Motivational Effects of the Pituitary and Adrenal Hormones

  • F. R. Brush
  • J. C. Froehlich


Although it has been accepted as fact for many years that the hormones of reproduction affect a variety of reproductive as well as non-reproductive behaviors, only recently have the hormones of the pituitary and adrenal glands been viewed as behaviorally significant, thanks largely to the pioneering work of De Wied and his co-workers. As an index of the burgeoning interest in this area, review articles, conference summaries or major portions thereof, and entire volumes devoted to this topic have been appearing at an accelerating rate (James & Landon, 1968 Ganong & Martini, 1969; De Wied & Weijnen, 1970; Di Giusto et al., 1971; Sawyer & Gorski, 1971; Levine, 1972; Brodish & Redgate, 1973; Lissak, 1973; Smith, 1973; Zimmermann et al., 1973; Broverman et al., 1974).


Zinc Phosphate ACTH Secretion ACTH Release Adrenal Hormone Behavioral Manipulation 
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  1. ALLEN, J P, ALLEN, C.F., GREER, M.A., & JACOBS, J.J., 1973, Stress-induced secretion of ACTH, in “Brain-Pituitary-Adrenal Interrelationships,” (A. Brodish, & E. S. Redgate, eds.), pp. 99–127, S. Karger, New York.Google Scholar
  2. BASSETT, J. R., CAIRNCROSS, K. D., & KING, M. G., 1973, Parameters of novelty, shock predictability and response contingency in corticosterone release in the rat, Physiol. Behav. 10:901.PubMedCrossRefGoogle Scholar
  3. BERTOLINI, A., VERGONI, W., GESSA, G., & FERRARI, W., 1969, Induction of sexual excitement by the action of adrenocorticotropic hormone in brain, Nature 221:667.PubMedCrossRefGoogle Scholar
  4. BOHUS, B. 1973, Pituitary-adrenal influences on avoidance and approach behavior of the rat, in “Drug Effects on Neuroendocrine Regulation, Progress in Brain Research,” (E. Zimmerman, W. H. Gispen, B. H. Marks, & D. De Wied, eds.) 39:407, Elsevier, Amsterdam.CrossRefGoogle Scholar
  5. BOWERS, J. M., 1972, The role of shock and plasma corticosterone levels in retention of an avoidance response (unpublished Ph.D. thesis) University of Oregon Medical School.Google Scholar
  6. BRODISH, A., & REDGATE, E. S. (eds.) 1973, “Brain-Pituitary-Adrenal Interrelationships,” International Symposium on Brain-Pituitary-Adrenal Interrelationships, S. Karger, New York.Google Scholar
  7. BROVERMAN, D. M., KLAIBER, E. L., & VOGEL, W., 1974, Short-term versus long-term effects of adrenal hormones on behaviors, Psychol. Bull. 81:672.PubMedCrossRefGoogle Scholar
  8. BRUSH, F. R., 1971, Retention of aversively motivated behavior in “Aversive Conditioning and Learning,” (F. R. Brush, ed.), pp. 401–460, Academic Press, New York.Google Scholar
  9. BUCKINGHAM, J. C., & HODGES, J. R., 1974, The redox bioassay technique for the direct assessment of pituitary adrenocorticotrophic activity in the rat, Clin. Endocrin. 3:347.CrossRefGoogle Scholar
  10. CHALMERS, D. V., HOHF, J. C., & LEVINE, S., 1974, The effects of prior aversive stimulation on the behavioral and physiological responses to intense acoustic stimuli in the rat, Physiol Behav. 12:711.PubMedCrossRefGoogle Scholar
