Abstract
The normal physiological pattern of TSH secretion is characterized by circadian variation. After its nadir in the late afternoon, the serum TSH concentration rises to a peak around midnight, remains on a plateau for several hours, and then begins its decline. The rise from afternoon nadir to nighttime peak is called the nocturnal TSH surge; it is a hallmark of the circadian variation. Not only is the thyroid gland exposed to the highest concentrations of TSH at night, the thyroid gland is most active in releasing thyroidal iodine at night (1). Thus, the thyroid gland receives the preponderance of its trophic support from TSH during the night, subsequent to the nocturnal surge of TSH.
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© 1994 Springer-Verlag New York, Inc.
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Manasco, P.K., Blithe, D.L., Rose, S.R., Gelato, M.C., Magner, J.A., Nisula, B.C. (1994). Thyrotropin Abnormalities in Central Hypothyroidism. In: Lustbader, J.W., Puett, D., Ruddon, R.W. (eds) Glycoprotein Hormones. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8386-4_24
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DOI: https://doi.org/10.1007/978-1-4613-8386-4_24
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