Effects of Growth Hormone Releasing Peptides on Stimulated Growth Hormone Secretion in Old Rats

  • Richard F. Walker
  • Sei-Won Yang
  • Ryuji Masuda
  • Cheng-Shih Hu
  • Barry B. Bercu
Conference paper
Part of the Serono Symposia USA Norwell, Massachusetts book series (SERONOSYMP)

Abstract

Degenerative changes in body composition characterized by reduced muscle and bone mass decrease physical performance in the elderly. These decremental somatic changes correlate with reduced serum growth hormone (GH) concentrations. Limited availability of cadaver-derived hormone before the advent of recombinant gene technology precluded testing the functional relationship between GH deficiency and senescence. However, when bioengineered GH became available for experimentation, its administration to old men significantly increased serum IGF-I concentrations, urinary nitrogen retention, body weight gain, lean body mass, bone density, renal function, and improved quality of life (1–3). Thus, aberrant patterns of spontaneous GH secretion and low serum GH concentrations during aging (4–7) did not necessarily represent loss of GH efficacy. Furthermore, the experimental observations suggested a causal relationship between anatomical senescence and GH insufficiency (3, 4, 8, 9).

Keywords

Cholesterol Dopamine Amide Adenoma Morphine 

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Copyright information

© Springer-Verlag New York, Inc. 1994

Authors and Affiliations

  • Richard F. Walker
  • Sei-Won Yang
  • Ryuji Masuda
  • Cheng-Shih Hu
  • Barry B. Bercu

There are no affiliations available

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