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Receptor Binding Regions of hLH and hCGβ-Subunit: Structural and Functional Properties

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Glycoprotein Hormones

Part of the book series: Serono Symposia USA ((SERONOSYMP))

Abstract

For the study of structure-activity relations, we encounter in the glycoprotein hormones a group of molecules with characteristics of both a typical peptide hormone and a larger globular protein. As noted by Dyson and Wright (1), the active conformation of a small hormone or bioactive peptide may be imposed predominantly by the shape of the receptor, while regions of interest within a protein are inevitably involved in interactions within the molecule itself. In the absence of a detailed three-dimensional structure, the extent and nature of these influences within the glycoprotein hormone molecule remain largely uncharted. They must, however, be considered an important factor in the alignment and relative contributions of the multiple receptor binding sites revealed in all four glycoprotein hormones by assays of individual synthetic peptides (2–8).

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Authors
  1. Henry T. Keutmann
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Editors and Affiliations

  1. Irving Center for Clinical Research Columbia University College of Physicians and Surgeons, 10032, New York, NY, USA

    Joyce W. Lustbader Ph.D.

  2. Department of Biochemistry, University of Georgia, 30602, Athens, GA, USA

    David Puett Ph.D.

  3. Eppley Institute for Research, University of Nebraska Medical Center, 68198, Omaha, NE, USA

    Raymond W. Ruddon M.D., Ph.D.

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© 1994 Springer-Verlag New York, Inc.

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Keutmann, H.T. (1994). Receptor Binding Regions of hLH and hCGβ-Subunit: Structural and Functional Properties. In: Lustbader, J.W., Puett, D., Ruddon, R.W. (eds) Glycoprotein Hormones. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8386-4_10

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  • DOI: https://doi.org/10.1007/978-1-4613-8386-4_10

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-8388-8

  • Online ISBN: 978-1-4613-8386-4

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