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Uterine Epithelial GM-CSF and Its Interlocutory Role During Early Pregnancy in the Mouse

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Book cover Immunobiology of Reproduction

Part of the book series: Serono Symposia, USA ((SERONOSYMP))

Abstract

It is now recognized that the murine uterine epithelium has an extraordinary capacity to synthesize and release a range of lymphohemopoietic cytokines. Recent studies have shown that these cytokines are produced in a precisely orchestrated sequence during the reproductive cycle and are important components of the intercellular signaling language mediating in the actions of steroid hormones in reproductive tissues (1). Cytokines produced during the dramatic remodeling events of early pregnancy are postulated to have key roles in communication between resident cells and trafficking leukocytes in the endometrium and the developing conceptus. In this chapter we review our findings regarding the production and roles of granulocyte macrophage colony stimulating factor (GM-CSF) during the preimplantation period of murine pregnancy. We provide evidence that GM-CSF originating within the epithelium acts to coordinate local leukocyte participation, both in tissue remodeling and in modulating the local immune milieu to accommodate invasion by semiallogeneic fetal tissue. Nonhemopoietic cells, including the developing embryo, may provide additional targets for the action of this pleiotrophic cytokine.

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Authors
  1. Sarah A. Robertson
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  2. Anna C. Seamark
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  3. Robert F. Seamark
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Editor information

Editors and Affiliations

  1. Department of Anatomy and Cell Biology and Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, 66160, USA

    Joan S. Hunt Ph.D. (Chairman) (Chairman)

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© 1994 Springer-Verlag New York, Inc.

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Robertson, S.A., Seamark, A.C., Seamark, R.F. (1994). Uterine Epithelial GM-CSF and Its Interlocutory Role During Early Pregnancy in the Mouse. In: Hunt, J.S. (eds) Immunobiology of Reproduction. Serono Symposia, USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8422-9_6

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  • DOI: https://doi.org/10.1007/978-1-4613-8422-9_6

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-8424-3

  • Online ISBN: 978-1-4613-8422-9

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