Abstract
In 1990 the authors described the effects of human growth hormone (hGH) in 12 hyposomatomedinemic healthy men over 60 years of age (1). A significant increase in lean body mass and a decrease in adipose tissue mass were observed during a 6-month treatment period. The hGH doses were chosen in order to elevate the plasma level of insulin-like growth factor I (IGF-I, also termed somatomedin C) to a youthful range of 0.5–1.5 units/ml. Early adverse side effects were not observed. The present chapter extends the earlier report by describing a larger group of hyposomatomedinemic men over 60 years old, initially numbering 42, who were treated for up to 12 months. Complications of hGH treatment were encountered and a relation to the plasma level of IGF-I was identified.
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References
Rudman D, Feller AG, Nagraj HS, et al. Effects of human growth hormone in men over sixty years old. N Engl J Med 1990;323:1–6.
Furlanetto RW, Underwood LE, Van Wyk JJ, D’Ercole AJ. Estimation of somatomedin C levels in normals and patients with pituitary disease by radioimmunoassay. J Clin Invest 1977;60:648–57.
Gellman H, Gelberman RM, Tan AM, Botte MJ. Carpal tunnel syndrome: an evaluation of the provocative diagnostic tests. J Bone Joint Surg 1986; 68A:735–7.
Stevens JC. AAEE minimonograph #26. The electrodiagnosis of carpal tunnel syndrome. Muscle Nerve 1987;10:99–113.
Daughady WH, Mariz IK, Blethen SL. Inhibition of access of bound somatomedin to membrane receptor and immunobinding sites: a comparison of radioreceptor and radioimmunoassay of somatomedin in native and aeid-ethanol-extracted serum. J Clin Endocrinol Metab. 1980;51:781–8.
Flynn MA, Nolph GB, Baker AS, Martin WM, Krause G. Total body potassium in aging humans: a longitudinal study. Am J Clin Nutr 1989;50:713–7.
Mazess RB, Barden HS, Bisek JP, Hanson J. Dual energy x-ray absorptiometry for total body and regional bone mineral and soft tissue composition. Am J Clin Nutr 1990;51:1106–12.
National Diabetes Data Group. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 1979;28:1039–57.
Clemmons DR, Van Wyk JJ, Ridgway EC, Kliman B, Kjellberg RN, Underwood LE. Evaluation of acromegaly by radioimmunoassay of somatomedin-C. N Engl J Med 1979;301:1138–42.
O’Duffy JD, Randall RV, MacCarty CS. Median neuropathy (carpal tunnel syndrome) in acromegaly. A sign of endocrine overactivity. Ann Intern Med 1973;78:379–83.
Jadresic A, Banks LM, Child DF, et al. The acromegaly syndrome. Q J Med, New Series, 1982;202:189–204.
Rudman D, Nagraj HS, Mattson DE, et al. Hyposomatomedinemia in the men of a Veterans Administration nursing home: prevalence and correlates. Gerontology 1987;33:307–14.
Donahue LR, Hunter SJ, Sherblom AP, Rosen C. Age-related changes in serum insulin-like growth factor-binding proteins in women. J Clin Endocrinol Metab 1990;71:575–9.
Unterman T, Dempsey S, Jentel JJ, Oehler DT, Rudman D. Alterations in insulin-like growth factor binding proteins in aging men. Clin Res 1992;40:395A.
Spinner RJ, Bachman JW, Amadio PC. The many faces of carpal tunnel syndrome. Mayo Clin Proc 1989;64:829–36.
Davidson MB. The effect of aging on carbohydrate metabolism: a review of the English literature and a practical approach to the diagnosis of diabetes mellitus in the elderly. Metabolism 1979;28:688–705.
Blackman MR, Kowatch MA, Wehmann RE, Harman SM. Basal serum prolactin levels and prolactin responses to constant infusions of thyrotropin releasing hormone in healthy aging men. J Gerontol 1986;41:699–705.
Carlson HE. Gynecomastia: pathogenesis and therapy. Endocrinologist 1991;1:337–42.
Christiansen JS, Jorgensen JO, Pedersen SA, Miller J, Jorgensen J, Skakkeboek NE. Effects of growth hormone on body composition in adults. Horm Res 1990;4:61–4.
Aloia JF, Zanzi I, Ellis K, et al. Effects of growth hormone in osteoporosis. J Clin Endocrinol Metab 1976;43:992–9.
Salomon F, Cuneo RC, Hesp R, Sonksen PH. The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N Engl J Med 1989;321:1797–803.
Nabarro JDN. Acromegaly. Clin Endocrinol (Oxf) 1987;26:481–512.
Cullen KJ, Yee D, Sly WS, et al. Insulin-like growth factor receptor expression and function in human breast cancer. Cancer Res 1990;50:48–53.
Daughaday WH. The possible autocrine/paracrine and endocrine roles of insulin-like growth factors of human tumors. Endocrinology 1990;127:1–4.
Essat S, Melmed S. Are patients with acromegaly at increased risk for neoplasia? J Clin Endocrinol Metab 1991;72:245–9.
Nagraj HS, Gergans GA, Mattson DE, Rudman IW, Rudman D. Osteopenia in the men of a Veterans Administration nursing home. Am J Clin Nutr 1990;51:100–6.
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Cohn, L., Feller, A.G., Rudman, I.W., Rudman, D. (1994). Further Observations on the Effects of Human Growth Hormone in Elderly Hyposomatomedinemic Men. In: Bercu, B.B., Walker, R.F. (eds) Growth Hormone II. Serono Symposia USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8372-7_10
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DOI: https://doi.org/10.1007/978-1-4613-8372-7_10
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