Infertility pp 143-160 | Cite as

Uterine Function and Abnormalities Causing Infertility

  • G. William Bates
  • Winfred L. Wiser
Part of the Clinical Perspectives in Obstetrics and Gynecology book series (CPOG)

Abstract

The uterus fulfills a number of roles in reproduction. At the cervix, the uterus traps seminal fluid in the cervical secreations where spermatozoa are either stored in crypts for later use or immediately swim cephalad into the fallopian tubes. With ejaculation of semen into the posterior fornix of the vagina, the uterus begins a series of rhythmic contractions that aid the transport of spermatozoa to the fallopian tubes. This process is mediated by prostaglandins contained within the seminal fluid (1) and sperm can be found in the human fallopian tubes as early as 5 minutes after insemination (2).

Keywords

Estrogen Mold Tuberculosis Prostaglandin Tamoxifen 

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References

  1. 1.
    Coutinho EM, Maia HS. The contractile response of the human uterus, fallopian tubes, and ovary to prostaglandins in vivo. Fertil Steril 1971; 22: 539–543.PubMedGoogle Scholar
  2. 2.
    Settlage DSF, Motoshima M, Tredway DS. Sperm transport from the external cervical os to the fallopian tubes in women: a time and quantitation study. Fertil Steril 1973; 24: 655–661.PubMedGoogle Scholar
  3. 3.
    Noyes RW, Hertig AT, Rock J. Dating the endometrial biopsy. Fertil Steril 1950; 1: 3–25.Google Scholar
  4. 4.
    Ramsey EM. Embryology and developmental defects of the female genital tract. In: Danforth DN, ed. Obstetrics and gynecology. Philadelphia: Harper and Row, 1982: 112–126.Google Scholar
  5. 5.
    Griffin JE, Edwards C, Madden JD, Harrod MJ, Wilson JD. Congenital absence of the vagina: the Mayer-Rokitansky-Kuster-Hauser syndrome. Ann Intern Med 1976; 85: 244–236.Google Scholar
  6. 6.
    Evans TN, Poland ML, Boving RL. Vaginal malformations. Am J Obstet Gynecol 1981; 141: 910–920.PubMedGoogle Scholar
  7. 7.
    Jost A. Problems of fetal endocrinology: the gonadal and hypophyseal hormones. Recent Prog Horm Res 1953; 8: 379–418.Google Scholar
  8. 8.
    Serra GB, Perez-Palacios G, J a f f e RB. De novo testosterone biosynthesis in human fetal testes.J Clin Endocrinol Metab 1970; 30: 128–130.Google Scholar
  9. 9.
    Wilson JD. Recent studies on the mechanism of action of testosterone. N Engl J Med 1972; 287: 1284–1292.PubMedCrossRefGoogle Scholar
  10. 10.
    Herbst AL, Ulfelder H, Pockanger DC. Adenocarcinoma of the vagina: association of maternal stilbestrol therapy with tumor appearance in young women. N Engl J Med 1971; 284: 878–881.Google Scholar
  11. 11.
    Gill WB, Schumacher FB, Bibbo M. Structural and functional abnormalities in the sex organs of male offspring of mothers treated with diethylstilbestrol (DES). J Reprod MedGoogle Scholar
  12. 12.
    Kaufman RH, Binder GL, Gray PM Jr, Adam E. Upper genital tract changes associated with exposure in utero to diethylstilbestrol. Am J Obstet Gynecol 1977; 128: 51–59.PubMedGoogle Scholar
  13. 13.
    Bryan AL, Nigro JA, Counseller VS. One hundred cases of congenital absence of the vagina. Surg Gynecol Obstet 1949; 88: 79–86.PubMedGoogle Scholar
  14. 14.
    Jeffcoate TNA. Advancement of the uper vagina in the treatment of hematocolpos and hematometra caused by vaginal aplasia. Pregnancy following the construction of an artificial vagina. J Obstet Gynaecol Br Commonw 1969; 76: 961–968.CrossRefGoogle Scholar
  15. 15.
    Musset R. Aplasia vaginale avec uterus fonctionnel resultats operatoires et commentaires: a propos de 10 observations. J Gynecol Obstet Biol Reprod (Paris) 1978; 7: 316–333.Google Scholar
  16. 16.
    Frank RT. The formation of an artificial vagina without operation. Am J Obstet Gynecol 1938; 35: 1053–1055.Google Scholar
  17. 17.
    Mclndoe AH, Banister JB. An operation for the cure of congenital absence of the vagina. J Obstet Gynaecol Br Emp 1938; 45: 490–494.CrossRefGoogle Scholar
  18. 18.
    Wiser WL, Bates GW. Management of vaginal agenesis: a report of 92 cases. Surg Gynecol Obstet (In press, February, 1984).Google Scholar
  19. 19.