  11. CHAYEN, J., LOVERIDGE, N., & DALY, J. R., 1972, A sensitive bioassay for adrenocorticotrophic hormone in human plasma, Clin. Endocrin. 3:219.CrossRefGoogle Scholar
  12. CIARANELLO, R. D., BARGHAS, J. D., & VERNIKOS-DANELLIS, J, 1969, Compensatory hypertrophy and phenylethanolamine N-methyl transferase (PNMT) activity in the rat adrenal, Life Sci. 8:401, part 1.PubMedCrossRefGoogle Scholar
  13. CLEGG, P. C., & CLEGG, A. G., 1969, “Hormones, Cells and Organisms, the Role of Hormones in Mammals,” Stanford University Press, Stanford.Google Scholar
  14. CONNER, R. L., & LEVINE, S., 1969, The effect of adrenal hormones on the acquisition of signalled avoidance behavior, Horm. Behav. 1:73.CrossRefGoogle Scholar
  15. CONNER, R. L., VERNIKOS-DANELLIS, J., & LEVINE, S, 1971, Stress, fighting and neuroendocrine function, Nature 234:564.PubMedCrossRefGoogle Scholar
  16. COOVER, G. D., GOLDMAN, D. L., & LEVINE, S., 1971a, Plasma corticosterone levels during extinction of a lever-press response in hippocampectomized rat, Physiol. Behav. 7:727.PubMedCrossRefGoogle Scholar
  17. COOVER, G., GOLDMAN, D. L., & LEVINE, S., 1971b, Plasma corticosterone increases produced by extinction of operant behavior in rats, Physiol. Behav. 6:261.PubMedCrossRefGoogle Scholar
  18. COOVER, G. D., URSIN, H., & LEVINE, S., 1973, Plasma corticosterone levels during active-avoidance learning in rats, J. Comp. Physiol. Psychol. 82:170.PubMedCrossRefGoogle Scholar
  19. DALLMAN, M. F., & JONES, M. T., 1973a, Corticosteroid feedback control of stress-induced ACTH secretion, In “Brain-Pituitary-Adrenal Interrelationships,” (A. Brodish & E. S. Redgate, eds.), pp. 176–196, S. Karger, New York.Google Scholar
  20. DALLMAN, M. F., & JONES, M. T., 1973b, Corticosteroid feedback control of ACTH secretion: Effect of stress-induced corticosterone secretion on subsequent stress responses in the rat, Endocrinology 92:1367.PubMedCrossRefGoogle Scholar
  21. DALLMAN, M. F., & YATES, F. E., 1968, Anatomical and functional mapping of central neural input and feedback pathways of the adrenocortical system, in “The Investigation of Hypothalamic-Pituitary-Adrenal Function,” (V. H. T. James & J. Landon, eds.), pp. 39–72, Cambridge University Press, Cambridge.Google Scholar
  22. DALLMAN, M. F., & YATES, F. E., 1969, Dynamic asymmetries in the corticosteroid feedback path and distribution-metabolism-binding elements of the adrenocortical system, Ann. N. Y. Acad. Sci. 156:696.PubMedCrossRefGoogle Scholar
  23. DEMPSEY, G. L., KASTIN, A. J., & SCHALLY, A. V., 1972, The effects of MSH on a restricted passive avoidance response, Horm. Behav. 3:333.CrossRefGoogle Scholar
  24. DE WIED, D., VAN DELFT, A. M. L., GISPEN, W. H., WEIJNEN, J. A. W. M. & VAN WIMERSMA GREIDANUS, Tj. B., 1972, The role of pituitary-adrenal system hormones in active avoidance conditioning, in “Active Avoidance Conditioning,” (S. Levine, ed.) pp. Academic Press, New York.Google Scholar
  25. DE WIED, D., & WEIJNEN, J. A. W. M. (eds.), 1970, “Pituitary, Adrenal and the Brain, Progress in Brain Research,” v. 32, Elsevier, Amsterdam.Google Scholar
