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Regulation of Testosterone and Dihydrotestosterone Levels in Rete Testis Fluid. Evidence for Androgen Biosynthesis in Seminiferous Tubules in Vivo

  • Chapter
Hormonal Regulation of Spermatogenesis

Part of the book series: Current topics in Molecular Endocrinology ((CTME,volume 2))

Abstract

The lumen of the seminiferous tubules is filled with a fluid which is distinctly different in its composition compared to blood plasma and testicular lymph. Seminiferous tubular fluid is apparently secreted by the Sertoli cells (1–3). This fluid flows from the tubules through the rete testis and efferent ducts into the caput epididymidis where most of it is resorbed (1,4,5). Studies in the ram (1) and in the rat (5–8) have shown that the concentration of testosterone (T) in rete testis fluid (RTF) is much higher than peripheral blood although not as high as in testicular venous blood. These findings provide strong support to the concept that high androgen levels in the seminiferous tubules and in the proximal portion of the epididymis may plan an important role in the maintenance of spermatogenesis as well as in the survival and maturation of spermatozoa in the epididymis.

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Author information

Authors and Affiliations

  1. Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts, 01545, USA

    A. Bartke, M. E. Harris & J. K. Voglmayr

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  1. A. Bartke
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  2. M. E. Harris
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  3. J. K. Voglmayr
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Editor information

Editors and Affiliations

  1. University of Carolina, USA

    Frank S. French

  2. Rikshospitalet, Oslo, Norway

    Vidar Hansson

  3. Karolinska Sjukhuset, Stockholm, Sweden

    E. Martin Ritzen

  4. University of North Carolina, USA

    Shihadeh N. Nayfeh

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© 1975 Plenum Press, New York

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Bartke, A., Harris, M.E., Voglmayr, J.K. (1975). Regulation of Testosterone and Dihydrotestosterone Levels in Rete Testis Fluid. Evidence for Androgen Biosynthesis in Seminiferous Tubules in Vivo. In: French, F.S., Hansson, V., Ritzen, E.M., Nayfeh, S.N. (eds) Hormonal Regulation of Spermatogenesis. Current topics in Molecular Endocrinology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4440-7_14

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  • DOI: https://doi.org/10.1007/978-1-4613-4440-7_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4442-1

  • Online ISBN: 978-1-4613-4440-7

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