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Regulation of Growth Hormone Output: The GRF Signal

  • Conference paper
Growth Hormone II

Part of the book series: Serono Symposia USA Norwell, Massachusetts ((SERONOSYMP))

Abstract

Like most anterior pituitary hormones, growth hormone (GH) is secreted into the bloodstream in a highly episodic manner. In recent years, it has become clear that both the amount of GH and the pattern in which it is secreted are important in determining its biological effects. The pattern of GH release is in turn governed primarily by output of hypothalamic hypophysiotropic peptides, somatostatin (SS) and GH releasing factor (GRF), integrated with input from peripheral endocrine (adrenal, thyroid, gonadal, and pancreatic hormones) and nutritional factors at both hypothalamic and pituitary levels. Furthermore, GH itself and the IGF-I that it generates both can feed back to inhibit production and/or release of GH into peripheral blood.

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Authors
  1. I. C. A. F. Robinson
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Editors and Affiliations

  1. Pediatric Endocrinology, All Children’s Hospital, St. Petersburg, FL, 33701, USA

    Barry B. Bercu M.D.  & Richard F. Walker Ph.D.  & 

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Robinson, I.C.A.F. (1994). Regulation of Growth Hormone Output: The GRF Signal. In: Bercu, B.B., Walker, R.F. (eds) Growth Hormone II. Serono Symposia USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8372-7_4

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  • DOI: https://doi.org/10.1007/978-1-4613-8372-7_4

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-8374-1

  • Online ISBN: 978-1-4613-8372-7

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