Isolation, Properties, and Structure of Human IgA Myeloma Globulins

  • Frank W. Putnam
  • Teresa Low
  • Victor Liu
  • Hans Huser
  • E. Raff
  • F. C. Wong
  • J. R. Clamp

Abstract

For the past few years our work has been based on the principle that the characteristic covalent structure of 99% of all human immunoglobulins could be established by determining the amino acid sequence of five kinds of polypeptide chains: κ and λ light chains, and γ, μ, and a heavy chains. We reported the first complete sequence of κ (1) and λ (2,3) light chains. Others sequenced the γ chain (4,5) and we recently reported the complete sequence of the μ chain (6). The a chain is the last of the big five, and many laboratories are now engaged in its study.

Keywords

Sulfide Carbohydrate Serine Proline Arginine 

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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • Frank W. Putnam
    • 1
  • Teresa Low
    • 1
  • Victor Liu
    • 1
  • Hans Huser
    • 1
  • E. Raff
    • 1
  • F. C. Wong
    • 1
  • J. R. Clamp
    • 1
  1. 1.Department of ZoologyIndiana UniversityBloomingtonUSA

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