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Biochemical and Functional Properties of Somatostatin Receptors

  • Conference paper
Growth Hormone II

Part of the book series: Serono Symposia USA Norwell, Massachusetts ((SERONOSYMP))

  • 66 Accesses

Abstract

The tetradecapeptide somatostatin (SRIF) exerts diverse biological actions in the endocrine and nervous systems (1, 2). It is the major physiological inhibitor of growth hormone secretion from the anterior pituitary and insulin and glucagon release from the pancreatic islets and also regulates gastric acid secretion from the gut (3–6). SRIF is also expressed in extrahypothalamic locations in the brain, where it has a role in controlling cognitive functions (7, 8). Furthermore, in the striatum, where it has been implicated in modulating locomotor activity (9, 10), SRIF is a major stimulant of dopamine release from nigrostriatal neurons and may interact with dopamine in modulating basal ganglia functions (11).

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Authors
  1. Terry Reisine
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  2. Karen Raynor
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  3. Haeyoung Kong
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  4. Susan F. Law
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  5. Magali Theveniau
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  6. Melanie Tallent
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  7. Stephanie Rens-Domiano
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  8. John Hines
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  9. Kazuki Yasuda
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  10. Graeme I. Bell
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Editor information

Editors and Affiliations

  1. Pediatric Endocrinology, All Children’s Hospital, St. Petersburg, FL, 33701, USA

    Barry B. Bercu M.D.  & Richard F. Walker Ph.D.  & 

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© 1994 Springer-Verlag New York, Inc.

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Reisine, T. et al. (1994). Biochemical and Functional Properties of Somatostatin Receptors. In: Bercu, B.B., Walker, R.F. (eds) Growth Hormone II. Serono Symposia USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8372-7_3

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  • DOI: https://doi.org/10.1007/978-1-4613-8372-7_3

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-8374-1

  • Online ISBN: 978-1-4613-8372-7

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