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Antiphospholipid Antibodies and Placental Development

  • Conference paper
Immunobiology of Reproduction

Part of the book series: Serono Symposia, USA ((SERONOSYMP))

Abstract

The antiphospholipid antibody syndrome (aPL syndrome) is characterized by elevated levels of autoantibodies against negatively charged phospholipids (aPLs) associated with several severe obstetrical complications, including recurrent pregnancy loss, pregnancy-induced hypertension and preeclampsia before 34 weeks’gestation, and intrauterine growth retardation (reviewed in 1, 2). The syndrome appears to be a prothrombotic state in which the patients are at risk for thrombosis at virtually any site. The most thoroughly studied aPLs are the lupus anticoagulant and antibodies against the phospholipid cardiolipin (aCLs). It is commonly proposed that aCLs, which are cross-reactive with other phospholipids, are primarily responsible for the thrombosis. The obstetric complications have been attributed to aCL-induced placental damage resulting from placental or decidual thrombosis.

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Authors
  1. Neal S. Rote
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  2. Timothy W. Lyden
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  3. Elizabeth Vogt
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  4. Ah Kau Ng
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Editor information

Editors and Affiliations

  1. Department of Anatomy and Cell Biology and Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, 66160, USA

    Joan S. Hunt Ph.D. (Chairman) (Chairman)

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© 1994 Springer-Verlag New York, Inc.

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Rote, N.S., Lyden, T.W., Vogt, E., Ng, A.K. (1994). Antiphospholipid Antibodies and Placental Development. In: Hunt, J.S. (eds) Immunobiology of Reproduction. Serono Symposia, USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8422-9_18

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  • DOI: https://doi.org/10.1007/978-1-4613-8422-9_18

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-8424-3

  • Online ISBN: 978-1-4613-8422-9

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