Clinical Trials of Ticlopidine in Patients with Coronary Artery Disease

  • Francesco Balsano
  • Francesco Violi


Acute coronary syndromes, including myocardial infarction, unstable angina, and early complications occurring after aortocoronary bypass or angioplasty, are well recognized conditions in which in situ activation of platelets and the coagulation cascade play a pivotal role. Therefore, anticoagulant or antiplatelet drugs have been employed to reduce vascular thrombosis and minimize clinical complications secondary to vascular occlusion. In regard to antiplatelet drugs, many studies have been performed with aspirin, an inhibitor of the cyclooxygenase enzyme that prevents formation of thromboxane TXA2, a potent aggregating and vasoconstrictor agent.


Unstable Angina Vein Graft Antiplatelet Drug Nonfatal Myocardial Infarction Vascular Death 
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© Springer-Verlag New York Inc. 1993

Authors and Affiliations

  • Francesco Balsano
  • Francesco Violi

There are no affiliations available

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