    Hecker BR, McGuire LS. Psychosocial function in women treated for vaginal agenesis. Am J Obstet Gynecol 1977; 129: 543–547.PubMedGoogle Scholar
  20. 20.
    Ingram JM. The bicycle seat stool in the treatment of vaginal agenesis and stenosis: a preliminary report. Am J Obstet Gynecol 1981; 140: 867–873.PubMedGoogle Scholar
  21. 21.
    Niver DH, Barrett G, Jewelewicz R. Congenital 8. Uterine Function and Abnormalities Causing Infertility 159 atresia of the uterine cervix and vagina: three cases. Fertil Steril 1980; 33: 25–29.PubMedGoogle Scholar
  22. 22.
    Geary WL, Weed JC. Congenital atresia of the uterine cervix. Obstet Gynecol 1973; 42: 213–217.PubMedGoogle Scholar
  23. 23.
    Rock J A, Jones HW Jr. The double uterus associated with an obstructed hemivagina and ipsilateral renal agenesis. Am J Obstet Gynecol 1980; 138: 339–342.PubMedGoogle Scholar
  24. 24.
    Green LK, Harris RE. Uterine anomalies. Frequency of diagnosis and associated obstetric complications. Obstet Gynecol 1976; 46: 427–429.Google Scholar
  25. 25.
    Musich Jr, Behrman SJ. Obstetric outcome before and after metroplasty in women with uterine anomalies. Obstet Gynecol 1978; 52: 63–66.Google Scholar
  26. 26.
    Rock JA, Jones HW Jr. The clinical management of the double uterus. Fertil Steril 1977; 28: 798–806.PubMedGoogle Scholar
  27. 27.
    Jones HW Jr. Reproductive impairment and the malformed uterus. Fertil Steril 1981; 36: 137–148.PubMedGoogle Scholar
  28. 28.
    Craig CJT. Congenital abnormalities of the uterus and foetal wastage. S Afr Med J 1973; 47: 2000–2005.PubMedGoogle Scholar
  29. 29.
    Strassmann EO. Fertility and unification of the double uterus. Fertil Steril 1966; 17: 165–176.PubMedGoogle Scholar
  30. 30.
    Capraro KJ, Chuang JT, Randall CL. Improved fetal salvage after metroplasty. Obstet Gynecol 1968; 31: 97–103.PubMedCrossRefGoogle Scholar
  31. 31.
    Buttram VC, Zanotti L, Acosta AA, Vanderheyden JS, Besch PK, Franklin RR. Surgical correction of the septate uterus. Fertil Steril 1974; 25: 373–379.PubMedGoogle Scholar
  32. 32.
    Jones HW Jr, Wheeless CR. Salvage of the reproductive potential of women with anomalous development of the mullerian ducts, 1868–1968-2068. Am J Obstet Gynecol 1969; 104: 348–364.PubMedGoogle Scholar
  33. 33.
    Strassmann P. Die operative Vereinizing eines doppelten uterus. Zentralbl Gynaekol 1907; 43: 1322.Google Scholar
  34. 34.
    Tompkins P. Comments on the bicornuate uterus and twinning. Surg Clin North Am 1962; 42: 1049–1062.PubMedGoogle Scholar
  35. 35.
    Jones HW Jr, Jones GES. Double uterus as an etiological factor of repeated abortion, indication for surgical repair. Am J Obstet Gynecol 1953; 65: 325–339.PubMedGoogle Scholar
  36. 36.
    Jones HW Jr, Rock J A. Anomalies of the mullerian ducts. In: Reparative and constructive surgery of the female generative tract. Baltimore: Williams Wilkins, 1982: 146–185.Google Scholar
  37. 37.
    Smith OW, Smith GV, Hurwitz D. Increased execretion of pregnanediol in pregnancy from iethylstilbestrol with special reference to late pregnancy accidents. Am J Obstet Gynecol 1946; 51: 411–415.PubMedGoogle Scholar
  38. 38.
    Dieckmann WJ, Davis ME, Rynkiewicz IM, Pottinger RE. Does the administration of diethylstilbestrol during pregnancy have therapeutic value? Am J Obstet Gynecol 1953: 66: 1062–1081.PubMedGoogle Scholar
  39. 39.
    Kaufman RH, Adam E, Binder GL, Gerthoffer E. Upper genital tract changes and pregnancy outcome in offspring exposed in utero to diethylstilbestrol. Am J Obstet Gynecol 1980; 137: 299–308.PubMedGoogle Scholar
  40. 40.
    Haney AF, Hammond CB, Soules MR, Creasman WT. Diethylstilbestrol-induced genitaltract abnormalities. Fertil Steril 1979; 31: 142–146.PubMedGoogle Scholar
  41. 41.
    Bibbo M, Gill WB, Azizi F, et al. Follow-up study of male and female offspring of DESexposed mothers. Obstet Gynecol 1977; 49: 1–8.PubMedGoogle Scholar
  42. 42.
    Barnes AB, Colton T, Gundersen J, et al. Fertility and outcome of pregnancy in women exposed in utero to diethylstilbestrol. N Engl J Med 1980; 302: 609–613.PubMedCrossRefGoogle Scholar
  43. 43.
    Berger MJ, Goldstein DP. Impaired reproductive performance in DES-exposed women. Obstet Gynecol 1980; 55: 25–27.PubMedGoogle Scholar
