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Pathogenesis of Pelvic Pain in Endometriosis

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Endometriosis

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Abstract

Endometriosis is associated with a variety of pain symptoms. Despite the strong clinical correlation, however, the pathophysiology of this association is not well understood. Appearance, location, depth of invasion, and other factors may all influence symptoms.

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References

  1. Stripling M, Martin D, Chatman D, et al. Subtle appearance of pelvic endometriosis. Fertil Steril 1988;49:427–431.

    PubMed  CAS  Google Scholar 

  2. Martin D, Hubert G, Vander Zwaag R, et al. Laparoscopic appearances of peritoneal endometriosis. Fertil Steril 1989;51:63–67.

    PubMed  CAS  Google Scholar 

  3. Jansen R, Russell P. Nonpigmented endometriosis: clinical, laparoscopic, and pathologic definition. Am J Obstet Gynecol 1986;155:1154–1159.

    PubMed  CAS  Google Scholar 

  4. Rapkin A. Neuroanatomy, neurophysiology, and neuropharmacology of pelvic pain. Clin Obstet Gynecol 1990; 33:119–129.

    Article  PubMed  CAS  Google Scholar 

  5. Pomeranz B, Wall P, Wever W. Cord cells responding to fine myelinated afferents from visceral, muscle and skin. J Physiol 1968;199:511–532.

    PubMed  CAS  Google Scholar 

  6. Counsellor V. The treatment of dysmenorrhea by resection of the presacral nerves: evaluation of end results. Am J Obstet Gynecol 1934;28:161–167.

    Google Scholar 

  7. Gray H. Anatomy: Descriptive and surgical. In Pick T, Howden R, eds. (XV ed.) New York, Bounty Books, 1977, 1257.

    Google Scholar 

  8. Fliegner J, Umstad M. Presacral Neurectomy—A reappraisal. Aust NZ J Obstet Gynecol 1991;31:76–79.

    Article  CAS  Google Scholar 

  9. Melzack R. Neurophysiological foundations of pain. In Sternbach R, ed. The psychology of pain. 2nd ed. New York, Raven Press, 1986, 1–24.

    Google Scholar 

  10. Badaway S, Freedman L, Numann P, Bonaventura M, Kim, S. Diagnosis and management of intestinal endometriosis: A report of five cases. J of Reprod Med 1988; 33:851–855.

    Google Scholar 

  11. Kerr WJ. Endometriosis involving the urinary tract. Clin Obstet Gynecol 1966;9:331–357.

    Article  PubMed  Google Scholar 

  12. Horsfield K. Catamenial pleural pain. Eur Respir J 1989; 2:1013–1014.

    PubMed  CAS  Google Scholar 

  13. Vercillini P, Fedele L, Molteni P, Arcaini L, Bianchi S, Candiani G. Laparoscopy in the diagnosis of gynecologic chronic pelvic pain. Int J Gynaecol Obstet 1990;32:261–265.

    Article  Google Scholar 

  14. Chatman D, Zbella E. Pelvic peritoneal defects and endometriosis: Further observations. Fertil Steril 1986;46:711–714.

    PubMed  CAS  Google Scholar 

  15. Goldstein D, deCholnoky C, Emans S, et al. Laparoscopy in the diagnosis and management of pelvic pain adolescents. J Reprod Med 1980;24:251–256.

    PubMed  CAS  Google Scholar 

  16. DeBrux J, Bret J, Demay C, Bardiaux M. Recurring pelvic peritonitis. Amer J Obstet Gynecol 1968;102:501–505.

    CAS  Google Scholar 

  17. Barbieri R. Etiology and epidemiology of endometriosis. Am J Obstet Gynecol 1990;162:565–567.

    PubMed  CAS  Google Scholar 

  18. Kresch A, Seifer D, Sachs L, Barrese I. Laparoscopy in 100 women with chronic pelvic pain. Obstet Gynecol 1984;64:672–674.

    PubMed  CAS  Google Scholar 

  19. Wheeler J, Malinak L. Epidemiology of endometri-osisassociated infertility. J Reprod Med 1989;34:41–46.

    PubMed  CAS  Google Scholar 

  20. Boling R, Abbasi R, Ackerman G, et al. Disability from endometriosis in the United States Army. J Reprod Med 1988;33:49–52.

    PubMed  CAS  Google Scholar 

  21. Ripps B, Martin D. Focal pelvic tenderness, pelvic pain and dysmenorrhea in endometriosis. J Reprod Med 1991; 36:470–472.

    PubMed  CAS  Google Scholar 

  22. Liu D, Hitchcock A. Endometriosis: Its association with retrograde menstruation, dysmenorrhea and tubal pathology. Br J Obstet Gynaecol 1986;93:859–862.

    Article  PubMed  CAS  Google Scholar 

  23. Fedele L, Parazzini F, Bianchi S, et al. Stage and localization of pelvic endometriosis and pain. Fertil Steril 1990; 53:155–158.

    PubMed  CAS  Google Scholar 

  24. Fedele L, Bianchi S, Bocciolone L, et al. Pain symptoms associated with endometriosis. Obstet Gynecol 1992;79: 767–769.

