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Neurohypophyseal Hormones: Old and New Slants on the Relationship of Chemical Structure to Biological Activity

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The Chemistry of Polypeptides

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Abstract

Study of the relationship between the chemical structure and the biological activity of hormones has long been recognized as a valid approach to the elucidation of that initial chemical interplay between hormone and responsive cell which constitutes the primary step in hormone action. It would of course be desirable also to know the sequence and detailed nature of all other events leading to and including the final effector process for each of the final physiological effects of a given hormone on each of its target tissues. However, a thorough understanding of even the initial event in hormone action requires that structure-activity analysis be carried to the conformational level, and, indeed, work directed to this goal is under way (Walter et al. 1971). Nevertheless, the approach to the study of peptide hormone-receptor interaction at the three-dimensional (topochemical) level of structure must be regarded as derivative from antecedent classical structure-activity studies—for it is the primary structure of both hormone and receptor that determines the conformation of the active hormone-receptor complex.

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Authors and Affiliations

  1. Department of Physiology and Biophysics, Mount Sinai School of Medicine of the City University of New York, New York, NY, USA

    Irving L. Schwartz

  2. Brookhaven National Laboratory, Medical Research Center, New York, NY, USA

    Irving L. Schwartz

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  1. Irving L. Schwartz
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Editors and Affiliations

  1. Department of Biochemistry, Mount Sinai School of Medicine, City University of New York, New York, New York, USA

    P. G. Katsoyannis (Chairman) (Chairman)

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Schwartz, I.L. (1973). Neurohypophyseal Hormones: Old and New Slants on the Relationship of Chemical Structure to Biological Activity. In: Katsoyannis, P.G. (eds) The Chemistry of Polypeptides. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4571-8_14

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  • DOI: https://doi.org/10.1007/978-1-4613-4571-8_14

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