A Role for Neurotrophic Factors in Ovarian Development

  • Sergio R. Ojeda
  • Gregory A. Dissen
  • Sasha Malamed
  • Anne N. Hirshfield
Part of the Proceedings in the Serono Symposia, USA Series book series (SERONOSYMP)


In recent years it has become increasingly clear that several growth factors involved in the differentiation of neural cells are similar or identical to those that control the developmental fate of nonneural cells. One of the most striking examples of this regulatory linkage is provided by stem cell factor (SCF), the gene product of the mouse steel (Sl) locus that is required for the differentiation and proliferation of three entirely different cell lineages: neural crest-derived melanocytes, hematopoietic cells, and gonadal germ cells (reviewed in 1). Although SCF induces neither proliferation nor migration of gonadal germ cells, it appears to be essential for their survival (2). Thus, mutations at either the Sl locus (that disrupt the synthesis of SCF) or at the white spotting (W) locus that encodes the SCF receptor (1) severely deplete the number of germ cells able to colonize the genital ridge (2, 3). Strong evidence exists that the SCF receptor is the product of the c-kit protooncogene (4), a transmembrane tyrosine kinase receptor encoded by W (5).


Nerve Growth Factor Granulosa Cell Stem Cell Factor Ovarian Development Primordial Follicle 
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Copyright information

© Springer-Verlag New York, Inc. 1993

Authors and Affiliations

  • Sergio R. Ojeda
  • Gregory A. Dissen
  • Sasha Malamed
  • Anne N. Hirshfield

There are no affiliations available

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