Oral Manifestations of IgA Deficiency

  • Paul B. Robertson
  • Max D. Cooper


The IgA system is viewed as a major local defense mechanism of mucous membranes, and IgA deficiency seems to be a significant predisposing factor to a variety of sino-pulmonary infections and intestinal disorders (1–6). Since IgA is the predominant immunoglobulin in secretions (7–10), including saliva, a protective role for this class of immunoglobulins in dental caries and periodontal disease has been suggested. Indeed, results of one investigation suggested that a deficient secretion of IgA in saliva might be associated with increased caries incidence (11). At present, however, the concept of immunity in dental caries is speculative and no conclusive evidence is available regarding the capacity of the IgA system to protect the periodontium (12–14). In addition, no description of the oral status of IgA deficient patients is available in the literature.


Periodontal Disease Otitis Medium Dental Caries Oral Hygiene Oral Manifestation 
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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • Paul B. Robertson
    • 1
  • Max D. Cooper
    • 1
  1. 1.Institute of Dental Research Departments of Pediatrics and MicrobiologyUniversity of Alabama in BirminghamBirminghamUSA

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