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Some Factors Affecting Testosterone, Dihydrotestosterone, 5α-Andro­stan-3α,17β-Diol and 5α-Androstan-3β,17β-Diol Secretion by in Vitro Perfused Rabbit Testes

  • Larry L. Ewing
Part of the Current topics in Molecular Endocrinology book series (CTME, volume 2)

Abstract

Dihydrotestosterone* and 5α-androstan-3α,17β-diol are present in the peripheral circulation of several vertebrate species (1–11). Although considerable quantities of these 5α-reduced androgens are derived via the peripheral conversion of blood borne precursors (5,12,13) it is now clear that significant amounts of 5α-reduced androgens originate from the gonads of two species, namely, dogs (6,14) and rabbits (15,16). The most likely explanation for gonadal derivation of these androgens is that testicular and epidi­dymal function are testosterone dependent (17,18) and that testosterone probably exerts its regulatory effects only after conversion to DHT (19,20) which subsequently is metabolized to androstanediols (3α-androstanediol and 3β-androstanediol) in the male gonad. Thus, testosterone secretion might represent a balance between intra-testicular biosynthesis on one hand and intratesticular metabolism on the other. In fact, such a scheme has been proposed to explain the transient changes in net testosterone biosynthesis in maturing guinea pig (21) and rat (22–28) testis. Significant metabolism of a steroidal hormone prior to its secretion from the biosynthetic source is not without precedent since Kitay and co-workers (29–32) showed that corticosterone secretion by the rat adrenal depends not only upon the rate of corticosterone synthesis but also upon its conversion to 5α-reduced metabolites.

Keywords

Germ Cell Seminiferous Tubule Artificial Medium Cyproterone Acetate Spermatic Vein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Larry L. Ewing
    • 1
  1. 1.Division of Reproductive Biology, Department of Population DynamicsJohns Hopkins School of HygieneBaltimoreUSA

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