    PubMed  CAS  Google Scholar 

  25. Mahmood T, Templeton A, Thomason L, et al. Menstrual symptoms in women with pelvic endometriosis. Br J Obstet Gynecol 1991;98:558–563.

    Article  CAS  Google Scholar 

  26. Shaw R. Nafarelin in the treatment of pelvic pain caused by endometriosis. Am J Obstet Gynecol 1990;162:574–576.

    PubMed  CAS  Google Scholar 

  27. Buttram VJ. Conservative surgery for endometriosis in the infertile female: A study of 206 patients with implications for both medical and surgical therapy. Fertil Steril 1979;31:117–121.

    PubMed  Google Scholar 

  28. Garcia C, David S. Pelvic endometriosis: infertility and pelvic pain. Am J Obstet Gynecol 1977;129:740–747.

    PubMed  CAS  Google Scholar 

  29. Ranney B. Endometriosis: Conservative operations. Am J Obstet Gynecol 1970;107:743–750.

    PubMed  CAS  Google Scholar 

  30. Williams T, Pratt J. Endometriosis in 1000 consecutive celiotomies: Incidence and management. Am J Obstet Gynecol 1977;129:245–250.

    PubMed  CAS  Google Scholar 

  31. Vercellini P, Bocciolone L, Vendola N, et al. Peritoneal endometriosis. Morphologic appearance in women with chronic pelvic pain. J Reprod Med 1991;36:533–536.

    PubMed  CAS  Google Scholar 

  32. Galle P. Clinical presentation and diagnosis of endometriosis. In: Obstet Gynecol Clin North Am 1989;16:29–42.

    PubMed  CAS  Google Scholar 

  33. Fedele L, Marchini M, Acaia B, et al. Dynamics and significance of placebo response in primary dysmenorrhea. Pain 1989;36:43–47.

    Article  PubMed  CAS  Google Scholar 

  34. Slocumb J. Operative management of chronic abdominal pelvic pain. Clin Obstet Gynecol 1990;33:196–204.

    Article  PubMed  CAS  Google Scholar 

  35. Flandry F, Hunt J, Terry G, et al. Analysis of subjective knee complaints using visual analog scales. Am J Sports Med 1991;19:112–118.

    Article  PubMed  CAS  Google Scholar 

  36. Jensen M, Karoly P, Braver S. The measurement of clinical pain intensity: a comparison of six methods. Pain 1986;27:117–126.

    Article  PubMed  CAS  Google Scholar 

  37. Tait R, Pollard C, Margolis R, et al. The Pain Disability Index: psychometric and validity data. Arch Phys Med Rehabil 1987;68:438–441.

    PubMed  CAS  Google Scholar 

  38. Wilkie D, Savedra M, Holzerner W, et al. Use of the McGill pain questionnaire to measure pain: a metaanalysis. Nurs Res 1990;39:36–41.

    Article  PubMed  CAS  Google Scholar 

  39. Koninckx P, Meuleman C, Demeyere S, et al. Suggestive evidence that pelvic endometriosis is a progressive disease, whereas deeply infiltrating endometriosis is associated with pelvic pain. Fertil Steril 1991;55:759–765.

    PubMed  CAS  Google Scholar 

  40. Martin D, Hubert G, Vander Zwaag R, et al. Depth of infiltration of endometriosis. J Gynecol Surg 1989;5:55.

    Article  Google Scholar 

  41. Cornillie F, Oosterlynck D, Lauweryns J, et al. Deeply infiltrating pelvic endometriosis: histology and clinical significance. Fertil Steril 1990;53:978–983.

    PubMed  CAS  Google Scholar 

  42. Halme J, Becker S, Wing R. Accentuated cyclic activation of peritoneal macrophages in patients with endometriosis. Am J Obstet Gynecol 1983;148:85–90.

    Google Scholar 

  43. Piper P. Pharmacology of leukotriene. Br Med Bull 1983; 39:255.

    PubMed  CAS  Google Scholar 

  44. Sturgis S, Call B. Endometriosis peritonei. Relation of pain to functional activity. Amer J of Obstet Gynecol 1954;68:1421–1431.

    CAS  Google Scholar 

  45. Droegemueller W, Herbst A, Mishell D, et al. Comprehensive Gynecology. Missouri: The C.V. Mosby Company, 1987, 1149.

    Google Scholar 

  46. Nesbitt R, Rizk P. Uterosacral ligament syndrome. Obstet Gynecol 1971;37:730–733.

    PubMed  Google Scholar 

  47. Redwine D, Sharp D. Endometriosis of the obturator nerve. A case report. J Reprod Med 1990;35:434–435.

    PubMed  CAS  Google Scholar 

  48. Badaway S, Marshall L, Gabal A, et al. The concentration of 13, 14-dihydro-15-keto-prostaglandin F2alpha and prostaglandin E2 in peritoneal fluid of infertile patients with and without endometriosis. Fertil Steril 1982;38:166–170.

