Abstract
Although radiation carcinogenesis was recognized some 75 years ago, we still know virtually nothing of the mechanisms involved. Because of its profoundly important theoretical and practical aspects, the phenomenon has been very extensively studied, but most of the information obtained has been of a phenomenological nature.
This investigation was supported by Contract AT(11-1)-3243 from the United States Atomic Energy Commission and by Public Health Service Research Grant No. CA12536-03 from the National Cancer Institute.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Bach, R. L., and Caswell, R. S., 1968, Energy transfer to matter by neutron, Radiation Res. 35: 1–25.
Bateman, J. L., Rossi, H. H., Kellerer, A. M., Robinson, C. V., and Bond, V. P., 1972, Dose dependence of fast neutron RBE for lens opacification in mice. Radiation Res. 51: 381–390.
Biola, M. T., LeGo, R., Ducatez, G., and Bourguignon, M., 1971, Formation de Chromosomes Dicentriques dans les Lymphocytes Humains Soumis in Vitro a un Flux de Rayonnement Mixte (Gamma, Neutrons), pp. 633–645, IAEA, Vienna.
Bond, V. P., Cronkite, E. P., Lippincott, S. W., and Shellabarger, C. J., 1960, Studies on radiation induced mammary gland neoplasia in the rat. Radiation Res. 12: 276–285.
Borek, C., and Hall, E. J., 1973, Transformation of mammalian cells in vitro by low doses of X-rays, Nature (Lond.) 244: 450–453.
Brenot, J., Chemtob, M., Chmelevsky, D., Fache, P., Parmentier, N., Soulie, R., Biola, M. T., Haag, J., Lego, R., Bourguignon, M., Courant, D., Dacher, J., and Ducatez, G., 1973, Aberrations chromosomiques et microdosimetrie, in: Proceedings of the IV Symposium of Microdosimetry, Verbania, 1973, Euratom, Brussels.
Brewen, J. G., Preston, R. J., Jones, K. P., and Gosslee, D. C., 1973, Genetic hazards of ionizing radiations: Cytogenetic extrapolations from mouse to man. Mutation Res. 17: 245–254.
Cole, A., 1967, Chromosome structure, in: Theoretical and Experimental Biophysics, Vol. I ( A. Cole, ed.), Dekker, New York.
Dewey, W. C., Noel, J. S., and Dettor, C. M., 1972, Changes in radiosensitivity and dispension of chromatin during the cell cycle of synchronous Chinese hamster cells, Radiation Res. 52: 373–394.
Field, St. B., 1969, The relative biological effectiveness of fast neutrons for mammalian tissues, Radiology 93: 915–920.
Hall, E. J., Rossi, H. H., Kellerer, A. M., Goodman, L. J., and Marino, S., 1973, Radiobiological studies with monoenergetic neutrons, Radiation Res. 54: 431–443.
Hughes, D. J., and Schwartz, R. B., 1958, Neutron Cross Sections, Brookhaven National Laboratory, Document 325, Government Printing Office, Washington, D.C.
ICRU, 1970, Report 16: Linear Energy Transfer, International Commission on Radiation Units and Measurements, Washington, D.C.
ICRU, 1971, Report 19: Radiation Quantities and Units, International Commission on Radiation Units and Measurements, Washington, D.C.
Ishimaru, T., Hoshino, T., Ichimaru, M., Okada, H., Tomiyasu, T., and Tsuchimoto, T., 1971, Leukemia in atomic bomb survivors, Hiroshima and Nagasaki, 1 October 1950–30 September 1966, Radiation Res. 45: 216–233.
Kellerer, A. M., and Brenot, J., 1973, Nonparametric determination of modifying factors in radiation action, Radiation Res. 55: 28–39.
Kellerer, A. M., and Brenot, J., 1974, On the statistical evaluation of dose-response functions, Rad. Environm. Biophys. 11: 1–13.
Kellerer, A. M., and Hug, O., 1972, Theory of dose-effect relations, in: Encyclopedia of Medical Radiology, Vol. II/3, 1–42, Springer, New York.
Kellerer, A. M., and Rossi, H. H., 1972, The theory of dual radiation action, in: Current Topics in Radiation Research, Vol. 8, pp. 85–158, North-Holland, Amsterdam.
Lea, D. E., 1946, Actions of Radiations on Living Cells, Cambridge University Press, Cambridge.
Rossi, H. H., 1964, Correlationof radiation quality and biological effect, Ann. N.Y.Acad. Sci. 114: 4–15 (Art. 1).
Rossi, H. H., and Kellerer, A. M., 1972, Radiation carcinogenesis at low doses. Science 175: 200–202.
Rossi, H. H., and Kellerer, A. M., 1974, Thevalidityof risk estimates of leukemia incidence based on Japanese data. Radiation Res. 58: 131–140.
Savage, J. R. K., 1970, Sites of radiation induced chromosome exchanges, in: Current Topics in Radiation Research, pp. 131–194, North-Holland, Amsterdam.
Sax, K., 1938, Chromosome aberrations induced by X-rays, Genetics 23: 494–516.