  26. DI GIUSTO, E. L., 1972, Adrenaline or peripheral noradrenaline depletion and passive avoidance in the rat, Physiol. Behav. 8:1059.PubMedCrossRefGoogle Scholar
  27. DI GIUSTO, E. L., CAIRNCROSS, K., & KING, M. G., 1971, Hormonal influences on fear-motivated responses, Psychol. Bull. 75: 432–442.PubMedCrossRefGoogle Scholar
  28. DI GIUSTO, E. L., KING, M. G., 1972, Chemical sympathectomy and avoidance learning in the rat, J. Comp. Physiol. Psychol. 81:491–500.PubMedCrossRefGoogle Scholar
  29. DUFFY, E., 1962, “Activation and Behavior,” Wiley, New York.Google Scholar
  30. FORTIER, C., & DEGROOT, J., 1959, Adenohypophyseal corticotropin and plasma free corticosteroids during regeneration of the enucleated rat adrenal gland, Amer. J. Physiol. 196:589.PubMedGoogle Scholar
  31. FROEHLICH, J. C., 1974, The effect of injected corticosterone on the adrenal response in rats exposed to ether and cold stress (Unpublished M. S. Thesis), Syracuse University.Google Scholar
  32. GANONG, W. F., & MARTINI, L. (eds.), “frontiers in Neuroendocrinology,” 1969, Oxford, New York.Google Scholar
  33. GANONG, W. F., & MARTINI, L. (eds.), 1973, “Frontiers in Neuroendocrine logy,” Oxford, New York.Google Scholar
  34. GARRUD, P., GRAY, J. A., & DE WIED, D., 1974, Pituitary-adrenal hormones and extinction of rewarded behaviour in the rat, Physiol. Behav. 12:109.PubMedCrossRefGoogle Scholar
  35. GISPEN, W. H., VAN WIMERSMA GREIDANUS, T. B., & DE WIED, D., 1970, Effects of hypophysectomy and ACTH1–10 on responsiveness to electric shock in rats, Physiol. Behav. 5:143.PubMedCrossRefGoogle Scholar
  36. GOLDMAN, L., COOVER, G. D., LEVINE, S., 1973, Bidirectional effects of reinforcement shifts on pituitary adrenal activity, Physiol. Behav. 10:209.PubMedCrossRefGoogle Scholar
  37. GUTH, S., LEVINE, S., & SEWARD, J. P., 1971, Appetetive acquisition and extinction effects with exogenous ACTH, Physiol. Behav. 7:195.PubMedCrossRefGoogle Scholar
  38. GUTH, S., SEWARD, J. P., & LEVINE, S., 1971, Differential manipulation of passive avoidance by exogenous ACTH, Horm. Behav. 2:127.CrossRefGoogle Scholar
  39. HARRIS, R. K., 1973, Acquisition of conditioned avoidance response by hypophysectomized rats, J. Comp. Physiol. Psychol. 82:254.PubMedCrossRefGoogle Scholar
  40. HEBB, D. O., 1955, Drives and the C. N. S. (conceptual nervous system), Psychol. Rev. 62:243.PubMedCrossRefGoogle Scholar
  41. HENKIN, R. I., 1970, The effects of corticosteroids and ACTH on sensory systems, In “Pituitary, Adrenal and the Brain, Progress in Brain Research,” (D. De Wied & J. A. W. M. Weijnen, eds.), 32:270–294, Elsevier, Amsterdam.CrossRefGoogle Scholar
  42. HODGES, J. R., & JONES, M. T., 1964, Changes in pituitary corticotropic function in adrenalectomized rat, J. Physiol. 173: 190.PubMedGoogle Scholar
  43. HUCKLEBRIDGE, F. H., & NOWELL, N. W., 1974, Plasma catecholomine response to physical and psychological aspects of fighting in mice, Physiol. Behav. 13:35.PubMedCrossRefGoogle Scholar
  44. JAMES, V. H. T., & LANDON, J. (eds.), 1968, “The Investigation of Hypothalamic-Pituitary-Adrenal Function,” Cambridge University Press, Cambridge.Google Scholar
