Isolation, Properties, and Structure of Human IgA Myeloma Globulins
For the past few years our work has been based on the principle that the characteristic covalent structure of 99% of all human immunoglobulins could be established by determining the amino acid sequence of five kinds of polypeptide chains: κ and λ light chains, and γ, μ, and a heavy chains. We reported the first complete sequence of κ (1) and λ (2,3) light chains. Others sequenced the γ chain (4,5) and we recently reported the complete sequence of the μ chain (6). The a chain is the last of the big five, and many laboratories are now engaged in its study.
KeywordsHeavy Chain Tryptic Peptide Hinge Region Peptide Spot Hydroxyamino Acid
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