Biophysical Aspects of Radiation Carcinogenesis

  • Albrecht M. Kellerer
  • Harald H. Rossi

Abstract

Although radiation carcinogenesis was recognized some 75 years ago, we still know virtually nothing of the mechanisms involved. Because of its profoundly important theoretical and practical aspects, the phenomenon has been very extensively studied, but most of the information obtained has been of a phenomenological nature.

Keywords

Leukemia Adenocarcinoma Iodine Radium Radioactive Isotope 

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References

  1. Bach, R. L., and Caswell, R. S., 1968, Energy transfer to matter by neutron, Radiation Res. 35: 1–25.PubMedCrossRefGoogle Scholar
  2. Bateman, J. L., Rossi, H. H., Kellerer, A. M., Robinson, C. V., and Bond, V. P., 1972, Dose dependence of fast neutron RBE for lens opacification in mice. Radiation Res. 51: 381–390.PubMedCrossRefGoogle Scholar
  3. Biola, M. T., LeGo, R., Ducatez, G., and Bourguignon, M., 1971, Formation de Chromosomes Dicentriques dans les Lymphocytes Humains Soumis in Vitro a un Flux de Rayonnement Mixte (Gamma, Neutrons), pp. 633–645, IAEA, Vienna.Google Scholar
  4. Bond, V. P., Cronkite, E. P., Lippincott, S. W., and Shellabarger, C. J., 1960, Studies on radiation induced mammary gland neoplasia in the rat. Radiation Res. 12: 276–285.PubMedCrossRefGoogle Scholar
  5. Borek, C., and Hall, E. J., 1973, Transformation of mammalian cells in vitro by low doses of X-rays, Nature (Lond.) 244: 450–453.CrossRefGoogle Scholar
  6. Brenot, J., Chemtob, M., Chmelevsky, D., Fache, P., Parmentier, N., Soulie, R., Biola, M. T., Haag, J., Lego, R., Bourguignon, M., Courant, D., Dacher, J., and Ducatez, G., 1973, Aberrations chromosomiques et microdosimetrie, in: Proceedings of the IV Symposium of Microdosimetry, Verbania, 1973, Euratom, Brussels.Google Scholar
  7. Brewen, J. G., Preston, R. J., Jones, K. P., and Gosslee, D. C., 1973, Genetic hazards of ionizing radiations: Cytogenetic extrapolations from mouse to man. Mutation Res. 17: 245–254.PubMedCrossRefGoogle Scholar
  8. Cole, A., 1967, Chromosome structure, in: Theoretical and Experimental Biophysics, Vol. I ( A. Cole, ed.), Dekker, New York.Google Scholar
  9. Dewey, W. C., Noel, J. S., and Dettor, C. M., 1972, Changes in radiosensitivity and dispension of chromatin during the cell cycle of synchronous Chinese hamster cells, Radiation Res. 52: 373–394.PubMedCrossRefGoogle Scholar
  10. Field, St. B., 1969, The relative biological effectiveness of fast neutrons for mammalian tissues, Radiology 93: 915–920.PubMedGoogle Scholar
  11. Hall, E. J., Rossi, H. H., Kellerer, A. M., Goodman, L. J., and Marino, S., 1973, Radiobiological studies with monoenergetic neutrons, Radiation Res. 54: 431–443.PubMedCrossRefGoogle Scholar
  12. Hughes, D. J., and Schwartz, R. B., 1958, Neutron Cross Sections, Brookhaven National Laboratory, Document 325, Government Printing Office, Washington, D.C.Google Scholar
  13. ICRU, 1970, Report 16: Linear Energy Transfer, International Commission on Radiation Units and Measurements, Washington, D.C.Google Scholar
  14. ICRU, 1971, Report 19: Radiation Quantities and Units, International Commission on Radiation Units and Measurements, Washington, D.C.Google Scholar
  15. Ishimaru, T., Hoshino, T., Ichimaru, M., Okada, H., Tomiyasu, T., and Tsuchimoto, T., 1971, Leukemia in atomic bomb survivors, Hiroshima and Nagasaki, 1 October 1950–30 September 1966, Radiation Res. 45: 216–233.PubMedCrossRefGoogle Scholar