  45. JONES, M. T., BRUSH, F. R., & NEAME, R. L. B., 1972, Characteristics of fast feedback control of corticotrophin release by corticosteroids, J. Endocrin. 55:489.CrossRefGoogle Scholar
  46. JONES, M. F., TIPTAFT, E. M., BRUSH, F. R., FERGUSSON, D. A. N., & NEAME, R. L. B., 1974, Evidence for dual corticosteroid receptor mechanisms in the feedback control of adrenocorticotrophin secretion, J. Endocrin. 60:223.CrossRefGoogle Scholar
  47. LESHNER, A. I., BROOKSHIRE, K. H., & STEWART, C. N., 1971, The effects of adrenal demedullation on conditioned fear, Horm. Behav. 2:43.CrossRefGoogle Scholar
  48. LEVINE, S., 1968, Hormones and conditioning, in “Nebraska Symposium on Motivation,” (W. J. Arnold, ed.), pp. 85–101, University of Nebraska Press, Lincoln.Google Scholar
  49. LEVINE, S. (ed.), 1972, “Hormones and Behavior,” Academic Press, New York.Google Scholar
  50. LEVINE, S., & MULLINS, R. F., JR., 1966, Hormonal influences on brain organization in infant rats, Science 152:1585.PubMedCrossRefGoogle Scholar
  51. LEY, K. F., & CORSON, J. A., 1970, Effects of ACTH and zinc phosphate vehicle on shuttlebox CAR, Psychon. Sci. 20:307–309.Google Scholar
  52. LEY, K. F., & CORSON, J. A., 1971, ACTH and zinc phosphate vehicle interact with UCS parameters to influence shuttlebox CAR, Horm. Behav. 2:149.CrossRefGoogle Scholar
  53. LISSAK, R. (ed.), 1973, “Hormones and Brain Function,” Plenum Press, New York.Google Scholar
  54. LISSAK, R., & ENDROCZI, E., 1967, Involvement of limbic structures in conditioning, motivation, and recent memory, in “Structure and Function of the Limbic System”. Progress in Brain Research, (W. R. Adey & T. Tokizane, eds.) 22:246–253, Elsevier, Amsterdam.CrossRefGoogle Scholar
  55. MADDEN, J., ROLLINS, J., ANDERSON, D. C., CONNER, R. L., & LEVINE, S., 1971, Preshock-produced intensification of passive avoidance responding and of elevation in corticosteroid level, Physiol. Behav. 7:733.PubMedCrossRefGoogle Scholar
  56. MARKS, B. H., & VERNIKOS-DANELLIS, J., 1963, Effects of acute stress on the pituitary gland: Action of ethionine on stress-induced ACTH release, Endocrinology 72:582.CrossRefGoogle Scholar
  57. MARTINI, L., & GANONG, W. F. (eds.), 1967, “Neuroendocrinology,” Academic Press, New York.Google Scholar
  58. MOTTA, M., FRASCHINI, F., & MARTINI, L., 1969, “Short” feedback mechanisms in the control of anterior pituitary function in “Frontiers in Neuroendocrinology,” (W. F. Ganong & L. Martini, eds.) pp. 211–254, Oxford, New York.Google Scholar
  59. OVERTON, D. A., 1964, State dependent or “dissociated” learning produced with pentobarbital, J. Comp. Physiol. Psychol. 57:3.PubMedCrossRefGoogle Scholar
  60. PAGANO, R. R., & LOVELY, R. H., 1972, Diurnal cycle and ACTH facilitation of shuttlebox avoidance, Physiol. Behav. 8:721.PubMedCrossRefGoogle Scholar
  61. PAPPAS, B. A., & GRAY, P., 1971, Cue value of dexamethasone for fear-motivated behavior, Physiol. Behav. 6:127.PubMedCrossRefGoogle Scholar
