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Control of Transcription pp 355–372Cite as

Synthesis by Reverse Transcriptase of DNA Complementary to Globin Messenger RNA

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Part of the book series: Basic Life Sciences ((BLSC,volume 3))

Abstract

RNA tumor viruses contain a DNA polymerase that can synthesize a faithful DNA copy of viral RNA (1,5,23,25,26,31,32). This enzyme is easily released and purified from virions and can utilize a wide variety of polymers as templates (6,7,13,14,18,35,38). In order for a template to be copied, a primer or initiator that binds to the template by hydrogen bonds is required (3). The 3′-OH end of the primer is then covalently attached to the newly synthesized DNA (29). When the 60–70S tumor viral RNA is transcribed, the primer is apparently a short polyribonucleotide that is found attached to the DNA product (10,18,35,37).

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Authors and Affiliations

  1. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

    Inder M. Verma, Gary F. Temple, Hung Fan & David Baltimore

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  1. Inder M. Verma
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  2. Gary F. Temple
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  3. Hung Fan
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  4. David Baltimore
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Editors and Affiliations

  1. Bose Institute, Calcutta, India

    B. B. Biswas  & R. K. Mandal  & 

  2. Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA

    A. Stevens  & W. E. Cohn  & 

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© 1974 Plenum Press, New York

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Verma, I.M., Temple, G.F., Fan, H., Baltimore, D. (1974). Synthesis by Reverse Transcriptase of DNA Complementary to Globin Messenger RNA. In: Biswas, B.B., Mandal, R.K., Stevens, A., Cohn, W.E. (eds) Control of Transcription. Basic Life Sciences, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4529-9_28

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  • DOI: https://doi.org/10.1007/978-1-4613-4529-9_28

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4531-2

  • Online ISBN: 978-1-4613-4529-9

  • eBook Packages: Springer Book Archive

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