Biochemical and Functional Properties of Somatostatin Receptors

  • Terry Reisine
  • Karen Raynor
  • Haeyoung Kong
  • Susan F. Law
  • Magali Theveniau
  • Melanie Tallent
  • Stephanie Rens-Domiano
  • John Hines
  • Kazuki Yasuda
  • Graeme I. Bell
Conference paper
Part of the Serono Symposia USA Norwell, Massachusetts book series (SERONOSYMP)

Abstract

The tetradecapeptide somatostatin (SRIF) exerts diverse biological actions in the endocrine and nervous systems (1, 2). It is the major physiological inhibitor of growth hormone secretion from the anterior pituitary and insulin and glucagon release from the pancreatic islets and also regulates gastric acid secretion from the gut (3–6). SRIF is also expressed in extrahypothalamic locations in the brain, where it has a role in controlling cognitive functions (7, 8). Furthermore, in the striatum, where it has been implicated in modulating locomotor activity (9, 10), SRIF is a major stimulant of dopamine release from nigrostriatal neurons and may interact with dopamine in modulating basal ganglia functions (11).

Keywords

Sugar Carbohydrate Dopamine Polypeptide Glutamine 

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Copyright information

© Springer-Verlag New York, Inc. 1994

Authors and Affiliations

  • Terry Reisine
  • Karen Raynor
  • Haeyoung Kong
  • Susan F. Law
  • Magali Theveniau
  • Melanie Tallent
  • Stephanie Rens-Domiano
  • John Hines
  • Kazuki Yasuda
  • Graeme I. Bell

There are no affiliations available

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