Sax, K., 1941, Types and frequencies of chromosomal aberrations induced by X-rays, Cold Spring Harbor Symp. Quant. Biol. 9: 93.
Schmid, E., Rimpl, G., and Bauchinger, M., 1973, Dose-response relation of chromosome aberra¬tions in human lymphocytes after in vitro irradiation with 3 MeV electrons, Radiation Res. 57: 228–238.
Shellabarger, C. J., Bond, V. P., Cronkite, E. P., and Aponte, G. E., 1969, Relationship of dose of total-body radiation to incidence of mammary neoplasia in female rats. Radiation-Induced Cancer, IAEA-SM-118/9.
Shellabarger, C. J., Kellerer, A. M., Rossi, H. H., Goodman, L. J., Brown, R. D., Mills, R. E., Rao, A. R., Shanley, J. P., and Bond, V. P., 1974, Rat mammary carcinogenesis following neutron or X-irradiation, in: Biological Effects of Neutron Irradiation, IAEA, Vienna.
Sinclair, W. K., 1968, The shape of radiation survival curves of mammalian cells cultured in vitro, in: Biophysical Aspects of Radiation Quality, IAEA, Vienna.
Smith, H. H., Combatti, N. C., and Rossi, H. H., 1968, Response of seeds to irradiation with X-rays 439 and neutrons over a wide range of doses, in: Neutron Irradiation of Seeds, Vol. II, Technical Report Series No. 92, pp. 3–8, IAEA, Vienna.
Sparrow, A. H., Underbrink, A. G., and Rossi, H. H., 1972, Mutations induced in Tradescantia by small doses of X-rays and neutrons. Analysis of dose-response curves. Science 176: 916–918.
Vogel, H. H., 1969, Mammary gland neoplasms after fission neutron irradiation. Nature (Lond.) 222: 1279–1281.
Withers, H. H., Brennan, J. T., and Elkind, M. M., 1970, The response of stem cells of intestinal mucosa to irradiation with 14 MeV neutrons, Brit. J. Radiol. 43: 796–801.
Wolf, S., 1954, Delay of chromosome rejoining in Vicia faba induced by irradiation, Nature (Lond.) 173: 501–502.
Selected General References Section 2
Attix, F. H., and Roesch, W. C., 1968, Radiation Dosimetry, Vol. I: Fundamentals, Academic Press, New York.
Hine, G. J., and Brownell, G. L., 1956, Radiation Dosimetry, Academic Press, New York.
ICRU, 1970, Report 16: Linear Energy Transfer, International Commission on Radiation Units and Measurements, Washington, D.C.
ICRU, 1971, Report 19: Radiation Quantities and Units, International Commission on Radiation Units and Measurements, Washington, D.C.
Rossi, H. H., 1967, Energy distribution in the absorption of radiadon, Advan. Biol. Med. Phys. 11: 27–85.
Whyte, G. N., 1959, Principles of Radiation Dosimetry, Wiley, New York.
Section 3
Elkind, M., and Whitmore, G., 1967, The Radiobiology of Cultured Mammalian Cells, Gordon and Breach, London.
Fisz, M., 1965, Probability Theory and Mathematical Statistics, Wiley, New York.
Hug, O., and Kellerer, A. M., 1966, Stochastik der Strahlenwirkung, Springer, New York.
Kellerer, A. M., and Hug, O., 1972, Theory of dose-affect relations, in: Encyclopedia of Medical Radiology, Vol. II/3, pp. 1–42, Springer, New York.
Zimmer, K. G., 1961, Studies on Quantitative Radiation Biology, Oliver and Boyd, London.,
Section 4
Kellerer, A. M., and Rossi, H. H., 1972, The theory of dual radiation action, in: Current Topics in Radiation Research, Vol. 8, pp. 85–158, North-Holland.
Lea, D. E., 1946, Actions of Radiations on Living Cells, Cambridge University Press, Cambridge.
Rossi, H. H., 1970, The effects of small doses of ionizing radiation, Phys. Med. Biol. 15: 255–262.
Savage, J. R. K., 1970, Sites of radiation induced chromosome exchanges, in: Current Topics of Radiation Research, pp. 131–194, North-Holland, Amsterdam.
Section 5
National Academy of Sciences-National Research Council, 1972, The Effects on Populations of Exposure to Low Levels of Ionizing Radiation, Washington, D.C.
U.S. Atomic energy commission, 1973, Radionuclide Carcinogenesis, CONF-720505, AEC Symposium Series 29, Washington, D.C.
United Nations, 1972, Ionizing Radiation: Levels and Effects, Vol. I, New York.
United Nations, 1972, Ionizing Radiation: Levels and Effects, Vol. II, New York.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Plenum Press, New York
About this chapter
Cite this chapter
Kellerer, A.M., Rossi, H.H. (1975). Biophysical Aspects of Radiation Carcinogenesis. In: Becker, F.F. (eds) Cancer. A Comprehensive Treatise. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4449-0_14
Download citation
DOI: https://doi.org/10.1007/978-1-4613-4449-0_14
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4451-3
Online ISBN: 978-1-4613-4449-0
eBook Packages: Springer Book Archive