Isolation, Properties, and Structure of Human IgA Myeloma Globulins

  • Frank W. Putnam
  • Teresa Low
  • Victor Liu
  • Hans Huser
  • E. Raff
  • F. C. Wong
  • J. R. Clamp


For the past few years our work has been based on the principle that the characteristic covalent structure of 99% of all human immunoglobulins could be established by determining the amino acid sequence of five kinds of polypeptide chains: κ and λ light chains, and γ, μ, and a heavy chains. We reported the first complete sequence of κ (1) and λ (2,3) light chains. Others sequenced the γ chain (4,5) and we recently reported the complete sequence of the μ chain (6). The a chain is the last of the big five, and many laboratories are now engaged in its study.


Heavy Chain Tryptic Peptide Hinge Region Peptide Spot Hydroxyamino Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • Frank W. Putnam
    • 1
  • Teresa Low
    • 1
  • Victor Liu
    • 1
  • Hans Huser
    • 1
  • E. Raff
    • 1
  • F. C. Wong
    • 1
  • J. R. Clamp
    • 1
  1. 1.Department of ZoologyIndiana UniversityBloomingtonUSA

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