instability, and abnormal range of motion can alter the composition, structure and material properties of articular cartilage (e.g., Armstrong et al. 1985; Caterson and Lowther 1978; Donohue et al. 1983; Helminen et al. 1987; Palmoski et al. 1979–1981; Vener et al. 1992). These changes in the biochemical composition and material properties are due, in part, to the alterations in the metabolic activities of the chondrocytes attempting to remodel articular cartilage in an effort to adapt to their new biomechanical environment (e.g., Helminen et al. 1987; Howell et al. 1992; Stockwell 1979).

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Authors
  1. V. C. Mow
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  2. N. M. Bachrach
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  3. L. A. Setton
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  4. F. Guilak
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Editor information

Editors and Affiliations

  1. Orthopaedic Research Laboratory, Columbia University, 630 W. 168th Street, New York, NY, 10032, USA

    Van C. Mow

  2. Department of Aerospace Engineering, Mechanics and Engineering Science, University of Florida, Gainesville, FL, 32611, USA

    Roger Tran-Son-Tay

  3. Musculo-Skeletal Research Laboratory, Department of Orthopaedics, Health Science Center, State University of New York, Stony Brook, NY, 11794, USA

    Farshid Guilak

  4. Department of Mechanical Engineering and Material Sciences, Duke University, Durham, NC, 27708, USA

    Robert M. Hochmuth

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© 1994 Springer-Verlag New York, Inc.

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Mow, V.C., Bachrach, N.M., Setton, L.A., Guilak, F. (1994). Stress, Strain, Pressure and Flow Fields in Articular Cartilage and Chondrocytes. In: Mow, V.C., Tran-Son-Tay, R., Guilak, F., Hochmuth, R.M. (eds) Cell Mechanics and Cellular Engineering. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8425-0_20

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  • DOI: https://doi.org/10.1007/978-1-4613-8425-0_20

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