  62. PARÉ, W. P., & CULLEN, J. W., 1971, Adrenal influences on the aversive threshold and CER acquisition, Horm. Behav. 2:139.CrossRefGoogle Scholar
  63. SAKELLARIS, P. C., 1972, Olfactory thresholds in normal and adrenalectomized rats, Physiol. Behav. 9:495.PubMedGoogle Scholar
  64. SAKELLARIS, P. C., & VERNIKOS-DANELLIS, J., 1974a, Alteration of pituitary-adrenal dynamics induced by a water deprivation regimen, Physiol. Behav. 12:1067.PubMedCrossRefGoogle Scholar
  65. SAKELLARIS, P. C. & VERNIKOS-DANELLIS, J., 1974b, Hyper-reactivity of the pituitary-adrenal system in rats adapted to chronic stress, Endocrinology (in press).Google Scholar
  66. SANDMAN, C. A., BECKWITH, B. E., GITTIS, M. M., & KASTIN, A. J., 1974, Melanocyte-stimulating hormones (MSH) and overtraining affects on extradimensional shift (EDS) learning, Physiol. Behav. 13:162.CrossRefGoogle Scholar
  67. SANDMAN, C. A., DENMAN, P. M., MILLER, L. H., KNOTT, J. R., SCHALLY, A. V., & KASTIN, A. J., 1971, Electroencephalographic measures of melanocyte-stimulating hormone activity, J. Comp. Physiol. Psychol. 76:103.PubMedCrossRefGoogle Scholar
  68. SANDMAN, C. A., KASTIN, A. J., & SCHALLY, A. V., 1969, Melanocyte-stimulating hormone and learned appetitive behavior, Experientia 25:1001.PubMedCrossRefGoogle Scholar
  69. SANDMAN, C. A., KASTIN, A. J., & SCHALLY, A. V., 1971, Behavioral inhibition as modified by melanocyte-stimulating hormone (MSH) and light-dark conditions, Physiol. Behav. 6:45.PubMedCrossRefGoogle Scholar
  70. SANDMAN, C. A., KASTIN, A. J., SCHALLY, A. V., KENDALL, J. W., MILLER, L. H., 1973, Neuroendocrine responses to physical and psychological stress, J. Comp. Physiol. Psychol. 84:386.PubMedCrossRefGoogle Scholar
  71. SANDMAN, C. A., MILLER, L. H., KASTIN, A. J., & SCHALLY, A. V., 1972, A neuroendocrine influence on attention and memory, J. Comp. Physiol. Psychol. 80:54.PubMedCrossRefGoogle Scholar
  72. SAWYER, C. H., & GORSKI, R. A. (eds.), 1971, “Steroid Hormones and Brain Function, UCLA Forum in Medical Sciences, Number 15,” University of California Press, Berkeley.Google Scholar
  73. SAYERS, G., & SAYERS, M. A., 1947, Regulation of pituitary adrenocorticotropic activity during the response of the rat to acute stress, Endocrinology 40:265.PubMedCrossRefGoogle Scholar
  74. SCHAYER, R. W., 1964, A unified theory of glucocorticoid action, Perspect. Biol. Med. 8:71.Google Scholar
  75. SCHAYER, R. W., 1967, A unified theory of glucocorticoid action, II, on a circulatory basis for the metabolic effects of glucocorticoids, Perspect. Biol. Med. 10:409.PubMedGoogle Scholar
  76. SELIGMAN, M. E. P., MAIER, S. F., & SOLOMON, R. L., 1971, Unpredictable and uncontrollable aversive events, in “Aversive Conditioning and Learning,” (F. R. Brush, ed.) pp. 347–401.Google Scholar
  77. SELYE, H., 1950, “Stress,” ACTA, Montreal.Google Scholar
  78. SMELIK, P. G., 1963, Relation between blood levels of corticoids and their inhibiting effects on the hypophyseal stress response, Proc. Soc. Exp. Biol. Med. 113:616.PubMedGoogle Scholar
  79. SMELIK, P. L., 1969, The regulation of ACTH secretion, Acta Physiol. Pharm. 15:123–135, Netherlands.Google Scholar