    Google Scholar 

  49. Dawood M, Khan-Dawood F, Wilson L. Peritoneal fluid prostaglandins and prostanoids in women with endometriosis, chronic pelvic inflammatory disease, and pelvic pain. Am J Obstet Gynecol 1984;148:391–395.

    PubMed  CAS  Google Scholar 

  50. Drake T, O’Brien W, Ramwell P, et al. Peritoneal fluid thromoxane B2 and 6-keto prostaglandin Fla in endometriosis. Am J Obstet Gynecol 1981;140:401–422.

    PubMed  CAS  Google Scholar 

  51. Rapkin A, Bhattacherjee P. Peritoneal fluid eiscosanoids in chronic pelvic pain. Prostaglandins 1989;38:447–452.

    Article  PubMed  CAS  Google Scholar 

  52. Rock J, Dubin N, Ghodgaonkar R, et al. Cul-de-sac fluid in women with endometriosis: Fluid volume and prostanoid concentration during the proliferative phase of the cycle—days 8 to 12. Fertil Steril 1982;37:747–750.

    PubMed  CAS  Google Scholar 

  53. Schenken R, Asch R. Surgical induction of endometriosis in the rabbit: Effect on fertility and concentrations of peritoneal fluid prostaglandins. Fertil Steril 1980;34:581–587.

    PubMed  CAS  Google Scholar 

  54. Ylikorkala O, Vlinikka L. Prostaglandins and endometriosis. Acta Obstet Gynecol Scand 1983;113(Suppl): 105–107.

    Article  CAS  Google Scholar 

  55. Ferreira S, Nakamura M, Salete De Abreu Castro M. The hyperalgesic effects of prostacyclin and prostaglandin E2. Prostaglandins 1978;16:31–37.

    Article  PubMed  CAS  Google Scholar 

  56. Bray M. The pharmacology and pathophysiology of leukotriene B4. Br Med Bull 1983;39:249.

    PubMed  CAS  Google Scholar 

  57. Vernon M. Experimental endometriosis in laboratory animals as a research model. Prog Clin Biol Res 1990;323: 49–60.

    PubMed  CAS  Google Scholar 

  58. Vernon M, Wilson E. Studies on the surgical induction of endometriosis in the rat. Fertil Steril 1985;44:684–694.

    PubMed  CAS  Google Scholar 

  59. Vernon M, Beard J, Graves K, et al. Classification of endometriotic implants by morphologic appearance and capacity to synthesize prostaglandin F. Fertil Steril 1986; 46.

    Google Scholar 

  60. Harrop-Griffiths J, Katon W, Walker E, et al. The association between chronic pelvic pain, psychiatric diagnoses, and childhood sexual abuse. Obstet Gynecol 1988;71: 589–594.

    PubMed  CAS  Google Scholar 

  61. Rapkin A, Karnes L, Darke L, et al. History of physical and sexual abuse on women with chronic pelvic pain. Obstet Gynecol 1990;76:92–96.

    PubMed  CAS  Google Scholar 

  62. Rapkin A, Karnes L. The pain management approach to chronic pelvic pain. J Reprod Med 1987;32:323–327.

    PubMed  CAS  Google Scholar 

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Authors
  1. Alan B. Copperman
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  2. David Olive
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Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynecology, Mercer University School of Medicine, Macon, GA, 31207, USA

    Camran R. Nezhat M.D. , Farr R. Nezhat M.D.  & Ceana H. Nezhat M.D. ,  & 

  2. Department of Obstetrics and Gynecology, Department of Surgery, Stanford University School of Medicine, Stanford, CA, 94305, USA

    Camran R. Nezhat M.D. , Farr R. Nezhat M.D.  & Ceana H. Nezhat M.D. ,  & 

  3. Center for Special Pelvic Surgery, Atlanta, GA, 30342, USA

    Camran R. Nezhat M.D. , Farr R. Nezhat M.D.  & Ceana H. Nezhat M.D. ,  & 

  4. Center for Special Pelvic Surgery, Palo Alto, CA, 94304, USA

    Camran R. Nezhat M.D. , Farr R. Nezhat M.D.  & Ceana H. Nezhat M.D. ,  & 

  5. Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC, 27514, USA

    Gary S. Berger M.D.

  6. Department of Maternal and Child Health, University of North Carolina School of Public Health, Chapel Hill, NC, 27514, USA

    Gary S. Berger M.D.

  7. Chapel Hill Fertility Center, Chapel Hill, NC, 27514, USA

    Gary S. Berger M.D.

  8. Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, 77054, USA

    Veasy C. Buttram Jr. M.D.

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© 1995 Springer-Verlag New York, Inc.

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Copperman, A.B., Olive, D. (1995). Pathogenesis of Pelvic Pain in Endometriosis. In: Nezhat, C.R., Berger, G.S., Nezhat, F.R., Buttram, V.C., Nezhat, C.H. (eds) Endometriosis. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8404-5_5

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  • DOI: https://doi.org/10.1007/978-1-4613-8404-5_5

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-8406-9

  • Online ISBN: 978-1-4613-8404-5

  • eBook Packages: Springer Book Archive

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