Hyperprolactinemia and Polycystic Ovarian Disease
Hyperprolactinemia is a frequent concomitant of infertility, hypogonadism, and may be found in 27% of patients with PCOD. The isolation of prolactin and the development of a sensitive radioimmunoassay for its measurement has enabled the clinician to identify those clinical states that may be associated with hyperprolactinemia, and offers an option of medical treatment which may be useful in the treatment of the underlying pathological disturbance. It must be stressed that hyperprolactinemia is the most common hypothalamic-pituitary disorder in the human and an understanding of the pathophysiological effects of hyperprolactinemia is clearly important in the evaluation and management of such patients who may present with galactorrhea and/or menstrual abnormalities. Excellent re-views of PRL secretion and physiology have been reported (27,240,275,415,967).
KeywordsDopamine Cortisol Testosterone Estradiol Haloperidol
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