  16. Kellerer, A. M., and Brenot, J., 1973, Nonparametric determination of modifying factors in radiation action, Radiation Res. 55: 28–39.CrossRefGoogle Scholar
  17. Kellerer, A. M., and Brenot, J., 1974, On the statistical evaluation of dose-response functions, Rad. Environm. Biophys. 11: 1–13.CrossRefGoogle Scholar
  18. Kellerer, A. M., and Hug, O., 1972, Theory of dose-effect relations, in: Encyclopedia of Medical Radiology, Vol. II/3, 1–42, Springer, New York.Google Scholar
  19. Kellerer, A. M., and Rossi, H. H., 1972, The theory of dual radiation action, in: Current Topics in Radiation Research, Vol. 8, pp. 85–158, North-Holland, Amsterdam.Google Scholar
  20. Lea, D. E., 1946, Actions of Radiations on Living Cells, Cambridge University Press, Cambridge.Google Scholar
  21. Rossi, H. H., 1964, Correlationof radiation quality and biological effect, Ann. N.Y.Acad. Sci. 114: 4–15 (Art. 1).Google Scholar
  22. Rossi, H. H., and Kellerer, A. M., 1972, Radiation carcinogenesis at low doses. Science 175: 200–202.PubMedCrossRefGoogle Scholar
  23. Rossi, H. H., and Kellerer, A. M., 1974, Thevalidityof risk estimates of leukemia incidence based on Japanese data. Radiation Res. 58: 131–140.PubMedCrossRefGoogle Scholar
  24. Savage, J. R. K., 1970, Sites of radiation induced chromosome exchanges, in: Current Topics in Radiation Research, pp. 131–194, North-Holland, Amsterdam.Google Scholar
  25. Sax, K., 1938, Chromosome aberrations induced by X-rays, Genetics 23: 494–516.PubMedGoogle Scholar
  26. Sax, K., 1941, Types and frequencies of chromosomal aberrations induced by X-rays, Cold Spring Harbor Symp. Quant. Biol. 9: 93.Google Scholar
  27. Schmid, E., Rimpl, G., and Bauchinger, M., 1973, Dose-response relation of chromosome aberra¬tions in human lymphocytes after in vitro irradiation with 3 MeV electrons, Radiation Res. 57: 228–238.CrossRefGoogle Scholar
  28. Shellabarger, C. J., Bond, V. P., Cronkite, E. P., and Aponte, G. E., 1969, Relationship of dose of total-body radiation to incidence of mammary neoplasia in female rats. Radiation-Induced Cancer, IAEA-SM-118/9.Google Scholar
  29. Shellabarger, C. J., Kellerer, A. M., Rossi, H. H., Goodman, L. J., Brown, R. D., Mills, R. E., Rao, A. R., Shanley, J. P., and Bond, V. P., 1974, Rat mammary carcinogenesis following neutron or X-irradiation, in: Biological Effects of Neutron Irradiation, IAEA, Vienna.Google Scholar
  30. Sinclair, W. K., 1968, The shape of radiation survival curves of mammalian cells cultured in vitro, in: Biophysical Aspects of Radiation Quality, IAEA, Vienna.Google Scholar
  31. Smith, H. H., Combatti, N. C., and Rossi, H. H., 1968, Response of seeds to irradiation with X-rays 439 and neutrons over a wide range of doses, in: Neutron Irradiation of Seeds, Vol. II, Technical Report Series No. 92, pp. 3–8, IAEA, Vienna.Google Scholar
  32. Sparrow, A. H., Underbrink, A. G., and Rossi, H. H., 1972, Mutations induced in Tradescantia by small doses of X-rays and neutrons. Analysis of dose-response curves. Science 176: 916–918.PubMedCrossRefGoogle Scholar
  33. Vogel, H. H., 1969, Mammary gland neoplasms after fission neutron irradiation. Nature (Lond.) 222: 1279–1281.CrossRefGoogle Scholar
  34. Withers, H. H., Brennan, J. T., and Elkind, M. M., 1970, The response of stem cells of intestinal mucosa to irradiation with 14 MeV neutrons, Brit. J. Radiol. 43: 796–801.PubMedCrossRefGoogle Scholar
  35. Wolf, S., 1954, Delay of chromosome rejoining in Vicia faba induced by irradiation, Nature (Lond.) 173: 501–502.CrossRefGoogle Scholar

