Central Noradrenergic Receptors: Localization, Function and Molecular Mechanisms

  • Floyd E. Bloom
  • Barry J. Hoffer
  • George R. Siggins

Abstract

Fluorescence histochemical data make it eminently clear that the catecholamine-containing neurons of the brain are restricted to a relatively small region of the pons and mesencephalon and yet send very discrete axonal tracts to spinal cord, diencephalon and cortices. In order to determine the effects of norepinephrine (NE) on postsynaptic neurons and the changes in these effects produced by drugs which influence behavior, the location and function of the presumed NE-mediated synapses must be determined for each of the regions receiving these fibers. Such data has now been accumulated in detail for the NE projection to the cerebellum (see below) and has been partially elucidated for several other regions. This paper will describe the methods now being used in our laboratory to determine the localization and function of NE-mediated synapses.

Keywords

Nicotinate Adenosine Serotonin Histamine Prostaglandin 

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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Floyd E. Bloom
    • 1
  • Barry J. Hoffer
    • 1
  • George R. Siggins
    • 1
  1. 1.Laboratory of Neuropharmacology, Division of Special Mental Health Research, National Institute of Mental HealthSt. Elizabeths HospitalUSA

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