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Cancer. A Comprehensive Treatise pp 3–31Cite as

Cytogenetics

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Abstract

The relationship between chromosome abnormalities and neoplasia has been the subject of investigation and speculation for many years. It was noted very early that mitotic irregularities were common in routine sections prepared from many human tumors, and these observations were extended by workers such as von Hansemann (1890) and Boveri (1914) near the turn of the century, to suggest a causal relationship between chromosome alterations and cancer. With the development of modern techniques of mammalian cytogenetics in the late 1950s, interest in chromosome studies of tumors was reawakened, and subsequently a wide variety of human and animal neoplasms were studied. This work has received additional impetus recently from the introduction of “banding” methods which permit the identification of individual chromosomes and of alterations in smaller segments of chromosomes than was possible by previous methods. These newest techniques have not yet been fully exploited, but it must also be recognized that even with the “banding” procedures there may still remain significant genetic alterations in neoplastic cells which are below the level of visual detection.

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  1. University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Peter C. Nowell

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  1. Peter C. Nowell
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  1. New York University School of Medicine, USA

    Frederick F. Becker

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© 1975 Plenum Press, New York

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Nowell, P.C. (1975). Cytogenetics. In: Becker, F.F. (eds) Cancer. A Comprehensive Treatise. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4449-0_1

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  • DOI: https://doi.org/10.1007/978-1-4613-4449-0_1

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