Abstract
Androgen binding protein (ABP) was first demonstrated in the rat epididymis (1,2). It was subsequently shown that it originates in the testes, is secreted into the lumen of the seminiferous tubule and transported to the caput epididymidis where it is partially (in the rat) or completely (in the rabbit) degraded (3,4,5). ABP is produced in the Sertoli cells (6–12) and specifically stimulated by FSH (6,7,9,10,13). Being hitherto the only well characterized specific product of the Sertoli cell, it offers itself as an index of the functional activity of the Sertoli cell, as well as a specific end point of FSH action in the testis.
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References
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Ritzen, E.M., Hagenas, L., Hansson, V., French, F.S. (1975). In Vitro Synthesis of Testicular Androgen Binding Protein (ABP): Stimulation by FSH and Androgen. In: French, F.S., Hansson, V., Ritzen, E.M., Nayfeh, S.N. (eds) Hormonal Regulation of Spermatogenesis. Current topics in Molecular Endocrinology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4440-7_25
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