Selected General References Section 2

  1. Attix, F. H., and Roesch, W. C., 1968, Radiation Dosimetry, Vol. I: Fundamentals, Academic Press, New York.Google Scholar
  2. Hine, G. J., and Brownell, G. L., 1956, Radiation Dosimetry, Academic Press, New York.Google Scholar
  3. ICRU, 1970, Report 16: Linear Energy Transfer, International Commission on Radiation Units and Measurements, Washington, D.C.Google Scholar
  4. ICRU, 1971, Report 19: Radiation Quantities and Units, International Commission on Radiation Units and Measurements, Washington, D.C.Google Scholar
  5. Rossi, H. H., 1967, Energy distribution in the absorption of radiadon, Advan. Biol. Med. Phys. 11: 27–85.Google Scholar
  6. Whyte, G. N., 1959, Principles of Radiation Dosimetry, Wiley, New York.Google Scholar

Section 3

  1. Elkind, M., and Whitmore, G., 1967, The Radiobiology of Cultured Mammalian Cells, Gordon and Breach, London.Google Scholar
  2. Fisz, M., 1965, Probability Theory and Mathematical Statistics, Wiley, New York.Google Scholar
  3. Hug, O., and Kellerer, A. M., 1966, Stochastik der Strahlenwirkung, Springer, New York.Google Scholar
  4. Kellerer, A. M., and Hug, O., 1972, Theory of dose-affect relations, in: Encyclopedia of Medical Radiology, Vol. II/3, pp. 1–42, Springer, New York.Google Scholar
  5. Zimmer, K. G., 1961, Studies on Quantitative Radiation Biology, Oliver and Boyd, London.,Google Scholar

Section 4

  1. Kellerer, A. M., and Rossi, H. H., 1972, The theory of dual radiation action, in: Current Topics in Radiation Research, Vol. 8, pp. 85–158, North-Holland.Google Scholar
  2. Lea, D. E., 1946, Actions of Radiations on Living Cells, Cambridge University Press, Cambridge.Google Scholar
  3. Rossi, H. H., 1970, The effects of small doses of ionizing radiation, Phys. Med. Biol. 15: 255–262.PubMedCrossRefGoogle Scholar
  4. Savage, J. R. K., 1970, Sites of radiation induced chromosome exchanges, in: Current Topics of Radiation Research, pp. 131–194, North-Holland, Amsterdam.Google Scholar

Section 5

  1. National Academy of Sciences-National Research Council, 1972, The Effects on Populations of Exposure to Low Levels of Ionizing Radiation, Washington, D.C.Google Scholar
  2. U.S. Atomic energy commission, 1973, Radionuclide Carcinogenesis, CONF-720505, AEC Symposium Series 29, Washington, D.C.Google Scholar
  3. United Nations, 1972, Ionizing Radiation: Levels and Effects, Vol. I, New York.Google Scholar
  4. United Nations, 1972, Ionizing Radiation: Levels and Effects, Vol. II, New York.Google Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Albrecht M. Kellerer
    • 1
  • Harald H. Rossi
    • 1
  1. 1.Department of RadiologyColumbia University College of Physicians and SurgeonsNew YorkUSA

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