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Changes in Growth Hormone Secretory Dynamics in Chronic Renal Failure and in Adaptation to Moderately High Altitude Living

  • Conference paper
Growth Hormone II

Part of the book series: Serono Symposia USA Norwell, Massachusetts ((SERONOSYMP))

  • 66 Accesses

Abstract

Several studies have shown abnormalities in the hypothalamic-hypophyseal axes in patients on chronic hemodialysis: blunted thyroid stimulating hormone (TSH) response to exogenous thyrotropin releasing hormone (TRH) (1–4), hyperprolactinemia (5, 6), elevated basal levels of luteinizing hormone (LH) (7–9), attenuated gonadotropin secretory response to exogenous gonadotropin releasing hormone (GnRH) (9), lack of adrenocorticotropin (ACTH) release in response to insulin-induced hypoglycemia (10), and blunted ACTH response following exogenous corticotropin releasing hormone (CRH) administration (11). The secretory pattern of growth hormone (GH) is also abnormal. Hypoglycemia fails to release GH (12) and hyperglycemia produces a paradoxical increase in GH (12). Growth hormone releasing hormone (GHRH) produces an exaggerated release of pituitary GH in uremic children (13) and adults (14). These observations suggest that there is a differential hypothalamo-hypophyseal regulation, possibly due to alterations in hypothalamic neurotransmitters, which can affect secretion of the hypothalamic hormones.

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Authors
  1. German Ramirez
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Editors and Affiliations

  1. Pediatric Endocrinology, All Children’s Hospital, St. Petersburg, FL, 33701, USA

    Barry B. Bercu M.D.  & Richard F. Walker Ph.D.  & 

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© 1994 Springer-Verlag New York, Inc.

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Ramirez, G. (1994). Changes in Growth Hormone Secretory Dynamics in Chronic Renal Failure and in Adaptation to Moderately High Altitude Living. In: Bercu, B.B., Walker, R.F. (eds) Growth Hormone II. Serono Symposia USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8372-7_14

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  • DOI: https://doi.org/10.1007/978-1-4613-8372-7_14

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-8374-1

  • Online ISBN: 978-1-4613-8372-7

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