Use of Polymeric Reagents in the Synthesis of Linear and Cyclic Peptides

  • A. Patchornik
  • M. Fridkin
  • E. Katchalski

Abstract

New methods of peptide synthesis have yielded impressive successes in recent years in the preparation of many naturally occurring polypeptides. ACTH (Schwyzer and Sieber, 1963), glucagon (Wünsch, 1967), calcitonin (Sieber et al., 1968; Guttman et al., 1968), ferredoxin (Bayer et al., 1968), ribonuclease A (Denkewalter et al., 1969 ; Gutte and Merrifield, 1969), and human pituitary growth hormone (Li and Yamashiro, 1970) are representative of a large number of polypeptides which have been prepared chemically.

Keywords

Polypeptide Polystyrene Thiol Anhydride Benzyl 

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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • A. Patchornik
    • 1
  • M. Fridkin
    • 1
  • E. Katchalski
    • 1
  1. 1.Departments of Organic Chemistry and BiophysicsThe Weizmann Institute of ScienceRehovotIsrael

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