  80. SMITH, G. P., 1973, Adrenal Hormones and Emotional Behavior, in “Progress in Physiological Psychology,” (E. Stellar & J. M. Sprague, eds.), pp. 291–351, Academic Press, New York.Google Scholar
  81. TAYLOR, A. N., MATHESON, G. K., & DAFNY, N., 1971, Modification of the responsiveness of components of the limbic-midbrain circuit by corticosteroids and ACTH, in “Steroid Hormones and Brain Function, UCLA Forum in Medical Sciences, Number 15,” (C. H. Sawyer & R. A. Gorski, eds.), pp. 67–68, University of California Press, Berkeley.Google Scholar
  82. VAN LOON, G. R., 1973, Brain catecholamines and ACTH secretion, in “Frontiers in Neuroendocrinology,” (W. F. Ganong & L. Martini, eds.), pp. 209–247, Oxford Press, New York.Google Scholar
  83. VERNIKES-DANELLIS, J., 1968, The pharmacological approach to the study of the mechanisms regulating ACTH secretion, in “Pharmacology of Hormonal Polypeptides and Proteins,” (N. Back, L. Martini, and R. Paoletti, eds.), pp. 175–189, Plenum Press, New York.Google Scholar
  84. VERNIKOS-DANELLIS, J., CIARANELLO, R. D., & BARCHAS, J. D., 1968, Adrenal epinephrine and phenylethanolainine N-methyl transferase (PNMT) activity in the rat having a transplantable pituitary tumor, Endocrinology 83:1357.PubMedCrossRefGoogle Scholar
  85. VERNIKOS-DANELLIS, J., & MARKS, B. H., 1962, Epinephrine-induced release of ACTH in normal human subjects: A test of pituitary function, Endocrinology 70:525.PubMedCrossRefGoogle Scholar
  86. WEIJNEN, J. A. W. M., & SLANGEN, J. L., 1970, Effects of ACTH analogues on extinctions of conditioned behavior, in “Pituitary, Adrenal and the Brain, Progress in Brain Research,” (D. De Wied & J. A. W. M. Weijnen, eds.), 32:221–235, Elsevier, Amsterdam.CrossRefGoogle Scholar
  87. WEISS, J. M., & GRAY, P., 1973, Hormones and avoidance behavior: A different approach points to a role for mineralocorticoids, in “Drug Effects on Neuroendocrine Regulation, Progress in Brain Research,” (D. De Wied & J. A. W. M. Weijnen, (eds.) 39:471–480, Elsevier, Amsterdam.CrossRefGoogle Scholar
  88. WEISS, J. M., MCEWEN, B. S., SILVA, M. T., & KALKNUT, M. F., 1970, Pituitary-adrenal alterations and fear responding, Amer. J. Physiol. 218:864.PubMedGoogle Scholar
  89. WEISS, J. M., MCEWEN, B. S., TERESA, M., SILVA, A., & KALKUT, M. F., 1969, Pituitary-adrenal influences on fear responding, Science 163:197.PubMedCrossRefGoogle Scholar
  90. YATES, F. E., LEEMAN, S. E., GLENISTER, D. W., & DALLMAN, M. F., 1961, Interaction between plasma corticosterone concentration and adrenocorticotrophin-releasing stimuli in the rat: evidence for the reset of an endocrine feedback control, Endocrinology 69:67.PubMedCrossRefGoogle Scholar
  91. ZIMMERMANN, E., GISPEN, W. H., MARKS, B. H., & DE WIED, D. (eds.) “Drug Effects on Neuroendocrine Regulation Progress in Brain Research, Volume 39,” Elsevier, Amsterdam.Google Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • F. R. Brush
    • 1
  • J. C. Froehlich
    • 1
  1. 1.Experimental Psychology LaboratorySyracuse UniversitySyracuseUSA

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