  44. 44.
    Goldstein DP. Incompetent cervix in offspring exposed to diethylstilbestrol in utero. Obstet Gynecol 1978; 52: 73S–75S.PubMedGoogle Scholar
  45. 45.
    Noller KL, Townsend DE, Kaufman RH. Genital findings, colposcopic evaluation, and current management of the diethylstilbestrol-exposed female. In: Herbert AL, Bern HA, eds. Developmental effects of diethylstilbestrol (DES) in pregnancy. New York: Thieme-Stratton, 1981: 81–102.Google Scholar
  46. 46.
    Buttram VC, Reiter RC. Uterine leiomyomata: etiology, symptomatology, and management. Fertil Steril 1981; 36: 433–445.PubMedGoogle Scholar
  47. 47.
    Ranney B, Frederick I. The occasional need for myomectomy. Obstet Gynecol 1979; 53: 437–441.PubMedGoogle Scholar
  48. 48.
    Malone LF, Ingersoll FM. Myomectomy in infertility. In: Behrman SJ, Kistner RW, eds. Progress in Infertility. Boston: Little, Brown 8c Co., 1975: 85–90.Google Scholar
  49. 49.
    Jones HW Jr, Rock JA. Surgery of the body of the uterus. In: Reparative and constructive surgery of the female generative tract. Baltimore: Williams Wilkins, 1983; 61–7l.Google Scholar
  50. 50.
    Wilson EA, Yang F, Rees ED. Estradiol and progesterone binding in uterine leiomyomata and in normal uterine tissues. Obstet Gynecol 1980; 55: 20–24.PubMedGoogle Scholar
  51. 51.
    Hunt JE, Wallach EE. Uterine factors in infertility an overview. Clin Obstet Gynecol 1974; 17: 44–64.PubMedCrossRefGoogle Scholar
  52. 52.
    Asherman JG. Traumatic intrauterine adhesions. J Obstet Gynaecol Br Empire 1950; 57: 892–896.CrossRefGoogle Scholar
  53. 53.
    Klein SM. Ashermans syndrome. In: Sciarra J, ed. Gynecology and obstetrics, Vol. 5, Chap. 24. Philadelphia: Harper 8c Row, 1982: 1–8.Google Scholar
  54. 54.
    Loures NC, Danezis JM, Potifix G. Use of intrauterine devices in the treatment of intrauterine adhesions. Fertil Steril 1968; 19: 509–528.Google Scholar
  55. 55.
    March CM, Israel R, March AD. Hysteroscopic management of intrauterine adhesions. Am J Obstet Gynecol 1978; 130: 653–657.PubMedGoogle Scholar
  56. 56.
    Sugimoto O. Diagnostic and therapeutic hysteroscopy for traumatic intrauterine adhesions. Am J Obstet Gynecol 1978; 131: 539–547.PubMedGoogle Scholar
  57. 57.
    Mishell DR, Moyer DL. Association of pelvic inflammatory disease with the intrauterine device. Clin Obstet Gynecol 1969; 12: 179–197.PubMedCrossRefGoogle Scholar
  58. 58.
    Schiffer MA, Elguezabal A, Sultana M, Allen AC. Actinomycosis infections associated with intrauterine contraceptive devices. Obstet Gynecol 1975; 45: 67–72.PubMedGoogle Scholar
  59. 59.
    Monif GRG. Infectious diseases in obstetrics and gynecology. Philadelphia: Harper 8c Row, 1982.Google Scholar
  60. 60.
    Mordh PA, Ripe T, Svensson L, Westrom L. Chlamydia trachomatis in patients with acute salpingitis. N Engl J Med 1977; 296: 1377–1379.CrossRefGoogle Scholar
  61. 61.
    Rozin S. Genital tuberculosis. In: Behrman SJ, Kistner RW, eds. Progress in infertility. Boston: Little, Brown 8c Co., 1975: 189–206.Google Scholar
  62. 62.
    Hafez ESE. Anatomy and physiology of he mammalian uterotubal junction. In: Greep RO, stwood EB, eds. Handbook of physiology, Vol 7. Washington, D.C.: American Physiological Society, 1973: 87–95.Google Scholar
  63. 63.
    Lisa JR, Giola JD, Rubin IC. Observations on the interstitial portion of the fallopian tube. Surg Gynecol Obstet 1954; 99: 159–169.Google Scholar
  64. 64.
    Ayres JWT. Hormonal therapy for tubal occlusion: danazol and tubal endometriosis. Fertil Steril 1982; 38: 748–750.Google Scholar
  65. 65.
    Ansari AH, Nagamani M. Foley catheter for salpingography, pneumography, tubal insufflation, and hydrotubation. Obstet Gynecol 1977; 50: 108–112.PubMedGoogle Scholar
  66. 66.
    Valle RF, Sciarra JJ. Current states of hysteroscopy in gynecologic practice. In: Wallach EE, Kempers RD, eds. Modern trends in infertility and conception control. Philadelphia: Harper 8c Row, 1982: 210–223.Google Scholar

Copyright information

© Springer-Verlag New York, Inc. 1984

Authors and Affiliations

  • G. William Bates
  • Winfred L. Wiser

There are no affiliations available

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