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Genetic Defects of the Complement Pathways: Relationship to HLA and Disease

  • Peter H. Schur

Abstract

There are known and theoretical defects in the immune response system which might make an individual susceptible to the development of nephritis. Certainly the various deficiencies of immunoglobulins, B and T lymphocytes are well known, and are clinically characterized by recurrent infections. They are not known to be associated with renal diseases, other than perhaps urinary tract infections. Increasing interest has focused lately on inherited, isolated deficiencies of components of the complement system. While first recognized in otherwise normal individuals (reviewed in Jersild et al., 1976; Carpenter et al., 1977; Schur, 1977, 1978; Agnello, 1978), there have recently been numerous reports of their association with disease.

Keywords

Major Histocompatibility Complex Complement Pathway Membranoproliferative Glomerulonephritis Hereditary Angioedema Complement Deficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag US 1983

Authors and Affiliations

  • Peter H. Schur
    • 1
  1. 1.Divison of Rheumatology and ImmunologyBrigham and Women’s Hospital, Harvard Medical SchoolBostonUSA

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