Peptide Synthesis and the Specificity of Proteinases
It was my good fortune to share a laboratory with Leonidas Zervas at the Rockefeller Institute for Medical Research after he came there in 1934 to rejoin Max Bergmann. The year before, the Nazis had obliged Bergmann to resign as Director of the Kaiser Wilhelm Institute for Leather Research in Dresden; after finding a haven in New York, he secured the help of the Rockefeller Foundation in bringing Zervas to the United States. I cannot express adequately my gratitude to Professor Zervas for the instruction he gave me in the art of peptide synthesis during his 2-year stay in New York. This essay is not only an act of homage to a great chemist, but also an acknowledgment of the debt owed him by one of his students.
KeywordsTrypsin Oligosaccharide Benzyl Lysozyme Hydrolase
Unable to display preview. Download preview PDF.
- Bergmann, M., and Fruton, J. S.. 1937. On proteolytic enzymes. XIII. Synthetic substrates for chymotrypsin, J. Biol. Chem. 118: 405.Google Scholar
- Bergmann, M., Zervas, L., Fruton, J. S., Schneider, F., and Schleich, H., 1935, On proteolytic enzymes. V. On the specificity of dipeptidase, J. Biol. Chem. 109: 325.Google Scholar
- Bergmann, M., Zervas, L., and Fruton, J. S., 1936, On proteolytic enzymes. XI. The specificity of the enzyme papain peptidase I, J. Biol. Chem. 115: 593.Google Scholar
- Bergmann, M., Fruton. J. S., and Pollok, H.. 1939, The specificity of trypsin, J. Biol. Chem. 127: 643.Google Scholar
- Fruton, J. S., 1957, Enzymic hydrolysis and synthesis of peptide bonds, Harvey Lectures 51: 64.Google Scholar
- Fruton, J. S., 1971, Pepsin, in “The Enzymes.” 3rd ed., Vol. 3 (P. D. Boyer, ed.), p. 119, Academic Press, New York.Google Scholar
- Fruton, J. S., and Bergmann. M., 1939. The specificity of pepsin, J. Biol. Chem. 127: 627.Google Scholar