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Role of Growth Hormone and Insulin-Like Growth Factor I in Immunoregulation

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Growth Hormone II

Part of the book series: Serono Symposia USA Norwell, Massachusetts ((SERONOSYMP))

Abstract

It has long been recognized that the steroidal, adrenal-derived glucocorticoid hormones have potent anti-inflammatory properties and suppress effector functions of both T lymphocytes and macrophages. Until recently, the idea that protein hormones from the adenohypophysis other than adrenocorticotropic hormone (ACTH) could play a role in immunoregulation was little more than a curiosity. Instead, the most likely candidates for soluble communication molecules that regulate the immune response were a group of molecules synthesized primarily by leukocytes and given the generic name of interleukins. Interleukins are proteins that are synthesized and secreted by either resting or activated leukocytes and deliver signals to other cells that are either necessary for or amplify some activity of another type of leukocyte. Because these proteins were originally thought to serve as communication molecules between leukocytes, they were named interleukins. At least twelve of these interleukins have now been identified in leukocytes, their genes have been cloned, and the recombinant proteins have been expressed in bacteria or yeast. This list of interleukins is rapidly growing. However, as discussed below, it is becoming increasingly difficult to distinguish between an interleukin (e.g., IL-1) and a hormone (e.g., GH).

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Authors
  1. Keith W. Kelley
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  2. Sean Arkins
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  3. Yong Ming Li
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Editors and Affiliations

  1. Pediatric Endocrinology, All Children’s Hospital, St. Petersburg, FL, 33701, USA

    Barry B. Bercu M.D.  & Richard F. Walker Ph.D.  & 

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Kelley, K.W., Arkins, S., Li, Y.M. (1994). Role of Growth Hormone and Insulin-Like Growth Factor I in Immunoregulation. In: Bercu, B.B., Walker, R.F. (eds) Growth Hormone II. Serono Symposia USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8372-7_7

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  • DOI: https://doi.org/10.1007/978-1-4613-8372-7_7

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-8374-1

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